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Literature summary for 1.1.1.27 extracted from

  • Gorelikov, P.L.; Savelev, S.V.
    Lactate dehydrogenase isoenzymes in sympathetic neurons and satellite gliocytes in normal conditions and in blockade of nicotinic cholinoreceptors (2008), Neurosci. Behav. Physiol., 38, 817-820.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information blockade of nicotinic cholinoreceptors significantly decreases total LDH activity and H- and M-isoform activities in neurons. LDH activity decreases by 41.5% and 71% in conditions of partial and complete blockade, respectively. Decreases in H-isoform activity are by 25% in partial blockade and 42% in complete blockade and decreases in M-isoform activity are by 35% and 62%. In partial and complete blockade, the activity of LDH and its H- and M-isoforms decrease significantly in proportion to the number of blocked nicotinic cholinoreceptors. In satellite gliocytes, increases in the extent of blockade are associated with decreases in the activity only of the M-isoform (by 43% in partial blockade and 55.5% in complete blockade), while the activity of the H-isoform does not change. In partial blockade, the LDH isoenzyme profile of satellite gliocytes shifts towards the neuronal isoform, while in complete blockade there is no difference from the LDH isoenzyme profile of intact neurons Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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Source Tissue

Source Tissue Comment Organism Textmining
additional information in satellite gliocytes, activities of both H- and M-isoforms of LDH are high, dominance of M-isoform activity Oryctolagus cuniculus
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neuron activities of both H- and M-isoforms of LDH are high but neurons show a dominance of H-isoform activity Oryctolagus cuniculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the formation of lactate in satellite gliocytes is induced by nicotinic cholinergic synapses directly involved in neuron-glial interactions and in controlling the activity of the LDH enzyme system in sympathetic neurons Oryctolagus cuniculus ?
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Synonyms

Synonyms Comment Organism
lactate dehydrogenase
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Oryctolagus cuniculus
LDH
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Oryctolagus cuniculus