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Literature summary for 1.1.1.27 extracted from

  • Mou, L.; Mulvena, D.P.; Jonas, H.A.; Jago, G.R.
    Purification and properties of nicotinamide adenine dinucleotide-dependent D- and L-lactate dehydrogenases in a group N streptococcus (1972), J. Bacteriol., 111, 392-396.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
-
-
-
Lactococcus lactis 760
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Lactococcus lactis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Lactococcus lactis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + NAD+
-
Lactococcus lactis pyruvate + NADH + H+
-
r
(S)-lactate + NAD+
-
Lactococcus lactis 760 pyruvate + NADH + H+
-
r
pyruvate + NADH + H+
-
Lactococcus lactis (S)-lactate + NAD+
-
r
pyruvate + NADH + H+
-
Lactococcus lactis 760 (S)-lactate + NAD+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 7 reduction of pyruvate, in presence of fructose 1,6-diphosphate Lactococcus lactis
8
-
reduction of pyruvate, in absence of fructose 1,6-diphosphate Lactococcus lactis

pH Stability

pH Stability pH Stability Maximum Comment Organism
5 7.5 rapid loss of activity below pH 5.0 and above pH 7.5 Lactococcus lactis

Cofactor

Cofactor Comment Organism Structure
NAD+ coenzyme Lactococcus lactis
NADH coenzyme Lactococcus lactis