BRENDA - Enzyme Database show
show all sequences of 1.1.1.247

Stereoselective reduction of codeinone, the penultimate enzymic step during morphine biosynthesis in Papaver somniferum

Lenz, R.; Zenk, M.H.; Tetrahedron Lett. 36, 2449-2452 (1995)
No PubMed abstract available

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
gel filtration
Papaver somniferum
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Codeinone + NADPH
Papaver somniferum
important regulating function in morphine biosynthesis
Codeine + NADP+
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Papaver somniferum
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cell culture
-
Papaver somniferum
-
plant capsule
-
Papaver somniferum
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Codeinone + NADPH
no reaction with NADH and NAD+
9553
Papaver somniferum
Codeine + NADP+
-
9553
Papaver somniferum
-
Codeinone + NADPH
important regulating function in morphine biosynthesis
9553
Papaver somniferum
Codeine + NADP+
-
-
-
-
Hydrocodone + NADPH
110% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Hydromorphone + NADPH
90% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Naloxone + NADPH
80% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Naltrexone + NADPH
30% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
monomer
34000-35000, SDS-PAGE
Papaver somniferum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
gel filtration
Papaver somniferum
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Codeinone + NADPH
Papaver somniferum
important regulating function in morphine biosynthesis
Codeine + NADP+
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cell culture
-
Papaver somniferum
-
plant capsule
-
Papaver somniferum
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Codeinone + NADPH
no reaction with NADH and NAD+
9553
Papaver somniferum
Codeine + NADP+
-
9553
Papaver somniferum
-
Codeinone + NADPH
important regulating function in morphine biosynthesis
9553
Papaver somniferum
Codeine + NADP+
-
-
-
-
Hydrocodone + NADPH
110% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Hydromorphone + NADPH
90% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Naloxone + NADPH
80% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Naltrexone + NADPH
30% of the reaction with codeinone
9553
Papaver somniferum
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
34000-35000, SDS-PAGE
Papaver somniferum
Other publictions for EC 1.1.1.247
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724646
Sharafi
Metabolic engineering of morph ...
Papaver somniferum
Biotechnol. Lett.
35
445-453
2013
-
1
1
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1
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2
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3
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1
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1
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1
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689454
Apuya
Enhancement of alkaloid produc ...
Eschscholzia californica, Papaver somniferum
Plant Biotechnol. J.
6
160-175
2008
2
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2
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2
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689451
Larkin
Increasing morphinan alkaloid ...
Papaver somniferum
Plant Biotechnol. J.
5
26-37
2007
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1
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670561
Samanani
The role of phloem sieve eleme ...
Papaver somniferum
Plant J.
47
547-563
2006
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-
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1
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4
-
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1
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2
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2
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1
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1
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2
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670562
Ziegler
Comparative transcript and alk ...
Papaver somniferum
Plant J.
48
177-192
2006
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5
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1
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660256
Alcantara
Sanguinarine biosynthesis is a ...
Papaver somniferum
Plant Physiol.
138
173-183
2005
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657166
Weid
The roles of latex and the vas ...
Papaver somniferum
Proc. Natl. Acad. Sci. USA
101
13957-13962
2004
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656969
Bird
A tale of three cell types: al ...
Papaver somniferum
Plant Cell
15
2626-2635
2003
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1
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4
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1
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9551
Lenz
Purification and properties of ...
Papaver somniferum
Eur. J. Biochem.
233
132-139
1995
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15
2
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1
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2
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1
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5
1
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11
1
2
2
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15
2
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1
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5
1
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11
1
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2
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2
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9553
Lenz
-
Stereoselective reduction of c ...
Papaver somniferum
Tetrahedron Lett.
36
2449-2452
1995
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1
1
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1
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2
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6
1
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1
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9552
Gollwitzer
-
The transformation of neopinon ...
Papaver somniferum
Tetrahedron Lett.
34
5703-5706
1993
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