BRENDA - Enzyme Database show
show all sequences of 1.1.1.22

Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine

Reen, R.K.; Jamwal, D.S.; Taneja, S.C.; Koul, J.L.; Dubey, R.K.; Wiebel, F.J.; Singh, J.; Biochem. Pharmacol. 46, 229-238 (1993)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
piperine
stronger inhibition with intestinal cell enzyme than with rat liver enzyme
Cavia porcellus
piperine
non-competitive, reversible, non-pH-dependent, 90% inhibition at concentration 0.05 mM and 10% inhibition at concentration 0.01 mM
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.015
-
UDPglucose
pH 9.4
Rattus norvegicus
0.035
-
UDPglucose
pH 8.6
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UDPglucose + NAD+ + H2O
Cavia porcellus
-
UDPglucuronate + NADH
-
-
?
UDPglucose + NAD+ + H2O
Rattus norvegicus
-
UDPglucuronate + NADH
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cavia porcellus
-
-
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Cavia porcellus
-
liver
-
Rattus norvegicus
-
small intestine
-
Cavia porcellus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-OH-benzopyrene + NAD+
-
286303
Rattus norvegicus
?
-
-
-
?
UDP-glucose + 2 NAD+ + H2O
-
286303
Cavia porcellus
UDP-glucuronate + 2 NADH + 2 H+
-
-
-
?
UDP-glucose + 2 NAD+ + H2O
-
286303
Rattus norvegicus
UDP-glucuronate + 2 NADH + 2 H+
-
-
-
?
UDPglucose + NAD+ + H2O
-
286303
Cavia porcellus
UDPglucuronate + NADH
-
-
-
?
UDPglucose + NAD+ + H2O
-
286303
Rattus norvegicus
UDPglucuronate + NADH
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.6
-
two pH optima, pH 8.6 and pH 9.4
Rattus norvegicus
9.4
-
two pH optima, pH 8.6 and pH 9.4
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
piperine
stronger inhibition with intestinal cell enzyme than with rat liver enzyme
Cavia porcellus
piperine
non-competitive, reversible, non-pH-dependent, 90% inhibition at concentration 0.05 mM and 10% inhibition at concentration 0.01 mM
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.015
-
UDPglucose
pH 9.4
Rattus norvegicus
0.035
-
UDPglucose
pH 8.6
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
UDPglucose + NAD+ + H2O
Cavia porcellus
-
UDPglucuronate + NADH
-
-
?
UDPglucose + NAD+ + H2O
Rattus norvegicus
-
UDPglucuronate + NADH
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Cavia porcellus
-
liver
-
Rattus norvegicus
-
small intestine
-
Cavia porcellus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-OH-benzopyrene + NAD+
-
286303
Rattus norvegicus
?
-
-
-
?
UDP-glucose + 2 NAD+ + H2O
-
286303
Cavia porcellus
UDP-glucuronate + 2 NADH + 2 H+
-
-
-
?
UDP-glucose + 2 NAD+ + H2O
-
286303
Rattus norvegicus
UDP-glucuronate + 2 NADH + 2 H+
-
-
-
?
UDPglucose + NAD+ + H2O
-
286303
Cavia porcellus
UDPglucuronate + NADH
-
-
-
?
UDPglucose + NAD+ + H2O
-
286303
Rattus norvegicus
UDPglucuronate + NADH
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.6
-
two pH optima, pH 8.6 and pH 9.4
Rattus norvegicus
9.4
-
two pH optima, pH 8.6 and pH 9.4
Rattus norvegicus
Other publictions for EC 1.1.1.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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1
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3
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9364-9374
2012
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1
1
1
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-
4
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1
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1
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4
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1
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1
1
1
1
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-
4
-
-
-
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-
-
-
-
1
-
-
-
-
4
-
-
-
-
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-
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-
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725276
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194
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2012
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-
-
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-
2
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7
-
-
-
-
-
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2
1
-
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1
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2
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2
1
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2
2
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287
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2012
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1
1
5
-
-
4
-
-
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-
2
-
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-
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1
-
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2
-
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1
-
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1
1
1
5
-
-
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-
4
-
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-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
4
4
721871
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75
2049-2051
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1
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-
6
-
-
2
1
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4
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-
1
-
-
-
-
-
1
1
1
-
2
-
1
1
1
1
-
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1
1
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6
-
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2
1
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1
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-
1
1
1
-
2
-
1
1
1
-
-
-
-
-
-
-
724328
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9651-9663
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1
1
1
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1
-
-
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1
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-
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193
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1
1
3
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2
-
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5
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1
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2
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2
1
1
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1
3
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2
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1
-
1
2
-
2
1
1
-
-
-
-
-
-
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-
725729
Banerjee
-
UDP-glucose dehydrogenase from ...
