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Literature summary for 1.1.1.27 extracted from

  • Richardson, A.R.; Libby, S.J.; Fang, F.C.
    A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity (2008), Science, 319, 1672-1676.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is induced by nitric aoxide Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by nitric oxide Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + NADH + H+ Staphylococcus aureus the nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity, L-lactate production allows Staphylococcus aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence, regulation, overview (S)-lactate + NAD+
-
r

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
gene ldh1
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information metabolic adaptation of Staphylococcus aureus to nitrosative stress, overview Staphylococcus aureus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
Staphylococcus aureus (S)-lactate + NAD+
-
r
pyruvate + NADH + H+ the nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity, L-lactate production allows Staphylococcus aureus to maintain redox homeostasis during nitrosative stress and is essential for virulence, regulation, overview Staphylococcus aureus (S)-lactate + NAD+
-
r

Synonyms

Synonyms Comment Organism
lactate dehydrogenase
-
Staphylococcus aureus
LDH
-
Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Staphylococcus aureus
NADH
-
Staphylococcus aureus