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Literature summary for 1.1.1.26 extracted from

  • Allan, W.L.; Clark, S.M.; Hoover, G.J.; Shelp, B.J.
    Role of plant glyoxylate reductases during stress: a hypothesis (2009), Biochem. J., 423, 15-22.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information complementation of SSADH-deficient yeast with Arabidopsis thaliana GLYR1, the yeast then grows on 20 mM GABA as the sole nitrogen source and contains elevated levels of 4-hydroxybutyrate Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast isozyme GLYR2 Arabidopsis thaliana 9507
-
cytosol isozyme GLYR1 Arabidopsis thaliana 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glyoxylate + NADPH + H+ Arabidopsis thaliana
-
glycolate + NADP+
-
ir
additional information Arabidopsis thaliana both cytosolic GLYR1 and plastidial GLYR2 catalyse the essentially irreversible, NADPH-based conversion of glyoxylate into glycolate, and can be regulated by the NADPH/NADP ratio ?
-
?
succinic semialdehyde + NADPH + H+ Arabidopsis thaliana succinic semialdehyde-dependent GLYR activity potentially occurs in planta, despite the fact that glyoxylate is the preferred substrate in vitro 4-hydroxybutyrate + NADP+
-
ir

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
NADPH-dependent cytosolic termed GLYR1, and plastidial termed GLYR2 isoforms of succinic semialdehyde/glyoxylate reductase
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-
additional information GLYR activity is found at all developmental stages and in all tissues, and activity is generally higher in vegetative and reproductive organs than in roots Arabidopsis thaliana
-
root
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glyoxylate + NADPH + H+
-
Arabidopsis thaliana glycolate + NADP+
-
ir
glyoxylate + NADPH + H+ preferred substrate Arabidopsis thaliana glycolate + NADP+
-
ir
additional information both cytosolic GLYR1 and plastidial GLYR2 catalyse the essentially irreversible, NADPH-based conversion of glyoxylate into glycolate, and can be regulated by the NADPH/NADP ratio Arabidopsis thaliana ?
-
?
succinic semialdehyde + NADPH + H+ succinic semialdehyde-dependent GLYR activity potentially occurs in planta, despite the fact that glyoxylate is the preferred substrate in vitro Arabidopsis thaliana 4-hydroxybutyrate + NADP+
-
ir

Subunits

Subunits Comment Organism
More GLYR1 structure, molecular modelling, overview Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
GLYR1
-
Arabidopsis thaliana
GLYR2
-
Arabidopsis thaliana
succinic semialdehyde/glyoxylate reductase
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Arabidopsis thaliana
NADPH
-
Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana GLYR isozyme transcript levels increase under various stresses, such as cold and heat up

General Information

General Information Comment Organism
metabolism the enzyme is involved in the glycolate metabolism, as well as the 4-hydroxybutyrate production and the GABA shunt pathway, overview Arabidopsis thaliana
physiological function succinic semialdehyde and glyoxylate are typically generated in leaves via two distinct metabolic pathways, 4-aminobutyrate and glycolate respectively. GLYR isozymes function in the detoxification of both aldehydes during stress and contribute to redox balance, overview Arabidopsis thaliana