Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-Aminopyridine adenine dinucleotide | competitive versus NAD+ and noncompetitive versus L-lactate | Anas platyrhynchos | |
Alpha-NAD+ | noncompetitive inhibitor versus beta-NAD+ | Anas platyrhynchos | |
D-lactate | dead-end inhibitor, competitive inhibitor versus L-lactate | Anas platyrhynchos | |
L-lactate | substrate inhibition is uncompetitive | Anas platyrhynchos | |
nicotinic acid adenine dinucleotide | competitive versus NAD+ and noncompetitive versus L-lactate | Anas platyrhynchos | |
oxamate | dead-end inhibitor, competitive inhibitor versus pyruvate | Anas platyrhynchos | |
pyruvate | substrate inhibition is uncompetitive | Anas platyrhynchos | |
Tartronate | dead-end inhibitor, competitive inhibitor versus L-lactate | Anas platyrhynchos | |
Thionicotinamide adenine dinucleotide | competitive versus NAD+ and noncompetitive versus L-lactate | Anas platyrhynchos |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Anas platyrhynchos | - |
epsilon-crystallin | - |
Gallus gallus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(S)-lactate + NAD+ = pyruvate + NADH + H+ | mechanism | Anas platyrhynchos |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Gallus gallus | - |
muscle | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + 3-acetylpyridine adenine dinucleotide | - |
Gallus gallus | pyruvate + reduced 3-acetylpyridine adenine dinucleotide | - |
r | |
(S)-lactate + 3-acetylpyridine adenine dinucleotide | - |
Anas platyrhynchos | pyruvate + reduced 3-acetylpyridine adenine dinucleotide | - |
r | |
(S)-lactate + epsilon-NAD+ | - |
Anas platyrhynchos | pyruvate + epsilon-NADH + H+ | - |
r | |
(S)-lactate + nicotinamide hypoxanthine dinucleotide | - |
Gallus gallus | pyruvate + reduced nicotinamide hypoxanthine dinucleotide | - |
r | |
(S)-lactate + nicotinamide hypoxanthine dinucleotide | - |
Anas platyrhynchos | pyruvate + reduced nicotinamide hypoxanthine dinucleotide | - |
r | |
3-fluoropyruvate + NADH | - |
Gallus gallus | ? | - |
? | |
3-fluoropyruvate + NADH | - |
Anas platyrhynchos | ? | - |
? | |
bromopyruvate + NADH | - |
Anas platyrhynchos | 3-bromo-2-hydroxypropanoate + NAD+ | - |
? | |
pyruvate + NADH + H+ | - |
Gallus gallus | (S)-lactate + NAD+ | - |
? | |
pyruvate + NADH + H+ | - |
Anas platyrhynchos | (S)-lactate + NAD+ | - |
r | |
pyruvate ethyl ester + NADH | - |
Anas platyrhynchos | 2-hydroxypropanoate ethyl ester | - |
? | |
pyruvate methyl ester + NADH | - |
Anas platyrhynchos | 2-hydroxypropanoate methyl ester | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
epsilon-NAD+ | - |
Anas platyrhynchos | |
1.1 | - |
nicotinamide hypoxanthine dinucleotide | - |
Anas platyrhynchos | |
1.1 | - |
nicotinamide hypoxanthine dinucleotide | enzyme from muscle | Gallus gallus | |
1.4 | - |
3-acetylpyridine adenine dinucleotide | - |
Anas platyrhynchos | |
3.3 | - |
NAD+ | enzyme from muscle | Gallus gallus | |
5.3 | - |
epsilon-NAD+ | - |
Anas platyrhynchos | |
5.5 | - |
nicotinamide hypoxanthine dinucleotide | - |
Anas platyrhynchos | |
6.2 | - |
epsilon-NAD+ | enzyme from heart | Anas platyrhynchos | |
6.9 | - |
NAD+ | - |
Anas platyrhynchos | |
16 | - |
3-acetylpyridine adenine dinucleotide | enzyme form heart and muscle | Gallus gallus | |
18.8 | - |
nicotinamide hypoxanthine dinucleotide | enzyme from heart | Anas platyrhynchos | |
60 | - |
NAD+ | enzyme from heart | Gallus gallus | |
98 | - |
Fluoropyruvate | - |
Gallus gallus | |
176 | - |
pyruvate ethyl ester | - |
Anas platyrhynchos | |
204 | - |
pyruvate | - |
Anas platyrhynchos | |
227 | - |
pyruvate methyl ester | - |
Anas platyrhynchos | |
269 | - |
Bromopyruvate | - |
Anas platyrhynchos |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
3-acetylpyridine adenine dinucleotide | alternative coenzyme | Anas platyrhynchos | |
NADH | coenzyme | Gallus gallus | |
nicotinamide hypoxanthine dinucleotide | alternative coenzyme | Anas platyrhynchos | |
thio-NAD+ | alternative coenzyme | Anas platyrhynchos |