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Literature summary for 1.1.1.27 extracted from

  • Brown, W.M.; Yowell, C.A.; Hoard, A.; vander Jagt, T.A.; Hunsaker, L.A.; Deck, L.M.; Royer, R.E.; Piper, R.C.; Dame, J.B.; Makler, M.T.; vander Jagt, D.L.
    Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human Malarial parasites (2004), Biochemistry, 43, 6219-6229.
    View publication on PubMed

Application

Application Comment Organism
medicine potential drug target for new antimalarials Plasmodium malariae
medicine potential drug target for new antimalarials Plasmodium ovale
medicine potential drug target for new antimalarials Plasmodium vivax
medicine potential drug target for new antimalarials Plasmodium falciparum

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Plasmodium malariae
expression in Escherichia coli Plasmodium ovale
expression in Escherichia coli Plasmodium vivax
expression in Escherichia coli Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
gossylic nitrile 1,1'-diacetate
-
Plasmodium falciparum
gossylic nitrile 1,1'-diacetate
-
Plasmodium malariae
gossylic nitrile 1,1'-diacetate
-
Plasmodium ovale
gossylic nitrile 1,1'-diacetate
-
Plasmodium vivax
gossypol
-
Plasmodium falciparum
gossypol
-
Plasmodium malariae
gossypol
-
Plasmodium ovale
gossypol
-
Plasmodium vivax
gossypol lactone
-
Plasmodium falciparum
gossypol lactone
-
Plasmodium malariae
gossypol lactone
-
Plasmodium ovale
gossypol lactone
-
Plasmodium vivax

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
NADH pH 7.5, 25°C Plasmodium vivax
0.007
-
NADH pH 7.5, 25°C Plasmodium falciparum
0.009
-
NADH pH 7.5, 25°C Plasmodium malariae
0.014
-
NADH pH 7.5, 25°C Plasmodium ovale
0.017
-
pyruvate pH 7.5, 25°C Plasmodium vivax
0.03
-
pyruvate pH 7.5, 25°C Plasmodium falciparum
0.071
-
pyruvate pH 7.5, 25°C Plasmodium ovale
0.086
-
NAD+ pH 9.2, 25°C Plasmodium falciparum
0.123
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium falciparum
0.14
-
pyruvate pH 7.5, 25°C Plasmodium malariae
0.143
-
NAD+ pH 9.2, 25°C Plasmodium malariae
0.155
-
NAD+ pH 9.2, 25°C Plasmodium vivax
0.168
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium malariae
0.182
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium vivax
0.311
-
NAD+ pH 9.2, 25°C Plasmodium ovale
0.408
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium ovale
10.2
-
(S)-lactate pH 9.2, 25°C Plasmodium vivax
11.3
-
(S)-lactate pH 9.2, 25°C Plasmodium malariae
12
-
(S)-lactate pH 9.2, 25°C Plasmodium falciparum
93
-
(S)-lactate pH 9.2, 25°C Plasmodium ovale

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q27743
-
-
Plasmodium malariae
-
-
-
Plasmodium ovale
-
-
-
Plasmodium vivax Q6JH30
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Plasmodium malariae
-
Plasmodium ovale
-
Plasmodium vivax
-
Plasmodium falciparum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
215
-
reduction of pyruvate Plasmodium ovale
216
-
reduction of pyruvate Plasmodium malariae
253
-
reduction of pyruvate Plasmodium falciparum
450
-
reduction of pyruvate Plasmodium vivax

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + 3-acetylpyridine adenine dinucleotide
-
Plasmodium malariae pyruvate + reduced 3-acetylpyridine adenine dinucleotide
-
?
(S)-lactate + 3-acetylpyridine adenine dinucleotide
-
Plasmodium ovale pyruvate + reduced 3-acetylpyridine adenine dinucleotide
-
?
(S)-lactate + 3-acetylpyridine adenine dinucleotide
-
Plasmodium vivax pyruvate + reduced 3-acetylpyridine adenine dinucleotide
-
?
(S)-lactate + 3-acetylpyridine adenine dinucleotide
-
Plasmodium falciparum pyruvate + reduced 3-acetylpyridine adenine dinucleotide
-
?
pyruvate + NADH + H+
-
Plasmodium malariae (S)-lactate + NAD+
-
r
pyruvate + NADH + H+
-
Plasmodium ovale (S)-lactate + NAD+
-
r
pyruvate + NADH + H+
-
Plasmodium vivax (S)-lactate + NAD+
-
r
pyruvate + NADH + H+
-
Plasmodium falciparum (S)-lactate + NAD+
-
r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
12.33
-
NAD+ pH 9.2, 25°C Plasmodium vivax
12.33
-
(S)-lactate pH 9.2, 25°C Plasmodium vivax
25
-
NAD+ pH 9.2, 25°C Plasmodium ovale
25
-
(S)-lactate pH 9.2, 25°C Plasmodium ovale
38.33
-
NAD+ pH 9.2, 25°C Plasmodium malariae
38.33
-
(S)-lactate pH 9.2, 25°C Plasmodium malariae
65
-
NAD+ pH 9.2, 25°C Plasmodium falciparum
65
-
(S)-lactate pH 9.2, 25°C Plasmodium falciparum
125
-
NADH pH 7.5, 25°C Plasmodium malariae
125
-
pyruvate pH 7.5, 25°C Plasmodium malariae
126.7
-
NADH pH 7.5, 25°C Plasmodium vivax
126.7
-
pyruvate pH 7.5, 25°C Plasmodium vivax
148.3
-
NADH pH 7.5, 25°C Plasmodium falciparum
148.3
-
pyruvate pH 7.5, 25°C Plasmodium falciparum
153.3
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium ovale
233.3
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium malariae
250
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium falciparum
266.7
-
NADH pH 7.5, 25°C Plasmodium ovale
266.7
-
pyruvate pH 7.5, 25°C Plasmodium ovale
333.3
-
3-acetylpyridine adenine dinucleotide pH 9.2, 25°C Plasmodium vivax

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Plasmodium malariae
NAD+
-
Plasmodium ovale
NAD+
-
Plasmodium vivax
NAD+
-
Plasmodium falciparum
NADH
-
Plasmodium malariae
NADH
-
Plasmodium ovale
NADH
-
Plasmodium vivax
NADH
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00007
-
gossypol lactone pH 7.5, 25°C Plasmodium vivax
0.00024
-
gossylic nitrile 1,1'-diacetate pH 7.5, 25°C Plasmodium vivax
0.0004
-
gossypol lactone pH 7.5, 25°C Plasmodium falciparum
0.0005
-
gossypol lactone pH 7.5, 25°C Plasmodium ovale
0.0007
-
gossypol pH 7.5, 25°C Plasmodium falciparum
0.0007
-
gossylic nitrile 1,1'-diacetate pH 7.5, 25°C Plasmodium ovale
0.0007
-
gossylic nitrile 1,1'-diacetate pH 7.5, 25°C Plasmodium falciparum
0.0014
-
gossypol pH 7.5, 25°C Plasmodium vivax
0.0015
-
gossypol lactone pH 7.5, 25°C Plasmodium malariae
0.0018
-
gossylic nitrile 1,1'-diacetate pH 7.5, 25°C Plasmodium malariae
0.0019
-
gossypol pH 7.5, 25°C Plasmodium ovale
0.0126
-
gossypol pH 7.5, 25°C Plasmodium malariae

pI Value

Organism Comment pI Value Maximum pI Value
Plasmodium vivax
-
-
6
Plasmodium falciparum
-
-
6.5
Plasmodium malariae
-
-
6.9
Plasmodium ovale
-
-
8