BRENDA - Enzyme Database show
show all sequences of 1.1.1.25

Crystallization and preliminary X-ray analysis of shikimate dehydrogenase from Escherichia coli

Maclean, J.; Campbell, S.A.; Pollock, K.; Chackrewarthy, S.; Coggins, J.R.; Lapthorn, A.J.; Acta Crystallogr. Sect. D 56, 512-515 (2000)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene aroE, overexpression in the aroE auxotrophic mutant strain AB2834; overexpression in Escherichia coli K12
Escherichia coli
Crystallization (Commentary)
Crystallization
Organism
; purified recombinant enzyme, 20 mg/ml in 10 mM Tris-HCl, pH 7.6, 0.4 mM DTT, and 2.5 mM NADPH, 20°C, sitting-drop vapour-diffusion method, reservoir solution contains 1.65 M ammonium sulfate, 100 mM cacodylate buffer, pH 5.8, 1.5 ml of protein solution is mixed with an equal volume of reservoir solution, 10-12 days, cryoprotection with 20% v/v glycerol, X-ray diffraction structure determination and analysis at 2.3 A resolution
Escherichia coli
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29400
-
mass spectometry and calculation from DNA sequence
Escherichia coli
29410
-
mass spectrometry
Escherichia coli
29414
-
1 * 29414, mass spectrometry
Escherichia coli
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
shikimate + NADP+
Escherichia coli
-
3-dehydroshikimate + NADPH + H+
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Purification (Commentary)
Commentary
Organism
; recombinant enzyme from aroE auxotrophic mutant strain AB2834 by ammonium sulfate fractionation, anion exchange chromatography, ultrafiltration, and gel filtration
Escherichia coli
Storage Stability
Storage Stability
Organism
-20°C, Tris-HCl, pH 7.5, 0.4 mM DTT, 50% glycerol, long-term
Escherichia coli
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
shikimate + NADP+
-
286396
Escherichia coli
3-dehydroshikimate + NADPH + H+
-
-
-
-
Subunits
Subunits
Commentary
Organism
monomer
1 * 29400, mass spectrometry and gel filtration; 1 * 29414, mass spectrometry
Escherichia coli
More
structure analysis, dynamic light scattering measurements
Escherichia coli
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Escherichia coli
NADPH
-
Escherichia coli
Cloned(Commentary) (protein specific)
Commentary
Organism
gene aroE, overexpression in the aroE auxotrophic mutant strain AB2834; overexpression in Escherichia coli K12
Escherichia coli
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Escherichia coli
NADPH
-
Escherichia coli
Crystallization (Commentary) (protein specific)
Crystallization
Organism
; purified recombinant enzyme, 20 mg/ml in 10 mM Tris-HCl, pH 7.6, 0.4 mM DTT, and 2.5 mM NADPH, 20°C, sitting-drop vapour-diffusion method, reservoir solution contains 1.65 M ammonium sulfate, 100 mM cacodylate buffer, pH 5.8, 1.5 ml of protein solution is mixed with an equal volume of reservoir solution, 10-12 days, cryoprotection with 20% v/v glycerol, X-ray diffraction structure determination and analysis at 2.3 A resolution
Escherichia coli
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29400
-
mass spectometry and calculation from DNA sequence
Escherichia coli
29410
-
mass spectrometry
Escherichia coli
29414
-
1 * 29414, mass spectrometry
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
shikimate + NADP+
Escherichia coli
-
3-dehydroshikimate + NADPH + H+
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
; recombinant enzyme from aroE auxotrophic mutant strain AB2834 by ammonium sulfate fractionation, anion exchange chromatography, ultrafiltration, and gel filtration
Escherichia coli
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, Tris-HCl, pH 7.5, 0.4 mM DTT, 50% glycerol, long-term
Escherichia coli
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
shikimate + NADP+
-
286396
Escherichia coli
3-dehydroshikimate + NADPH + H+
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 29400, mass spectrometry and gel filtration; 1 * 29414, mass spectrometry
Escherichia coli
More
structure analysis, dynamic light scattering measurements
Escherichia coli
Other publictions for EC 1.1.1.25
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724089
Kubota
Characterization of shikimate ...
Corynebacterium glutamicum, Corynebacterium glutamicum JCM 18229
Appl. Microbiol. Biotechnol.
