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Literature summary for 1.1.1.22 extracted from

  • Jiang, S.S.; Lin, T.Y.; Wang, W.B.; Liu, M.C.; Hsueh, P.R.; Liaw, S.J.
    Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence (2010), Antimicrob. Agents Chemother., 54, 2000-2009.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.22

Protein Variants

Protein Variants Comment Organism
additional information construction by Tn5 transposon mutagenesis of a knockout mutant of ugd, that is extremely sensitive to polymyxin B, presumably because of alterations in lipopolysaccharide structure and cell surface architecture in the mutant. The mutant is defective in swarming, expresses lower levels of virulence factor hemolysin, and has lower cell invasion ability. Complementation of the ugd or galU mutant with the full-length ugd gene leads to the restoration of wild-type phenotypic traits, phenotype, overview Proteus mirabilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + 2 NAD+ + H2O Proteus mirabilis
-
 UDP-glucuronic acid + 2 NADH + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Proteus mirabilis C3VI43 gene ugd
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 2 NAD+ + H2O
-
 Proteus mirabilis UDP-glucuronic acid + 2 NADH + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucose dehydrogenase
-
 Proteus mirabilis
Ugd
-
 Proteus mirabilis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Proteus mirabilis

Expression

Organism Comment Expression
Proteus mirabilis expression of Ugd is induced by polymyxin B through RppA, a putative response regulator of the bacterial two-component system up

General Information

General Information Comment Organism
additional information mutation in either ugd leads to activation of RpoE, an extracytoplasmic function sigma factor that is activated by protein misfolding and alterations in cell surface structure in other bacteria. Activation of RpoE or RpoE overexpression causes inhibition of FlhDC and hemolysin expression Proteus mirabilis