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Literature summary for 1.1.1.27 extracted from

  • Bork, S.; Okamura, M.; Boonchit, S.; Hirata, H.; Yokoyama, N.; Igarashi, I.
    Identification of Babesia bovis L-lactate dehydrogenase as a potential chemotherapeutical target against bovine babesiosis (2004), Mol. Biochem. Parasitol., 136, 165-172.
    View publication on PubMed

Application

Application Comment Organism
medicine suitable drug target for design of novel babesial chemotherapeutics Babesia bovis

Cloned(Commentary)

Cloned (Comment) Organism
-
Babesia bovis

Inhibitors

Inhibitors Comment Organism Structure
gossypol competitive with NADH Babesia bovis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0081
-
NADH
-
Babesia bovis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm of intra- and extraerythrocytic parasites Babesia bovis 5737
-
membrane of infected erythrocytes Babesia bovis 16020
-

Organism

Organism UniProt Comment Textmining
Babesia bovis Q7Z0X7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
Babesia bovis (S)-lactate + NAD+
-
?

Synonyms

Synonyms Comment Organism
BbLDH
-
Babesia bovis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
216.7
-
NADH
-
Babesia bovis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Babesia bovis