BRENDA - Enzyme Database show
show all sequences of 1.1.1.239

Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers

Matsunaga, T.; Hojo, A.; Yamane, Y.; Endo, S.; El-Kabbani, O.; Hara, A.; Chem. Biol. Interact. 202, 234-242 (2013)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression. The resistance lowers the sensitivity toward cellular damages evoked by oxidative stress-derived aldehydes, 4-hydroxy-2-nonenal and 4-oxo-2-nonenal that are detoxified by AKR1C1 and AKR1C3. Overexpression of AKR1C1 or AKR1C3 in the parental HCT15 cells mitigates the cytotoxicity of the aldehydes and cisplatin. Knockdown of both AKR1C1 and AKR1C3 in the resistant cells or treatment of the cells with specific inhibitors of the aldo-keto reductases increases the sensitivity to ciplatin toxicity. Pretreatment of the resistant cells with proteasome inhibitor Z-Leu-Leu-Leu-al augments the cisplatin sensitization elicited by aldo-keto reductase inhibitors
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0031
-
4-oxo-2-nonenal
pH 7.4, 25°C
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P42330
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
colon
-
Homo sapiens
-
HCT-15 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-oxo-2-nonenal + NADPH + H+
-
724719
Homo sapiens
4-hydroxy-2-nonenal + NADP+
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.148
-
4-oxo-2-nonenal
pH 7.4, 25°C
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression. The resistance lowers the sensitivity toward cellular damages evoked by oxidative stress-derived aldehydes, 4-hydroxy-2-nonenal and 4-oxo-2-nonenal that are detoxified by AKR1C1 and AKR1C3. Overexpression of AKR1C1 or AKR1C3 in the parental HCT15 cells mitigates the cytotoxicity of the aldehydes and cisplatin. Knockdown of both AKR1C1 and AKR1C3 in the resistant cells or treatment of the cells with specific inhibitors of the aldo-keto reductases increases the sensitivity to ciplatin toxicity. Pretreatment of the resistant cells with proteasome inhibitor Z-Leu-Leu-Leu-al augments the cisplatin sensitization elicited by aldo-keto reductase inhibitors
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0031
-
4-oxo-2-nonenal
pH 7.4, 25°C
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
colon
-
Homo sapiens
-
HCT-15 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-oxo-2-nonenal + NADPH + H+
-
724719
Homo sapiens
4-hydroxy-2-nonenal + NADP+
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.148
-
4-oxo-2-nonenal
pH 7.4, 25°C
Homo sapiens
Expression
Organism
Commentary
Expression
Homo sapiens
exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression
up
General Information
General Information
Commentary
Organism
physiological function
exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression. The resistance lowers the sensitivity toward cellular damages evoked by oxidative stress-derived aldehydes, 4-hydroxy-2-nonenal and 4-oxo-2-nonenal that are detoxified by AKR1C1 and AKR1C3. Overexpression of AKR1C1 or AKR1C3 in the parental HCT15 cells mitigates the cytotoxicity of the aldehydes and cisplatin. Knockdown of both AKR1C1 and AKR1C3 in the resistant cells or treatment of the cells with specific inhibitors of the aldo-keto reductases increases the sensitivity to ciplatin toxicity
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression. The resistance lowers the sensitivity toward cellular damages evoked by oxidative stress-derived aldehydes, 4-hydroxy-2-nonenal and 4-oxo-2-nonenal that are detoxified by AKR1C1 and AKR1C3. Overexpression of AKR1C1 or AKR1C3 in the parental HCT15 cells mitigates the cytotoxicity of the aldehydes and cisplatin. Knockdown of both AKR1C1 and AKR1C3 in the resistant cells or treatment of the cells with specific inhibitors of the aldo-keto reductases increases the sensitivity to ciplatin toxicity
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression
up
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
47.8
-
4-oxo-2-nonenal
pH 7.4, 25°C
Homo sapiens
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
47.8
-
4-oxo-2-nonenal
pH 7.4, 25°C
Homo sapiens
Other publictions for EC 1.1.1.239
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724719
Matsunaga
Pathophysiological roles of al ...
Homo sapiens
Chem. Biol. Interact.
202
234-242
2013
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724915
Heinrich
Synthesis and structure-activi ...
Homo sapiens
Eur. J. Med. Chem.
62
738-744
2013
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724916
Gazvoda
2,3-diarylpropenoic acids as s ...
Homo sapiens
Eur. J. Med. Chem.
62
89-97
2013
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723866
Jackson
Structure of AKR1C3 with 3-phe ...
Homo sapiens
Acta Crystallogr. Sect. F
68
409-413
2012
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1
1
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724533
Chen
Crystal structures of AKR1C3 c ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
3492-3497
2012
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724538
Sinreih
N-Benzoyl anthranilic acid der ...
Homo sapiens
Bioorg. Med. Chem. Lett.
22
5948-5951
2012
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4
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725153
Miller
Aldo-keto reductase family 1 m ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
5
278-289
2012
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1
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8
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725671
Brozic
Selective inhibitors of aldo-k ...
