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Literature summary for 1.1.1.27 extracted from

  • Kade, I.J.; Paixao, M.W.; Rodrigues, O.E.; Ibukun, E.O.; Braga, A.L.; Zeni, G.; Nogueira, C.W.; Rocha, J.B.
    Studies on the antioxidant effect and interaction of diphenyl diselenide and dicholesteroyl diselenide with hepatic delta-aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase (2009), Toxicol. In Vitro, 23, 14-20.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dicholesteroyl diselenide inhibition of different isoforms of lactate dehydrogenase by dicholesteroyl diselenide possibly involves the modification of the thiol groups at the NAD+ binding site of the enzyme. Exerts profound concentration dependent inhibitory effect on the activity of renal LDH. Inhibitory effect on hepatic LDH is markedly pronounced at 2, 4, 8 and 10 microM. Strongly inhibits cardiac LDH activity when NAD+ is omitted from the pre-incubating medium than when lactate is absent from the pre-incubating medium, significantly inhibits the enzyme activity at 1, 2, 4, and 8 microM Rattus norvegicus
diphenyl diselenide inhibition of different isoforms of lactate dehydrogenase by diphenyl diselenide possibly involves the modification of the thiol groups at the NAD+ binding site of the enzyme. Inhibitory effect on hepatic LDH is markedly different at 10 microM. Markedly inhibits cardiac LDH activity at 8 and 10 microM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male adult Wistar rats
-

Purification (Commentary)

Purification (Comment) Organism
partially purified renal LDH Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
Rattus norvegicus L-lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
lactate dehydrogenase
-
Rattus norvegicus
LDH
-
Rattus norvegicus