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Literature summary for 1.1.1.28 extracted from

  • Kochhar, S.; Lamzin, V.S.; Razeto, A.; Delley, M.; Hottinger, H.; Germond, J.E.
    Roles of His205, His296, His303 and Asp259 in catalysis by NAD+-specific D-lactate dehydrogenase (2000), Eur. J. Biochem., 267, 1633-1639.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D259N 56fold reduction in kcat, 5fold lowering of Km, shifting of the enzymatic activity profile towards the acidic range by two units Lactobacillus delbrueckii subsp. bulgaricus
H205K 125-fold reduction in Kcat Lactobacillus delbrueckii subsp. bulgaricus
H296K no significant change Lactobacillus delbrueckii subsp. bulgaricus
H303K Km for pyruvate increased fourfold Lactobacillus delbrueckii subsp. bulgaricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(R)-lactate + NAD+ Lactobacillus delbrueckii subsp. bulgaricus
-
pyruvate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Lactobacillus delbrueckii subsp. bulgaricus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-lactate + NAD+
-
Lactobacillus delbrueckii subsp. bulgaricus pyruvate + NADH
-
?