97
8139-8149
2013
-
-
1
-
-
-
2
6
-
-
1
-
-
5
-
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12
1
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6
4
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5
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2
6
-
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4
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6
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2
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-
12
2
-
-
-
6
4
-
-
-
1
1
1
1
6
6
725977
Lee
High-resolution structure of s ...
Thermotoga maritima, Thermotoga maritima ATCC 43589
Mol. Cells
33
229-233
2012
-
-
-
1
-
-
-
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-
-
-
-
-
4
-
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1
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721203
Lee
Overexpression, crystallizatio ...
Archaeoglobus fulgidus, Archaeoglobus fulgidus ATCC 49558
Acta Crystallogr. Sect. F
67
1556-1558
2011
-
1
1
1
-
-
-
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-
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2
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4
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1
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1
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1
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-
723859
Lee
Overexpression, crystallizatio ...
Thermotoga maritima, Thermotoga maritima ATCC 43589
Acta Crystallogr. Sect. F
67
824-826
2011
-
-
1
1
-
-
-
-
-
-
2
-
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5
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1
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1
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1
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704148
Cao
Effect of BTH on anthocyanin c ...
Fragaria x ananassa
J. Agric. Food Chem.
58
5801-5805
2010
2
-
-
-
-
-
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1
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2
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2
3
2
2
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2
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1
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2
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2
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2
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1
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2
3
2
2
-
2
-
-
-
1
-
-
-
-
1
1
-
-
-
697894
Han
X-ray crystallographic and enz ...
Staphylococcus epidermidis RP62A
FEBS J.
276
1125-1139
2009
-
-
1
1
1
-
-
5
-
-
2
-
-
2
-
-
1
-
-
-
-
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2
1
-
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3
1
1
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1
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1
1
1
1
-
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-
5
-
-
2
-
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1
-
-
-
-
2
1
-
-
-
3
1
1
-
-
-
-
-
-
-
-
698320
Rodrigues
Homogeneous recombinant Mycoba ...
Mycobacterium tuberculosis
Int. J. Biol. Macromol.
45
200-205
2009
-
-
1
-
6
-
-
2
1
-
1
-
-
2
-
-
1
-
-
-
2
-
1
1
-
-
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1
-
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1
-
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6
-
-
-
-
2
1
-
1
-
-
-
-
1
-
-
2
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
699631
Barcellos
Structural studies of shikimat ...
Bacillus anthracis
J. Mol. Model.
15
147-155
2009
-
-
-
-
-
-
-
-
-
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1
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5
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1
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1
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1
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1
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1
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1
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1
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-
-
-
711616
Rodrigues
The conserved Lysine69 residue ...
Mycobacterium tuberculosis, no activity in Homo sapiens
BMC Res. Notes
2
227
2009
-
1
-
-
1
-
-
5
-
-
-
1
-
4
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1
-
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2
1
1
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2
1
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2
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1
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2
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1
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5
-
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1
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-
-
-
2
1
1
-
-
2
1
-
-
-
-
2
2
-
4
4
684153
Schoepe
1.6 A structure of an NAD(+)-d ...
Corynebacterium glutamicum
Acta Crystallogr. Sect. D
64
803-809
2008
-
-
-
1
-
-
-
2
-
-
-
-
-
1
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1
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2
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2
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2
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2
1
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2
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-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
689956
Arcuri
Structural studies of shikimat ...
Mycobacterium tuberculosis
Proteins
72
720-730
2008
-
-
-
1
-
-
-
-
-
-
-
-
-
7
-
-
-
-
1
-
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1
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1
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1
-
-
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-
1
-
-
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-
-
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-
-
-
-
694093
Singh
A phylogenomic analysis of the ...
Pseudomonas putida, Pseudomonas putida KT2240, Pseudomonas putida KT2440
Mol. Biol. Evol.
25
2221-2232
2008
-
-
2
-
-
-
-
16
-
-
-
8
-
8
-
-
2
-
-
-
-
2
14
-
1
-
-
22
1
-
-
3
-
-
-
-
-
7
7
-
-
-
-
-
-
16
-
-
-
8
-
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7
-
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-
2
14
-
4
-
-
22
4
-
-
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-
-
-
-
-
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681134
Ding
Functional analysis of the ess ...
