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Literature summary for 1.1.1.26 extracted from

  • Pan, Y.; Ni, R.; Deng, Q.; Huang, X.; Zhang, Y.; Lu, C.; Li, F.; Huang, D.; He, S.; Chen, B.
    Glyoxylate reductase/hydroxypyruvate reductase: a novel prognostic marker for hepatocellular carcinoma patients after curative resection (2013), Pathobiology, 80, 155-162.
    View publication on PubMed

Application

Application Comment Organism
diagnostics enzyme glyoxylate reductase/hydroxypyruvate reductase is a prognostic marker for hepatocellular carcinoma patients after curative resection. Patients with negative GRHPR both in tumor tissues and nontumoral tissues have a significantly shorter survival time than those with positive GRHPR. Multivariate analysis establishes that GRHPR is detected in nontumoral tissues as an independent prognostic factor for patients with hepatocellular carcinoma, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UBQ7
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Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
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Homo sapiens
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Hep-G2 cell
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Homo sapiens
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hepatocellular carcinoma cell enzyme GRHPR is lost in hepatocellular carcinoma (HCC) and proliferative HCC cells Homo sapiens
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HL-7702 cell
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Homo sapiens
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Huh-7 cell GRHPR is reduced in proliferative Huh7 cells Homo sapiens
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additional information immunohistochemic tissue expression analysis of GRHPR, overview. GRHPR shows a lower expression in tumor tissues than in nontumoral tissues. GRHPR is negatively correlated with Ki-67 Homo sapiens
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SMMC-7721 cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
glyoxylate reductase/hydroxypyruvate reductase
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Homo sapiens
GRHPR
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Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deficiency causes primary hyperoxaluria type 2 Homo sapiens
metabolism glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a key enzyme in the glyoxylate cycle Homo sapiens