BRENDA - Enzyme Database show
show all sequences of 1.1.1.237

Hydroxyphenylpyruvate reductase from cell suspension cultures of Coleus blumei Benth

Häusler, E.; Petersen, M.; Alfermann, A.W.; Z. Naturforsch. C 46, 371-376 (1991)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
4-hydroxyphenylpyruvate
substrate inhibition
Solenostemon scutellarioides
dihydroxyphenylpyruvate
substrate inhibition
Solenostemon scutellarioides
p-Coumaroyl-CoA
50% inhibition at 0.5 mM
Solenostemon scutellarioides
pyruvate
competitive inhibition
Solenostemon scutellarioides
rosmarinic acid
competitive inhibition
Solenostemon scutellarioides
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
10
-
4-hydroxyphenylpyruvate
pH 7
Solenostemon scutellarioides
95
-
NADPH
pH 7
Solenostemon scutellarioides
130
-
3,4-Dihydroxyphenylpyruvate
pH 7
Solenostemon scutellarioides
190
-
NADH
pH 7
Solenostemon scutellarioides
250
-
3-methoxy-4-hydroxyphenylpyruvate
pH 7
Solenostemon scutellarioides
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-(4-hydroxyphenyl)lactate + NAD+
Solenostemon scutellarioides
-
4-hydroxyphenylpyruvate + NADH
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Solenostemon scutellarioides
-
-
-
Storage Stability
Storage Stability
Organism
-20°C, loss of 30% activity after 1 month
Solenostemon scutellarioides
-20°C, loss of 85% activity after 10 weeks
Solenostemon scutellarioides
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3,4-dihydroxyphenylpyruvate + NADH
-
286350
Solenostemon scutellarioides
3-(3,4-dihydroxyphenyl)lactate + NAD+
-
286350
Solenostemon scutellarioides
r
3-(4-hydroxyphenyl)lactate + NAD+
-
286350
Solenostemon scutellarioides
4-hydroxyphenylpyruvate + NADH
-
-
-
?
3-methoxy-4-hydroxyphenylpyruvate + NADH
-
286350
Solenostemon scutellarioides
3-(3-methoxy-4-hydroxyphenyl)lactate + NAD+
-
-
-
?
4-hydroxyphenylpyruvate + NADH
-
286350
Solenostemon scutellarioides
3-(4-hydroxyphenyl)lactate + NAD+
-
286350
Solenostemon scutellarioides
r
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
37
-
Solenostemon scutellarioides
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
7
-
Solenostemon scutellarioides
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
4-hydroxyphenylpyruvate
substrate inhibition
Solenostemon scutellarioides
dihydroxyphenylpyruvate
substrate inhibition
Solenostemon scutellarioides
p-Coumaroyl-CoA
50% inhibition at 0.5 mM
Solenostemon scutellarioides
pyruvate
competitive inhibition
Solenostemon scutellarioides
rosmarinic acid
competitive inhibition
Solenostemon scutellarioides
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
10
-
4-hydroxyphenylpyruvate
pH 7
Solenostemon scutellarioides
95
-
NADPH
pH 7
Solenostemon scutellarioides
130
-
3,4-Dihydroxyphenylpyruvate
pH 7
Solenostemon scutellarioides
190
-
NADH
pH 7
Solenostemon scutellarioides
250
-
3-methoxy-4-hydroxyphenylpyruvate
pH 7
Solenostemon scutellarioides
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-(4-hydroxyphenyl)lactate + NAD+
Solenostemon scutellarioides
-
4-hydroxyphenylpyruvate + NADH
-
-
?
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, loss of 30% activity after 1 month
Solenostemon scutellarioides
-20°C, loss of 85% activity after 10 weeks
Solenostemon scutellarioides
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3,4-dihydroxyphenylpyruvate + NADH
-
286350
Solenostemon scutellarioides
3-(3,4-dihydroxyphenyl)lactate + NAD+
-
286350
Solenostemon scutellarioides
r
3-(4-hydroxyphenyl)lactate + NAD+
-
286350
Solenostemon scutellarioides
4-hydroxyphenylpyruvate + NADH
-
-
-
?
3-methoxy-4-hydroxyphenylpyruvate + NADH
-
286350
Solenostemon scutellarioides
3-(3-methoxy-4-hydroxyphenyl)lactate + NAD+
-
-
-
?
4-hydroxyphenylpyruvate + NADH
-
286350
Solenostemon scutellarioides
3-(4-hydroxyphenyl)lactate + NAD+
-
286350
Solenostemon scutellarioides
r
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
37
-
Solenostemon scutellarioides
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
7
-
Solenostemon scutellarioides
Other publictions for EC 1.1.1.237
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724428
Fujii
Novel fungal phenylpyruvate re ...
Wickerhamia fluorescens, Wickerhamia fluorescens TK1
Biochim. Biophys. Acta
1814
1669-1676
2011
-
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1
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5
6
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3
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2
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1
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10
1
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6
1
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4
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1
4
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5
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6
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3
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-
1
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10
1
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6
1
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-
1
1
1
1
6
6
723825
Janiak
Structure and substrate dockin ...
Solenostemon scutellarioides
Acta Crystallogr. Sect. D
66
593-603
2010
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1
1
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1
1
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3
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1
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1
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5
2
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3
1
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1
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5
2
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2
2
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700368
Qian
Influence of growth regulators ...
Solenostemon scutellarioides
Nat. Prod. Res.
23
127-137
2009
1
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1
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700648
Xiao
Methyl jasmonate dramatically ...
Salvia miltiorrhiza
Physiol. Plant.
137
1-9
2009
1
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1
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657023
Kim
Purification, cloning and func ...
Solenostemon scutellarioides
Plant Mol. Biol.
54
311-323
2004
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1
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1
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3
1
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5
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1
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1
1
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3
1
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1
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1
1
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1
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1
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1
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1
1
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3
1
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286351
Petersen
-
The biosynthesis of rosmarinic ...
Solenostemon scutellarioides
Plant Cell Tissue Organ Cult.
38
171 - 179
1994
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4
4
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1
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1
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1
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286352
Petersen
-
Proposed biosynthetic pathway ...
Solenostemon scutellarioides
Planta
189
10-14
1993
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1
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286350
Häusler
-
Hydroxyphenylpyruvate reductas ...
Solenostemon scutellarioides
Z. Naturforsch. C
46
371-376
1991
-
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-
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5
5
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1
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1
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2
4
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1
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1
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5
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5
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1
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2
4
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1
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1
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286349
Petersen
-
Two new enzymes of rosmarinic ...
Solenostemon scutellarioides
Z. Naturforsch. C
43
501-504
1988
2
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