Nicotiana tabacum
J. Exp. Bot.
58
2053-2067
2007
-
-
1
-
1
-
-
2
3
-
-
6
-
3
-
-
1
-
-
1
-
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11
-
2
-
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-
3
-
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2
-
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-
3
4
-
3
-
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-
4
3
-
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6
-
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2
-
2
-
-
11
-
4
-
-
-
4
-
-
-
-
-
-
-
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-
684670
Fonseca
Kinetic and chemical mechanism ...
Mycobacterium tuberculosis
Arch. Biochem. Biophys.
457
123-133
2007
-
-
-
-
-
-
2
2
-
-
-
-
-
2
-
-
-
1
-
-
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-
1
-
-
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-
1
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2
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2
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1
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1
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685190
Gan
Structural and biochemical ana ...
Aquifex aeolicus
Biochemistry
46
9513-9522
2007
-
-
1
1
-
-
-
2
-
-
-
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-
4
-
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1
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1
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1
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1
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1
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2
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1
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1
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-
686243
Singh
-
The DHQ-dehydroshikimate-SDH-s ...
Arabidopsis thaliana
Cryst. Growth Des.
7
2153-2160
2007
-
-
1
1
8
-
-
16
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
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16
-
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1
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1
8
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16
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-
1
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16
-
-
-
-
-
-
-
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688379
Bagautdinov
Crystal structures of shikimat ...
Thermus thermophilus
J. Mol. Biol.
373
424-438
2007
-
-
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1
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4
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667097
Schoepe
Cloning, expression, purificat ...
Corynebacterium glutamicum
Acta Crystallogr. Sect. F
F62
635-637
2006
-
-
1
1
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3
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1
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1
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1
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667700
Singh
Structure of Arabidopsis dehyd ...
Arabidopsis thaliana
Biochemistry
45
10406
2006
-
-
1
1
10
-
-
18
-
-
-
2
-
1
-
-
-
1
-
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1
-
3
-
1
-
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18
1
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2
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1
2
1
10
-
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-
-
18
-
-
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2
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1
-
3
-
1
-
-
18
1
-
-
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-
668019
Adachi
Purification and properties of ...
Gluconobacter oxydans, Gluconobacter oxydans IFO 3244
Biosci. Biotechnol. Biochem.
70
2786-2789
2006
-
-
-
-
-
-
-
-
-
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2
2
-
6
-
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-
1
-
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2
2
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2
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2
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2
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2
2
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1
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2
2
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2
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668576
Han
Biochemical characterization a ...
Helicobacter pylori, Helicobacter pylori SS1
FEBS J.
273
4682-4692
2006
-
-
1
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6
3
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2
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4
-
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1
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1
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6
1
1
1
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3
1
1
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4
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5
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1
4
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5
6
-
3
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2
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1
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1
-
6
1
1
1
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3
1
1
-
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670786
Fonseca
Functional shikimate dehydroge ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Protein Expr. Purif.
46
429-437
2006
-
-
1
-
-
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-
5
-
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5
-
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7
-
-
1
-
-
-
1
-
1
2
1
-
2
4
1
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1
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2
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1
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657359
Padyana
Crystal structure of shikimate ...
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670901
Vogan
Shikimate dehydrogenase struct ...
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Structure
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2003
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1
1
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Magalhaes
Cloning and expression of func ...
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1
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1
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286396
Maclean
Crystallization and preliminar ...
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1
1
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1
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1
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286398
Diaz
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Shikimate dehydrogenase from p ...
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4
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286397
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Purification and properties of ...
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1
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1
1
1
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1
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5
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1
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1
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The purification of shikimate ...
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1
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286394
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7
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286387
Lourenco
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Partial purification and some ...
Solanum lycopersicum
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23
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2
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3
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3
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8
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5466
Polley
Purification and characterizat ...
Physcomitrella patens
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1978
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1
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286388
Koshiba
Purification of two forms of t ...
Vigna mungo
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Jacobson
Purification and stability of ...
Neurospora crassa
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-
Changes in activity of shikima ...
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Sanderson
5-Dehydroshikimate reductase i ...
Camellia sinensis
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Aromatic biosynthesis in highe ...
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Aromatic biosynthesis. XIV. 5- ...
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