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Literature summary for 1.1.1.261 extracted from

  • Koga, Y.; Morii, H.
    Biosynthesis of ether-type polar lipids in archaea and evolutionary considerations (2007), Microbiol. Mol. Biol. Rev., 71, 97-120.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
phylogenetic analysis Methanosarcina barkeri
phylogenetic analysis Pyrococcus sp.
phylogenetic analysis Methanothermobacter thermautotrophicus
phylogenetic analysis Pyrococcus furiosus
phylogenetic analysis Halobacterium salinarum
phylogenetic analysis Thermoplasma acidophilum
phylogenetic analysis Aeropyrum pernix
phylogenetic analysis Sulfurisphaera tokodaii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic analysis Aeropyrum pernix

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required Methanosarcina barkeri
Zn2+ required Pyrococcus sp.
Zn2+ required Methanothermobacter thermautotrophicus
Zn2+ required Pyrococcus furiosus
Zn2+ required Halobacterium salinarum
Zn2+ required Thermoplasma acidophilum
Zn2+ required Aeropyrum pernix
Zn2+ required Sulfurisphaera tokodaii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydroxyacetonephosphate + NAD(P)H Sulfurisphaera tokodaii metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Methanosarcina barkeri the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Pyrococcus sp. the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Pyrococcus furiosus the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Halobacterium salinarum the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Thermoplasma acidophilum the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Aeropyrum pernix the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Methanothermobacter thermautotrophicus the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol-1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Pyrococcus sp. KS8-1 the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H Thermoplasma acidophilum HO-62 the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview glycerol 1-phosphate + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Aeropyrum pernix
-
-
-
Halobacterium salinarum
-
-
-
Methanosarcina barkeri
-
-
-
Methanothermobacter thermautotrophicus
-
-
-
Pyrococcus furiosus
-
-
-
Pyrococcus sp.
-
-
-
Pyrococcus sp. KS8-1
-
-
-
Sulfurisphaera tokodaii
-
-
-
Thermoplasma acidophilum
-
-
-
Thermoplasma acidophilum HO-62
-
-
-

Reaction

Reaction Comment Organism Reaction ID
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Methanosarcina barkeri
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Pyrococcus sp.
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Methanothermobacter thermautotrophicus
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Pyrococcus furiosus
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Halobacterium salinarum
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Thermoplasma acidophilum
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Aeropyrum pernix
sn-glycerol 1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+ reaction mechanism with transfer of pro-R hydrogen of NAD(P)H and a chiral product Sulfurisphaera tokodaii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydroxyacetonephosphate + NAD(P)H metabolic pathway possibilities, overview Sulfurisphaera tokodaii glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Methanosarcina barkeri glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Pyrococcus sp. glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Pyrococcus furiosus glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Halobacterium salinarum glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Thermoplasma acidophilum glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Aeropyrum pernix glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Methanosarcina barkeri glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Pyrococcus sp. glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Pyrococcus furiosus glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Halobacterium salinarum glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Thermoplasma acidophilum glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Sulfurisphaera tokodaii glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, the reduction reaction is preferred, overview Aeropyrum pernix glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Pyrococcus sp. KS8-1 glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Pyrococcus sp. KS8-1 glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Thermoplasma acidophilum HO-62 glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Thermoplasma acidophilum HO-62 glycerol 1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H the enzyme is involved in formation of the enantiomeric glycerophosphate backbone structure of archaeal phospholipids, metabolic pathway possibilities, overview Methanothermobacter thermautotrophicus glycerol-1-phosphate + NAD(P)+
-
r
dihydroxyacetonephosphate + NAD(P)H active site structure and molecular mechanism, overview Methanothermobacter thermautotrophicus glycerol-1-phosphate + NAD(P)+
-
r

Synonyms

Synonyms Comment Organism
G-1-P dehydrogenase
-
Methanosarcina barkeri
G-1-P dehydrogenase
-
Pyrococcus sp.
G-1-P dehydrogenase
-
Methanothermobacter thermautotrophicus
G-1-P dehydrogenase
-
Pyrococcus furiosus
G-1-P dehydrogenase
-
Halobacterium salinarum
G-1-P dehydrogenase
-
Thermoplasma acidophilum
G-1-P dehydrogenase
-
Aeropyrum pernix
G-1-P dehydrogenase
-
Sulfurisphaera tokodaii

Cofactor

Cofactor Comment Organism Structure
NADH preferred cofactor Methanosarcina barkeri
NADH preferred cofactor Pyrococcus sp.
NADH preferred cofactor Methanothermobacter thermautotrophicus
NADH preferred cofactor Pyrococcus furiosus
NADH preferred cofactor Halobacterium salinarum
NADH preferred cofactor Thermoplasma acidophilum
NADH preferred cofactor Aeropyrum pernix
NADH preferred cofactor Sulfurisphaera tokodaii
NADPH less active than NADH Methanosarcina barkeri
NADPH less active than NADH Pyrococcus sp.
NADPH less active than NADH Methanothermobacter thermautotrophicus
NADPH less active than NADH Pyrococcus furiosus
NADPH less active than NADH Halobacterium salinarum
NADPH less active than NADH Thermoplasma acidophilum
NADPH less active than NADH Aeropyrum pernix
NADPH less active than NADH Sulfurisphaera tokodaii