BRENDA - Enzyme Database show
show all sequences of 1.1.1.23

Target-specific anti-fungal discovery by targeting Geotrichum candidum histidinol dehydrogenase: a hybrid approach

Pahwa, S.; Chavan, A.G.; Jain, R.; Roy, N.; Chem. Biol. Drug Des. 72, 229-234 (2008)

Data extracted from this reference:

Application
Application
Commentary
Organism
drug development
histidinol dehydrogenase is a suitable target for not only for Geotrichum candidum but also for related species, wherby compounds identified can serve as a valuable lead for development of novel non-classical antifungal therapy, notably against strain like Candida rapidly becoming resistant to conventional therapy
Geotrichum candidum
Cloned(Commentary)
Commentary
Organism
-
Geotrichum candidum
Inhibitors
Inhibitors
Commentary
Organism
Structure
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
weaker inhibitor
Geotrichum candidum
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
most active inhibitor
Geotrichum candidum
imidazole-4-carboxylic acid
most active inhibitor
Geotrichum candidum
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
weaker inhibitor
Geotrichum candidum
methyl 3-(1H-imidazol-4-yl)propanoate
-
Geotrichum candidum
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
-
Geotrichum candidum
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
-
Geotrichum candidum
additional information
5% dimethyl sulfoxide or methyl N-[(trifluoromethoxy)carbonyl]-L-histidinate trifluoroacetate fails to exert any growth inhibitory activity
Geotrichum candidum
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Geotrichum candidum
-
-
-
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0052
-
-
Geotrichum candidum
methyl 3-(1H-imidazol-4-yl)propanoate
0.0064
-
-
Geotrichum candidum
imidazole-4-carboxylic acid
0.0106
-
-
Geotrichum candidum
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
0.0242
-
-
Geotrichum candidum
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
0.0293
-
-
Geotrichum candidum
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
0.0587
-
-
Geotrichum candidum
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
0.1222
-
-
Geotrichum candidum
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
Application (protein specific)
Application
Commentary
Organism
drug development
histidinol dehydrogenase is a suitable target for not only for Geotrichum candidum but also for related species, wherby compounds identified can serve as a valuable lead for development of novel non-classical antifungal therapy, notably against strain like Candida rapidly becoming resistant to conventional therapy
Geotrichum candidum
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Geotrichum candidum
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.0052
-
-
Geotrichum candidum
methyl 3-(1H-imidazol-4-yl)propanoate
0.0064
-
-
Geotrichum candidum
imidazole-4-carboxylic acid
0.0106
-
-
Geotrichum candidum
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
0.0242
-
-
Geotrichum candidum
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
0.0293
-
-
Geotrichum candidum
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
0.0587
-
-
Geotrichum candidum
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
0.1222
-
-
Geotrichum candidum
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(7R)-1,3-diiodo-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylic acid
weaker inhibitor
Geotrichum candidum
7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one
most active inhibitor
Geotrichum candidum
imidazole-4-carboxylic acid
most active inhibitor
Geotrichum candidum
methyl (7R)-1-chloro-5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine-7-carboxylate
weaker inhibitor
Geotrichum candidum
methyl 3-(1H-imidazol-4-yl)propanoate
-
Geotrichum candidum
methyl N-(ethoxycarbonyl)-1-methyl-L-histidinate
-
Geotrichum candidum
methyl N-(methoxycarbonyl)-3-methyl-L-histidinate
-
Geotrichum candidum
additional information
5% dimethyl sulfoxide or methyl N-[(trifluoromethoxy)carbonyl]-L-histidinate trifluoroacetate fails to exert any growth inhibitory activity
Geotrichum candidum
Other publictions for EC 1.1.1.23
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
721426
Nunes
Molecular, kinetic, thermodyna ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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Turtaut
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Brucella sp.
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Abdo
Anti-virulence strategy agains ...
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Structure based design of nove ...
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Abdo
Brucella suis histidinol dehyd ...
Brucella suis
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23
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2008
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Pahwa
Target-specific anti-fungal di ...
Geotrichum candidum
Chem. Biol. Drug Des.
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229-234
2008
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Targeting of the Brucella suis ...
Brucella suis
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Mechanism of action and NAD+-b ...
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Mechanism of Salmonella typhim ...
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Effect of excess cadmium ion o ...
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286325
Nagai
Histidinol dehydrogenase loses ...
Salmonella enterica subsp. enterica serovar Typhimurium
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1994
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286329
Nagai
Purification and characterizat ...
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24
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286330
Grubmeyer
A cysteine residue (cysteine-1 ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochemistry
25
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1986
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286331
Grisch
Binding of histidinal to histi ...
Salmonella enterica subsp. enterica serovar Typhimurium
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305-308
1985
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286332
Andorn
Purification and properties of ...
Escherichia coli
J. Gen. Microbiol.
128
579-584
1982
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1
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286333
Feingold
-
Pyridine nucleotide-linked fou ...
Salmonella enterica subsp. enterica serovar Typhimurium
Trends Biochem. Sci.
6
103-105
1981
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2
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286334
Burger
Evidence for an essential lysi ...
Salmonella enterica subsp. enterica serovar Typhimurium
Eur. J. Biochem.
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125-130
1981
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286335
Burger
The catalytically active form ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochem. J.
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1979
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286336
Bitar
Histidinol dehydrogenase from ...
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Biochim. Biophys. Acta
493
429-440
1977
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286337
Lindsay
Purification and properties of ...
Bacillus caldolyticus, Bacillus subtilis, Bacillus subtilis HT1, Geobacillus stearothermophilus, Sporosarcina psychrophila
Biochem. J.
165
247-253
1977
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286338
Yang
Studies on histidinol dehydrog ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Mol. Biol.
81
517-519
1973
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286339
Loper
Purification and properties of ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
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788-795
1965
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286340
Adams
The enzymatic synthesis of his ...
Escherichia coli, Paenarthrobacter histidinolovorans
J. Biol. Chem.
209
829-846
1954
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