General Stability | Organism |
---|---|
freezing and thawing: repeatedly, slow loss of activity | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0134 | - |
NADP+ | - |
Oryctolagus cuniculus | |
0.278 | - |
prostaglandin I2 | - |
Oryctolagus cuniculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
62000 | - |
gel filtration | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ | Oryctolagus cuniculus | - |
(5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
19.9 | - |
- |
Oryctolagus cuniculus |
Storage Stability | Organism |
---|---|
stable for months when frozen | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ | - |
Oryctolagus cuniculus | (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH | - |
? | |
(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ | i.e. prostaglandin I2, prostacyclin | Oryctolagus cuniculus | (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH | i.e. 15-keto prostaglandin I2 | ? | |
6-keto-prostaglandin F1alpha + NADP+ | at 1.8% the reaction rate of prostaglandin I2 | Oryctolagus cuniculus | 6,15-diketoprostaglandin F2alpha + NADPH | - |
? | |
additional information | enzyme catalyzes reduction of 9-keto group in prostaglandin E2 at less than 1% the rate of prostaglandin I2 oxidation | Oryctolagus cuniculus | ? | - |
? | |
prostaglandin B1 + NADP+ | at 8% the reaction rate of prostaglandin I2 | Oryctolagus cuniculus | 15-ketoprostaglandin B1 + NADPH + H+ | - |
? | |
prostaglandin E2 + NADP+ | at 4% the reaction rate of prostaglandin I2 | Oryctolagus cuniculus | 15-ketoprostaglandin E2 + NADPH + H+ | - |
? | |
prostaglandin F2alpha + NADP+ | at 2.2% the reaction rate of prostaglandin I2 | Oryctolagus cuniculus | 15-ketoprostaglandin F2alpha + NADPH + H+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10.3 | - |
assay at | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no activity with NAD+ | Oryctolagus cuniculus | |
NADP+ | - |
Oryctolagus cuniculus |