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Literature summary for 1.1.1.23 extracted from

  • Abdo, M.R.; Joseph, P.; Boigegrain, R.A.; Montero, J.L.; Kohler, S.; Winum, J.Y.
    Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide (2008), J. Enzyme Inhib. Med. Chem., 23, 357-361.
    View publication on PubMed
Search for more literature for 1.1.1.23

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Brucella suis

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-(naphthalen-2-ylsulfonyl)propanehydrazide
-
 Brucella suis
(2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methylphenyl)sulfonyl]propanehydrazide
-
 Brucella suis
(2S)-2-amino-N'-(biphenyl-4-ylsulfonyl)-3-(1H-imidazol-4-yl)propanehydrazide
-
 Brucella suis
(2S)-2-amino-N'-[(4-bromophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide
-
 Brucella suis
(S)-3-amino-1-(4-(benzyloxy)phenyl)-4-(1H-imidazol-4-yl)butan-2-one
-
 Brucella suis
(S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-4-yl)butan-2-one
-
 Brucella suis
(S)-3-amino-1-(4-chlorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
-
 Brucella suis
(S)-3-amino-1-(4-fluorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
-
 Brucella suis
(S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-phenoxyphenyl)butan-2-one
-
 Brucella suis
(S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yl)butan-2-one
-
 Brucella suis
(S)-3-amino-4-(1H-imidazol-4-yl)-1-p-tolylbutan-2-one
-
 Brucella suis

Organism

Organism UniProt Comment Textmining
Brucella suis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant protein Brucella suis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-1-(4-(benzyloxy)phenyl)-4-(1H-imidazol-4-yl)butan-2-one
0.000006
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-1-(4-bromophenyl)-4-(1H-imidazol-4-yl)butan-2-one
0.000012
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-1-(4-chlorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
0.0000145
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-4-(1H-imidazol-4-yl)-1-(naphthalen-2-yl)butan-2-one
0.000015
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-1-(4-fluorophenyl)-4-(1H-imidazol-4-yl)butan-2-one
0.000015
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-4-(1H-imidazol-4-yl)-1-p-tolylbutan-2-one
0.000016
-
 pH 9.2, 30°C Brucella suis (S)-3-amino-4-(1H-imidazol-4-yl)-1-(4-phenoxyphenyl)butan-2-one
0.025
-
 pH 9.2, 30°C Brucella suis (2S)-2-amino-N'-(biphenyl-4-ylsulfonyl)-3-(1H-imidazol-4-yl)propanehydrazide
0.07
-
 pH 9.2, 30°C Brucella suis (2S)-2-amino-N'-[(4-bromophenyl)sulfonyl]-3-(1H-imidazol-4-yl)propanehydrazide
0.14
-
 pH 9.2, 30°C Brucella suis (2S)-2-amino-3-(1H-imidazol-4-yl)-N'-(naphthalen-2-ylsulfonyl)propanehydrazide
0.16
-
 pH 9.2, 30°C Brucella suis (2S)-2-amino-3-(1H-imidazol-4-yl)-N'-[(4-methylphenyl)sulfonyl]propanehydrazide