BRENDA - Enzyme Database show
show all sequences of 1.1.1.220

Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase

Steinerstauch, P.; Wermuth, B.; Leimbacher, W.; Curtius, H.C.; Biochem. Biophys. Res. Commun. 164, 1130-1136 (1989)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-pyruvoyltetrahydropterin + NADPH
Homo sapiens
involved in de novo biosynthesis of tetrahydrobiopterin
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
enzyme is identical to aldose reductase
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitrobenzaldehyde + NADPH
-
286310
Homo sapiens
4-nitrobenzylalcohol + NADP+
-
-
-
?
6-pyruvoyltetrahydropterin + NADPH
-
286310
Homo sapiens
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286310
Homo sapiens
?
6-pyruvoyltetrahydropterin + NADPH
involved in de novo biosynthesis of tetrahydrobiopterin
286310
Homo sapiens
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286310
Homo sapiens
?
additional information
typical substrates of aldose reductase tested as substrates
286310
Homo sapiens
?
-
-
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-pyruvoyltetrahydropterin + NADPH
Homo sapiens
involved in de novo biosynthesis of tetrahydrobiopterin
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
Homo sapiens
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitrobenzaldehyde + NADPH
-
286310
Homo sapiens
4-nitrobenzylalcohol + NADP+
-
-
-
?
6-pyruvoyltetrahydropterin + NADPH
-
286310
Homo sapiens
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286310
Homo sapiens
?
6-pyruvoyltetrahydropterin + NADPH
involved in de novo biosynthesis of tetrahydrobiopterin
286310
Homo sapiens
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286310
Homo sapiens
?
additional information
typical substrates of aldose reductase tested as substrates
286310
Homo sapiens
?
-
-
-
-
Other publictions for EC 1.1.1.220
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
286309
Milstien
The biosynthesis of tetrahydro ...
Rattus norvegicus
J. Biol. Chem.
264
8066-8073
1989
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286310
Steinerstauch
Human liver 6-pyruvoyl tetrahy ...
Homo sapiens
Biochem. Biophys. Res. Commun.
164
1130-1136
1989
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286308
Milstien
Biosynthesis of tetrahydrobiop ...
Bos taurus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
128
1099-1107
1985
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3
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3
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