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68
37-43
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-
-
-
-
-
-
5
2
-
-
2
-
-
1
-
-
1
-
-
1
1
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2
1
1
-
-
-
1
1
1
2
-
-
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-
2
-
-
-
-
5
-
2
-
-
2
-
-
-
-
1
-
1
1
-
2
1
1
-
-
-
1
1
1
-
-
-
-
-
-
-
726278
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6
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-
-
-
1
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2
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726412
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46
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2011
-
-
1
-
-
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2
-
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2
-
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2
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2
1
1
1
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1
1
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1
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2
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2
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2
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
710750
Rocha
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66
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-
-
1
1
-
-
-
-
-
-
1
2
-
8
-
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1
-
-
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2
1
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1
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1
1
1
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2
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2
1
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710762
Rocha
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Sphingomonas elodea, Sphingomonas elodea ATCC 31461
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66
69-72
2010
-
-
1
1
-
-
-
-
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2
-
4
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1
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2
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1
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1
1
1
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2
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1
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2
-
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-
-
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1
1
-
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710889
Jiang
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Proteus mirabilis
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54
2000-2009
2010
-
-
-
-
1
-
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1
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3
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1
1
1
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728319
Yurist-Doutsch
N-glycosylation in Archaea: on ...
Haloferax volcanii, Haloferax volcanii DSM 3757
Mol. Microbiol.
75
1047-1058
2010
-
-
-
-
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1
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2
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7
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8
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8
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2
2
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695880
Lee
Computational analysis of the ...
Homo sapiens
Arch. Biochem. Biophys.
486
35-43
2009
-
-
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1
8
-
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2
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8
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698005
Ariyakumar
Characterization of two host-s ...
Aliivibrio fischeri
FEMS Microbiol. Lett.
299
65-73
2009
-
-
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1
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7
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1
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1
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698331
Huang
UDP-glucose dehydrogenase as a ...
Homo sapiens
Int. J. Cancer
126
315-327
2009
-
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
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1
1
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1
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-
698529
Sheng
Use of induction promoters to ...
Streptococcus equi subsp. zooepidemicus, Streptococcus equi subsp. zooepidemicus FHA0
J. Appl. Microbiol.
107
136-144
2009
2
-
1
-
-
-
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2
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2
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1
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2
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700059
Loutet
Contributions of two UDP-gluco ...
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1
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1
1
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2
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2
1
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286303
Reen
Impairment of UDP-glucose dehy ...
Cavia porcellus, Rattus norvegicus
Biochem. Pharmacol.
46
229-238
1993
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-
-
-
-
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2
2
1
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2
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5
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1
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11
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5
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2
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2
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1
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1
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11
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5
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2
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286304
Grubb
Serum stimulation of UDP-gluco ...
Homo sapiens
Biochem. Mol. Biol. Int.
30
819-827
1993
1
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2
2
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286290
Jaenicke
Dissociation and in vitro reco ...
Bos taurus
Biochemistry
25
7283-7287
1986
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-
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-
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2
1
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2
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1
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1
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1
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2
1
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286292
Schiller
UDP-glucose dehydrogenase from ...
Escherichia coli
Biochim. Biophys. Acta
453
418-425
1976
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-
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1
1
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2
1
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286291
Druzhinina
Uridine diphosphate 2-deoxyglu ...
Bos taurus
Biochim. Biophys. Acta
381
301-307
1975
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-
-
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1
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3
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1
3
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286293
Schiller
Partial purification and prope ...
Escherichia coli
Biochim. Biophys. Acta
293
1-10
1973
3
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2
3
2
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1
1
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2
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1
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1
16
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1
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1
1
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1
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3
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1
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2
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3
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2
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1
1
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1
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1
16
-
1
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1
1
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286294
Davies
Properties of uridine diphosph ...
Lilium longiflorum
Arch. Biochem. Biophys.
152
53-61
1972
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-
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2
4
2
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1
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2
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4
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1
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1
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4
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2
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1
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1
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2
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2
4
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1
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1
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286295
Sivaswami
Uridine diphosphoglucose dehyd ...
Rattus norvegicus
Biochim. Biophys. Acta
276
43-52
1972
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-
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1
2
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1
2
1
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2
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1
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1
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1
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2
1
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1
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2
1
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2
1
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1
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286296
Molz
Uridine diphosphate glucose de ...
Rattus norvegicus
Biochim. Biophys. Acta
250
6-13
1971
1
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4
1
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2
1
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5
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1
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1
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1
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4
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1
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1
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1
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2
1
-
5
-
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1
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286297
Ankel
Biosynthesis of uridine diphos ...
Papiliotrema laurentii
Biochemistry
5
1864-1869
1966
1
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4
1
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1
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3
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1
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1
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11
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1
1
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1
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1
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1
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4
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1
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1
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1
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1
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11
-
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1
1
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286299
Neufeld
Inhibition of the UDP-D-glucos ...
Bos taurus, Gallus gallus, Pisum sativum
Biochem. Biophys. Res. Commun.
19
456-461
1965
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3
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3
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3
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2
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6
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3
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3
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2
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6
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286298
Goldberg
pH dependence of the reactions ...
Bos taurus
J. Biol. Chem.
238
3109-3114
1963
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1
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1
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1
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4
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4
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-
286300
Strominger
Enzymatic formation of uridine ...
Bos taurus
J. Biol. Chem.
224
79-90
1957
1
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1
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1
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1
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1
1
1
13
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1
1
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1
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1
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1
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1
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1
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1
1
1
13
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1
1
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