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Literature summary for 1.1.1.27 extracted from

  • Koiri, R.K.; Trigun, S.K.; Dubey, S.K.; Singh, S.; Mishra, L.
    Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase (2008), Biometals, 21, 117-126.
    View publication on PubMed

Application

Application Comment Organism
drug development LDH is critically implicated in tumor growth and therefore considered to be an important target protein for antitumor metal complexes Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Cu[Ac]2[2,2'-bipyridine] analysis of interaction with the LDH isozymes and their modulation, significantly inhibits LDH in liver, kidney, heart, spleen, brain and skeletal muscle tissues, overview Mus musculus
Zn[Ac]2[2,2'-bipyridine] analysis of interaction with the LDH isozymes and their modulation, significantly inhibits LDH in liver, kidney, and heart, but not in spleen, brain and skeletal muscle tissues, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion LDH-A Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-lactate + NAD+ Mus musculus
-
pyruvate + NADH + H+
-
r
(S)-lactate + NAD+ Mus musculus AKR
-
pyruvate + NADH + H+
-
r
additional information Mus musculus LDH is critically implicated in tumor growth ?
-
?
additional information Mus musculus AKR LDH is critically implicated in tumor growth ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus AKR
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell differential expressions of LDH isozymes in different types of tumors Mus musculus
-
heart H-type isozyme Mus musculus
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
muscle M-type isozyme Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + NAD+
-
Mus musculus pyruvate + NADH + H+
-
r
(S)-lactate + NAD+
-
Mus musculus AKR pyruvate + NADH + H+
-
r
additional information LDH is critically implicated in tumor growth Mus musculus ?
-
?
additional information LDH is critically implicated in tumor growth Mus musculus AKR ?
-
?

Synonyms

Synonyms Comment Organism
LDH
-
Mus musculus
LDH-A
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus
NADH
-
Mus musculus