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Literature summary for 1.1.1.22 extracted from

  • Cole, J.N.; Aziz, R.K.; Kuipers, K.; Timmer, A.M.; Nizet, V.; van Sorge, N.M.
    A conserved UDP-glucose dehydrogenase encoded outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus (2012), J. Bacteriol., 194, 6154-6161.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
x * 42000, SDS-PAGE, x * 43400, calculated Streptococcus pyogenes
43400
-
x * 42000, SDS-PAGE, x * 43400, calculated Streptococcus pyogenes

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes Q9A0Z5 isoform HasB2
-
Streptococcus pyogenes 5448 Q9A0Z5 isoform HasB2
-
Streptococcus pyogenes M1 GAS P0C0F5 isoform HasB
-
Streptococcus pyogenes M1 GAS 5448 P0C0F5 isoform HasB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
Streptococcus pyogenes UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?
UDP-alpha-D-glucose + 2 NAD+ + H2O
-
Streptococcus pyogenes 5448 UDP-alpha-D-glucuronate + 2 NADH + 2 H+
-
?

Subunits

Subunits Comment Organism
? x * 42000, SDS-PAGE, x * 43400, calculated Streptococcus pyogenes

Synonyms

Synonyms Comment Organism
HasB
-
Streptococcus pyogenes M1 GAS
HasB2
-
Streptococcus pyogenes

General Information

General Information Comment Organism
physiological function precise allelic exchange mutagenesis of isoform hasB in strain 5448, a representative of the globally disseminated M1T1 serotype, does not abolish hyaluronic acid capsule synthesis due to presence of paralog HasB2. Mutagenesis of HasB2 alone slightly decreases capsule abundance. A HasB HasB2 double mutant becomes completely acapsular Streptococcus pyogenes M1 GAS
physiological function precise allelic exchange mutagenesis of isoform hasB in strain 5448, a representative of the globally disseminated M1T1 serotype, does not abolish hyaluronic acid capsule synthesis due to presence of paralog HasB2. Mutagenesis of HasB2 alone slightly decreases capsule abundance. A HasB HasB2 double mutant becomes completely acapsular Streptococcus pyogenes