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BRENDA support

Literature summary for 1.1.1.27 extracted from

  • Starnes, J.
    Effect of storage conditions on lactate dehydrogenase released from perfused hearts (2008), Int. J. Cardiol., 127, 114-116.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information hearts perfused with Krebs-Henseleit buffer, subjected to 30 min of global ischemia followed by normoxic reperfusion, which causes tissue damage and elevate LDH release Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information short-term storage in Krebs-Henseleit buffer for 24 h at 4°C does not affect LDH activity, but a 42% decline occurs at 23°C. After 48 h, activity declines 11% at 4°C and 98% at 23°C. Frozen storage results in a 40% loss at -80°C and a 79% loss at -20°C Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
female Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Storage Stability

Storage Stability Organism
4°C, Krebs-Henseleit buffer, 24 h Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
Rattus norvegicus lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
lactate dehydrogenase
-
Rattus norvegicus
LDH
-
Rattus norvegicus