Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hg2+ | - |
Molinema dessetae | |
iodoacetate | - |
Molinema dessetae | |
oxalate | noncompetitive with pyruvate, competitive with lactate | Molinema dessetae | |
oxamate | competitive with pyruvate, noncompetitive with lactate | Molinema dessetae | |
p-chloromercuribenzoate | - |
Molinema dessetae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
NAD+ | - |
Molinema dessetae | |
0.25 | - |
NADH | - |
Molinema dessetae | |
0.34 | - |
pyruvate | - |
Molinema dessetae | |
2.5 | - |
(S)-lactate | - |
Molinema dessetae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
2 * 58000, isoenzyme LDH1 and LDH2, SDS-PAGE | Molinema dessetae |
113000 | - |
gel filtration | Molinema dessetae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Molinema dessetae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
two major isoenzymes LDH1 and LDH2 | Molinema dessetae |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
80.27 | - |
- |
Molinema dessetae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-lactate + NAD+ | pyruvate reduction is the favored reaction | Molinema dessetae | pyruvate + NADH + H+ | - |
r | |
pyruvate + NADH + H+ | pyruvate reduction is the favored reaction | Molinema dessetae | (S)-lactate + NAD+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 58000, isoenzyme LDH1 and LDH2, SDS-PAGE | Molinema dessetae |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
15 min, 2% loss of activity | Molinema dessetae |
55 | - |
stable below | Molinema dessetae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
reduction of pyruvate | Molinema dessetae |
8.6 | - |
oxidation of lactate | Molinema dessetae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | pH 6.0: 85% of maximal activity, pH 8.0: 45% of maximal activity, reduction of pyruvate | Molinema dessetae |
8 | 9.6 | pH 8.0: 60% of maximal activity, pH 9.6: 45% of maximal activity, oxidation of lactate | Molinema dessetae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | coenzyme | Molinema dessetae | |
NADH | coenzyme | Molinema dessetae |