Homo sapiens
J. Med. Chem.
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7417-7424
2012
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1
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725825
Byrns
Overexpression of aldo-keto re ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
130
7-15
2012
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1
1
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724517
Adeniji
Discovery of substituted 3-(ph ...
Homo sapiens
Bioorg. Med. Chem. Lett.
21
1464-1468
2011
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711670
Guise
The bioreductive prodrug PR-10 ...
Homo sapiens
Cancer Res.
70
1573-1584
2010
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1
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1
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1
-
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712882
Byrns
Aldo-keto reductase 1C3 expres ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
118
177-187
2010
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1
1
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1
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1
1
713574
Ashley
Developmental evaluation of al ...
Homo sapiens
Urology
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67-72
2010
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1
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1
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725152
Zakharov
Suppressed expression of type ...
Homo sapiens
Int. J. Clin. Exp. Pathol.
3
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2010
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1
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712571
Nakamura
Type 5 17ß-hydroxysteroid deh ...
Homo sapiens
J. Clin. Endocrinol. Metab.
94
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Azzarello
Tissue distribution of human A ...
Homo sapiens, Rattus norvegicus
J. Histochem. Cytochem.
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2008
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670259
Ngatcha
3beta-Alkyl-androsterones as i ...
Homo sapiens
Mol. Cell. Endocrinol.
248
225-232
2006
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3
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1
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1
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673341
Fung
Increased expression of type 2 ...
Homo sapiens
Endocr. Relat. Cancer
13
169-180
2006
-
-
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1
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287209
Krazeisen
Phytoestrogens inhibit human 1 ...
Homo sapiens
Mol. Cell. Endocrinol.
171
151-162
2001
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1
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9
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1
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3
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2
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5
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5
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1
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1
1
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9
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1
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3
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5
-
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5
-
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287210
Stupans
Testosterone dehydrogenase act ...
Homo sapiens, Macropus eugenii, Phascolarctos cinereus, Rattus norvegicus
Comp. Biochem. Physiol. B
125
245-250
2000
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1
4
4
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4
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10
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4
7
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4
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4
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4
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1
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4
4
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4
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4
7
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4
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287211
Carre
Characterization and solubizat ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
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265-267
1993
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2
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1
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1
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2
1
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1
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1
2
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1
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1
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287212
Dumont
Expression of human 17beta-hyd ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
41
605-608
1992
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1
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1
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1
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7
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3
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1
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1
1
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1
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7
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3
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286355
Sawada
Kinetic and stereochemical cha ...
Mesocricetus auratus
J. Biochem.
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770-775
1991
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4
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1
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1
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1
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1
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4
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1
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1
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286354
Ohmura
Demonstration of 3alpha(17beta ...
Mesocricetus auratus
Biochem. J.
266
583-589
1990
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11
13
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1
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1
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1
1
1
10
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1
12
1
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4
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4
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11
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13
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1
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1
1
1
10
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1
12
1
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287213
Itagaki
Purification and characterizat ...
Ilyonectria destructans
J. Biochem.
103
1039-1044
1988
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6
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2
1
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1
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1
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1
1
3
1
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1
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2
1
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1
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1
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6
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2
1
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1
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1
1
3
1
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1
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2
1
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287214
Payne
Isolation of novel microbiol 3 ...
Alcaligenes sp.
J. Biol. Chem.
260
13648-13655
1985
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6
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3
1
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1
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1
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1
1
13
1
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1
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2
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1
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1
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6
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3
1
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1
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1
1
13
1
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1
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2
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287215
Blomquist
Microsomal 17beta-hydroxystero ...
Cavia porcellus
J. Steroid Biochem.
8
193-198
1977
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-
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1
1
4
1
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1
1
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1
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1
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1
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1
1
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1
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1
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1
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1
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4
1
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1
1
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1
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1
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1
1
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287216
Markert
-
Enzyminduktion bei Streptomyce ...
Streptomyces exfoliatus
Hoppe-Seyler's Z. Physiol. Chem.
356
1843-1852
1975
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2
3
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1
1
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1
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1
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8
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1
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1
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1
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1
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2
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3
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1
1
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1
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8
-
1
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1
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287217
Ghraf
11beta- und 17beta-Hydroxyster ...
Rattus norvegicus
Hoppe-Seyler's Z. Physiol. Chem.
354
299-305
1973
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1
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1
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1
1
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1
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1
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1
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1
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1
1
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1
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287218
Endahl
-
Separation of a triphosphopyri ...
Cavia porcellus
J. Biol. Chem.
235
2793-2796
1960
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8
1
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1
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1
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1
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1
1
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1
1
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1
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1
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8
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1
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1
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1
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1
1
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1
1
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287219
Villee
Some properties of the pyridin ...
Cavia porcellus
J. Biol. Chem.
235
3615-3619
1960
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1
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1
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1
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1
1
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1
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1
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1
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1
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1
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1
1
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1
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287220
Sweat
Preparation and characterizati ...
Bos taurus
J. Biol. Chem.
185
75-84
1950
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1
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1
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1
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1
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1
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1
1
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1
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1
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1
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1
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1
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1
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1
1
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