BRENDA - Enzyme Database show
show all sequences of 1.1.1.220

Biosynthesis of tetrahydrobiopterin: conversion of dihydroneopterin triphosphate to tetrahydropterin intermediates

Milstien, S.; Kaufman, S.; Biochem. Biophys. Res. Commun. 128, 1099-1107 (1985)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-pyruvoyltetrahydropterin + NADPH
Rattus norvegicus
involved in de novo biosynthesis of tetrahydrobiopterin
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
Rattus norvegicus
?
6-pyruvoyltetrahydropterin + NADPH
Bos taurus
involved in de novo biosynthesis of tetrahydrobiopterin
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
Bos taurus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
bovine
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
from brain
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal medulla
-
Bos taurus
-
brain
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.0000159
-
-
Bos taurus
0.000021
-
liver
Rattus norvegicus
0.0000514
-
brain
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6-pyruvoyltetrahydropterin + NADPH
-
286308
Rattus norvegicus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Rattus norvegicus
?
6-pyruvoyltetrahydropterin + NADPH
-
286308
Bos taurus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Bos taurus
?
6-pyruvoyltetrahydropterin + NADPH
involved in de novo biosynthesis of tetrahydrobiopterin
286308
Rattus norvegicus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Rattus norvegicus
?
6-pyruvoyltetrahydropterin + NADPH
involved in de novo biosynthesis of tetrahydrobiopterin
286308
Bos taurus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Bos taurus
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6-pyruvoyltetrahydropterin + NADPH
Rattus norvegicus
involved in de novo biosynthesis of tetrahydrobiopterin
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
Rattus norvegicus
?
6-pyruvoyltetrahydropterin + NADPH
Bos taurus
involved in de novo biosynthesis of tetrahydrobiopterin
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
Bos taurus
?
Purification (Commentary) (protein specific)
Commentary
Organism
from brain
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal medulla
-
Bos taurus
-
brain
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
0.0000159
-
-
Bos taurus
0.000021
-
liver
Rattus norvegicus
0.0000514
-
brain
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6-pyruvoyltetrahydropterin + NADPH
-
286308
Rattus norvegicus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Rattus norvegicus
?
6-pyruvoyltetrahydropterin + NADPH
-
286308
Bos taurus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Bos taurus
?
6-pyruvoyltetrahydropterin + NADPH
involved in de novo biosynthesis of tetrahydrobiopterin
286308
Rattus norvegicus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Rattus norvegicus
?
6-pyruvoyltetrahydropterin + NADPH
involved in de novo biosynthesis of tetrahydrobiopterin
286308
Bos taurus
6-lactoyl-5,6,7,8-tetrahydropterin + NADP+
-
286308
Bos taurus
?
Other publictions for EC 1.1.1.220
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
286309
Milstien
The biosynthesis of tetrahydro ...
Rattus norvegicus
J. Biol. Chem.
264
8066-8073
1989
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2
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1
1
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2
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1
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2
2
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5
1
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1
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1
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2
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1
1
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1
-
2
2
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286310
Steinerstauch
Human liver 6-pyruvoyl tetrahy ...
Homo sapiens
Biochem. Biophys. Res. Commun.
164
1130-1136
1989
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1
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1
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1
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4
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1
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1
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4
-
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-
-
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-
-
-
286308
Milstien
Biosynthesis of tetrahydrobiop ...
Bos taurus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
128
1099-1107
1985
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2
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2
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1
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3
3
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4
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2
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1
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3
3
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4
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