BRENDA - Enzyme Database show
show all sequences of 1.1.1.252

Post-aromatic deoxygenation in polyketide biosynthesis: reduction of aromatic rings in the biosynthesis of fungal melanin and anthraquinone

Ichinose, K.; Kiyono, J.; Ebizuka, Y.; Sankawa, U.; Chem. Pharm. Bull. 41, 2015-2021 (1993)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Phialocephala lagerbergii
the enzyme is involved in the post-aromatic deoxygenation process of fungal melanin and pigments
Scytalone + NADP+
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Phialocephala lagerbergii
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Phialocephala lagerbergii
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
-
Phialocephala lagerbergii
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,3,6,8-Tetrahydroxynaphthalene + NADPH
-
9574
Phialocephala lagerbergii
Scytalone + NADP+
-
-
-
-
1,3,6,8-Tetrahydroxynaphthalene + NADPH
the enzyme is involved in the post-aromatic deoxygenation process of fungal melanin and pigments
9574
Phialocephala lagerbergii
Scytalone + NADP+
-
-
-
-
1,3,8-trihydroxynaphthalene + NADPH + H+
-
9574
Phialocephala lagerbergii
vermelone + NADP+
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Phialocephala lagerbergii
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Phialocephala lagerbergii
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1,3,6,8-Tetrahydroxynaphthalene + NADPH
Phialocephala lagerbergii
the enzyme is involved in the post-aromatic deoxygenation process of fungal melanin and pigments
Scytalone + NADP+
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Phialocephala lagerbergii
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
additional information
-
-
Phialocephala lagerbergii
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1,3,6,8-Tetrahydroxynaphthalene + NADPH
-
9574
Phialocephala lagerbergii
Scytalone + NADP+
-
-
-
-
1,3,6,8-Tetrahydroxynaphthalene + NADPH
the enzyme is involved in the post-aromatic deoxygenation process of fungal melanin and pigments
9574
Phialocephala lagerbergii
Scytalone + NADP+
-
-
-
-
1,3,8-trihydroxynaphthalene + NADPH + H+
-
9574
Phialocephala lagerbergii
vermelone + NADP+
-
-
-
-
Other publictions for EC 1.1.1.252
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
723949
Schaetzle
Tetrahydroxynaphthalene reduct ...
Magnaporthe grisea
Angew. Chem. Int. Ed. Engl.
51
2643-2646
2012
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
14
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
697274
Brunskole
Trihydroxynaphthalene reductas ...
Curvularia lunata
Chem. Biol. Interact.
178
259-267
2009
-
1
1
-
-
-
27
1
-
-
-
-
-
7
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
14
-
14
-
1
1
1
-
-
-
14
27
14
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697275
Stojan
Simultaneous binding of coenzy ...
Curvularia lunata
Chem. Biol. Interact.
178
268-273
2009
-
-
1
-
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
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-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
2
-
-
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-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697279
Kristan
Two homologous fungal carbonyl ...
Curvularia lunata
Chem. Biol. Interact.
178
295-302
2009
-
-
1
-
-
-
11
-
-
-
-
1
-
4
-
-
1
-
-
-
-
-
12
-
1
-
-
-
1
-
-
-
-
-
10
-
-
1
-
-
-
-
10
11
-
-
-
-
-
1
-
-
-
1
-
-
-
-
12
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
713194
Zhang
-
Resistance development in rice ...
Magnaporthe grisea
Pestic. Biochem. Physiol.
94
43-47
2009
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
1
-
-
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-
-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
685550
Brunskole
Towards the first inhibitors o ...
Curvularia lunata
Bioorg. Med. Chem.
16
5881-5889
2008
-
1
1
-
-
-
7
-
-
-
-
1
-
4
-
-
1
1
-
-
-
-
2
1
-
-
-
-
1
-
-
1
6
-
-
-
1
1
1
-
-
-
-
7
6
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
688618
Rostkowski
Analysis of conformer stabilit ...
Fungi
J. Phys. Chem. B
111
8314-8320
2007
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
1
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656846
Tsuji
Evidence for involvement of tw ...
Colletotrichum lagenaria
Mycol. Res.
107
854-860
2003
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9577
Thompson
2,3-Dihydro-2,5-dihydroxy-4H-b ...
Magnaporthe grisea
Anal. Biochem.
256
1-6
1998
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
9571
Thompson
Trihydroxynaphthalene reductas ...
Magnaporthe grisea
Biochemistry
36
1852-1860
1997
-
-
-
-
-
-
1
6
-
-
-
1
-
3
-
-
-
-
-
-
-
-
6
-
-
-
-
3
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
1
-
6
-
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
9578
Andersson
A flexible lid controls access ...
Magnaporthe grisea
FEBS Lett.
400
173-176
1997
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
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1
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-
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-
9572
Andersson
Crystallization and preliminar ...
Magnaporthe grisea
Proteins Struct. Funct. Genet.
24
525-527
1996
-
-
-
1
-
-
1
-
-
-
-
-
-
2
-
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-
-
-
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-
-
1
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-
-
-
-
-
2
-
-
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-
2
1
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-
-
1
-
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-
-
-
-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9573
Perpetua
Cloning and characterization o ...
Colletotrichum lagenaria
Mol. Plant Microbe Interact.
9
323-329
1996
-
-
1
-
-
-
-
-
-
-
-
1
-
7
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
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-
1
1
-
-
-
-
-
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-
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-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9576
Andersson
Crystal structure of the terna ...
Magnaporthe grisea
Structure
4
1161-1170
1996
-
-
-
1
-
-
1
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
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1
1
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1
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-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9570
Vidal-Cros
Polyhydroxynaphthalene reducta ...
Magnaporthe grisea
Eur. J. Biochem.
219
985-992
1994
-
-
1
-
-
-
-
-
-
-
3
1
-
4
-
-
1
-
-
-
1
1
3
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
3
1
-
-
-
1
-
-
1
1
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9574
Ichinose
Post-aromatic deoxygenation in ...
Phialocephala lagerbergii
Chem. Pharm. Bull.
41
2015-2021
1993
-
-
-
-
-
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-
-
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1
-
3
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1
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1
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3
-
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1
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1
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1
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1
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1
-
3
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
9575
Viviani
-
Deoxygenation of polyphenols b ...
Magnaporthe oryzae
Bull. Soc. Chim. Fr.
130
395-404
1993
-
-
-
-
-
-
2
3
-
-
-
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-
1
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3
-
-
-
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2
2
-
2
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2
-
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2
-
3
-
-
-
-
-
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-
-
-
3
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
9569
Wheeler
-
The inhibition of melanin bios ...
Magnaporthe oryzae
Exp. Mycol.
12
151-160
1988
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1
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8
-
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1
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1
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3
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1
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1
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1
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8
-
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1
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3
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