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Literature summary for 1.1.1.27 extracted from

  • Tokuhiro, K.; Ishida, N.; Nagamori, E.; Saitoh, S.; Onishi, T.; Kondo, A.; Takahashi, H.
    Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene (2009), Appl. Microbiol. Biotechnol., 82, 883-890.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae replacing disrupted pyruvate decarboxylase 1 and alcohol dehydrogenase 1 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.1
-
single pyruvate decarboxylase 1 mutant strain T157 Bos taurus
11.5
-
pyruvate decarboxylase 1/alcohol dehydrogenase 1 mutant strain AF297C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH lactate yield is increased in the pyruvate decarboxylase 1/alcohol dehydrogenase 1 double mutant compared with that in the single pyruvate decarboxylase 1 mutant Bos taurus L-lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
L-LDH
-
Bos taurus