Application | Comment | Organism |
---|---|---|
medicine | potential drug target for new antimalarials | Plasmodium malariae |
medicine | potential drug target for new antimalarials | Plasmodium ovale |
medicine | potential drug target for new antimalarials | Plasmodium vivax |
medicine | potential drug target for new antimalarials | Plasmodium falciparum |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Plasmodium malariae |
expression in Escherichia coli | Plasmodium ovale |
expression in Escherichia coli | Plasmodium vivax |
expression in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gossylic nitrile 1,1'-diacetate | - |
Plasmodium falciparum | |
gossylic nitrile 1,1'-diacetate | - |
Plasmodium malariae | |
gossylic nitrile 1,1'-diacetate | - |
Plasmodium ovale | |
gossylic nitrile 1,1'-diacetate | - |
Plasmodium vivax | |
gossypol | - |
Plasmodium falciparum | |
gossypol | - |
Plasmodium malariae | |
gossypol | - |
Plasmodium ovale | |
gossypol | - |
Plasmodium vivax | |
gossypol lactone | - |
Plasmodium falciparum | |
gossypol lactone | - |
Plasmodium malariae | |
gossypol lactone | - |
Plasmodium ovale | |
gossypol lactone | - |
Plasmodium vivax |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
NADH | pH 7.5, 25°C | Plasmodium vivax | |
0.007 | - |
NADH | pH 7.5, 25°C | Plasmodium falciparum | |
0.009 | - |
NADH | pH 7.5, 25°C | Plasmodium malariae | |
0.014 | - |
NADH | pH 7.5, 25°C | Plasmodium ovale | |
0.017 | - |
pyruvate | pH 7.5, 25°C | Plasmodium vivax | |
0.03 | - |
pyruvate | pH 7.5, 25°C | Plasmodium falciparum | |
0.071 | - |
pyruvate | pH 7.5, 25°C | Plasmodium ovale | |
0.086 | - |
NAD+ | pH 9.2, 25°C | Plasmodium falciparum | |
0.123 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium falciparum | |
0.14 | - |
pyruvate | pH 7.5, 25°C | Plasmodium malariae | |
0.143 | - |
NAD+ | pH 9.2, 25°C | Plasmodium malariae | |
0.155 | - |
NAD+ | pH 9.2, 25°C | Plasmodium vivax | |
0.168 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium malariae | |
0.182 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium vivax | |
0.311 | - |
NAD+ | pH 9.2, 25°C | Plasmodium ovale | |
0.408 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium ovale | |
10.2 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium vivax | |
11.3 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium malariae | |
12 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium falciparum | |
93 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium ovale |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q27743 | - |
- |
Plasmodium malariae | - |
- |
- |
Plasmodium ovale | - |
- |
- |
Plasmodium vivax | Q6JH30 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium malariae |
- |
Plasmodium ovale |
- |
Plasmodium vivax |
- |
Plasmodium falciparum |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
215 | - |
reduction of pyruvate | Plasmodium ovale |
216 | - |
reduction of pyruvate | Plasmodium malariae |
253 | - |
reduction of pyruvate | Plasmodium falciparum |
450 | - |
reduction of pyruvate | Plasmodium vivax |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + 3-acetylpyridine adenine dinucleotide | - |
Plasmodium malariae | pyruvate + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
(S)-lactate + 3-acetylpyridine adenine dinucleotide | - |
Plasmodium ovale | pyruvate + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
(S)-lactate + 3-acetylpyridine adenine dinucleotide | - |
Plasmodium vivax | pyruvate + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
(S)-lactate + 3-acetylpyridine adenine dinucleotide | - |
Plasmodium falciparum | pyruvate + reduced 3-acetylpyridine adenine dinucleotide | - |
? | |
pyruvate + NADH + H+ | - |
Plasmodium malariae | (S)-lactate + NAD+ | - |
r | |
pyruvate + NADH + H+ | - |
Plasmodium ovale | (S)-lactate + NAD+ | - |
r | |
pyruvate + NADH + H+ | - |
Plasmodium vivax | (S)-lactate + NAD+ | - |
r | |
pyruvate + NADH + H+ | - |
Plasmodium falciparum | (S)-lactate + NAD+ | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
12.33 | - |
NAD+ | pH 9.2, 25°C | Plasmodium vivax | |
12.33 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium vivax | |
25 | - |
NAD+ | pH 9.2, 25°C | Plasmodium ovale | |
25 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium ovale | |
38.33 | - |
NAD+ | pH 9.2, 25°C | Plasmodium malariae | |
38.33 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium malariae | |
65 | - |
NAD+ | pH 9.2, 25°C | Plasmodium falciparum | |
65 | - |
(S)-lactate | pH 9.2, 25°C | Plasmodium falciparum | |
125 | - |
NADH | pH 7.5, 25°C | Plasmodium malariae | |
125 | - |
pyruvate | pH 7.5, 25°C | Plasmodium malariae | |
126.7 | - |
NADH | pH 7.5, 25°C | Plasmodium vivax | |
126.7 | - |
pyruvate | pH 7.5, 25°C | Plasmodium vivax | |
148.3 | - |
NADH | pH 7.5, 25°C | Plasmodium falciparum | |
148.3 | - |
pyruvate | pH 7.5, 25°C | Plasmodium falciparum | |
153.3 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium ovale | |
233.3 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium malariae | |
250 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium falciparum | |
266.7 | - |
NADH | pH 7.5, 25°C | Plasmodium ovale | |
266.7 | - |
pyruvate | pH 7.5, 25°C | Plasmodium ovale | |
333.3 | - |
3-acetylpyridine adenine dinucleotide | pH 9.2, 25°C | Plasmodium vivax |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Plasmodium malariae | |
NAD+ | - |
Plasmodium ovale | |
NAD+ | - |
Plasmodium vivax | |
NAD+ | - |
Plasmodium falciparum | |
NADH | - |
Plasmodium malariae | |
NADH | - |
Plasmodium ovale | |
NADH | - |
Plasmodium vivax | |
NADH | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00007 | - |
gossypol lactone | pH 7.5, 25°C | Plasmodium vivax | |
0.00024 | - |
gossylic nitrile 1,1'-diacetate | pH 7.5, 25°C | Plasmodium vivax | |
0.0004 | - |
gossypol lactone | pH 7.5, 25°C | Plasmodium falciparum | |
0.0005 | - |
gossypol lactone | pH 7.5, 25°C | Plasmodium ovale | |
0.0007 | - |
gossypol | pH 7.5, 25°C | Plasmodium falciparum | |
0.0007 | - |
gossylic nitrile 1,1'-diacetate | pH 7.5, 25°C | Plasmodium ovale | |
0.0007 | - |
gossylic nitrile 1,1'-diacetate | pH 7.5, 25°C | Plasmodium falciparum | |
0.0014 | - |
gossypol | pH 7.5, 25°C | Plasmodium vivax | |
0.0015 | - |
gossypol lactone | pH 7.5, 25°C | Plasmodium malariae | |
0.0018 | - |
gossylic nitrile 1,1'-diacetate | pH 7.5, 25°C | Plasmodium malariae | |
0.0019 | - |
gossypol | pH 7.5, 25°C | Plasmodium ovale | |
0.0126 | - |
gossypol | pH 7.5, 25°C | Plasmodium malariae |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Plasmodium vivax | - |
- |
6 |
Plasmodium falciparum | - |
- |
6.5 |
Plasmodium malariae | - |
- |
6.9 |
Plasmodium ovale | - |
- |
8 |