BRENDA - Enzyme Database show
show all sequences of 1.1.1.198

A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua

Polichuk, D.R.; Zhang, Y.; Reed, D.W.; Schmidt, J.F.; Covello, P.S.; Phytochemistry 71, 1264-1269 (2010)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.027
-
(-)-cis-carveol
pH 9.5, 30C
Artemisia annua
0.086
-
(-)-artemisia alcohol
pH 9.5, 30C
Artemisia annua
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Artemisia annua
E5DD06
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
trichome
high expression in glandular trichome
Artemisia annua
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
2.17
-
substrate (-)-borneol, pH 9.5, 30C
Artemisia annua
5.33
-
substrate (+)-borneol, pH 9.5, 30C
Artemisia annua
10.33
-
substrate (-)-trans-pinocarveol, pH 9.5, 30C
Artemisia annua
13.5
-
substrate (-)-trans-carveol, pH 9.5, 30C
Artemisia annua
35.7
-
substrate (-)-artemisia alcohol, pH 9.5, 30C
Artemisia annua
147.4
-
substrate (-)-cis-carveol, pH 9.5, 30C
Artemisia annua
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(+)-borneol + NAD+
-
726116
Artemisia annua
(+)-camphor + NADH + H+
-
-
-
?
(-)-artemisia alcohol + NAD+
-
726116
Artemisia annua
artemisia ketone + NADH + H+
-
-
-
?
(-)-borneol + NAD+
-
726116
Artemisia annua
(+)-camphor + NADH + H+
-
-
-
?
(-)-cis-carveol + NAD+
-
726116
Artemisia annua
(-)-carvone + NADH + H+
-
-
-
?
(-)-trans-carveol + NAD+
-
726116
Artemisia annua
(-)-carvone + NADH + H+
-
-
-
?
(-)-trans-pinocarveol + NAD+
-
726116
Artemisia annua
(-)-pinocarvone + NADH + H+
-
-
-
?
additional information
no substrates: citronellol, lavandulol, myrtenol, and (S)-(-)-perillyl alcohol, artemisinic alcohol, farnesol, khusinol, and santalol, secoisolariciresinol, larixol, phytol, retinol, benzyl alcohol, cinnamyl alcohol, 2-cyclohexen-1-ol, and 3-methyl-2-buten-1-ol
726116
Artemisia annua
?
-
-
-
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
10
-
-
Artemisia annua
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
no cofactor: NADP+
Artemisia annua
NAD+
-
Artemisia annua
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
no cofactor: NADP+
Artemisia annua
NAD+
-
Artemisia annua
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.027
-
(-)-cis-carveol
pH 9.5, 30C
Artemisia annua
0.086
-
(-)-artemisia alcohol
pH 9.5, 30C
Artemisia annua
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
trichome
high expression in glandular trichome
Artemisia annua
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
2.17
-
substrate (-)-borneol, pH 9.5, 30C
Artemisia annua
5.33
-
substrate (+)-borneol, pH 9.5, 30C
Artemisia annua
10.33
-
substrate (-)-trans-pinocarveol, pH 9.5, 30C
Artemisia annua
13.5
-
substrate (-)-trans-carveol, pH 9.5, 30C
Artemisia annua
35.7
-
substrate (-)-artemisia alcohol, pH 9.5, 30C
Artemisia annua
147.4
-
substrate (-)-cis-carveol, pH 9.5, 30C
Artemisia annua
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(+)-borneol + NAD+
-
726116
Artemisia annua
(+)-camphor + NADH + H+
-
-
-
?
(-)-artemisia alcohol + NAD+
-
726116
Artemisia annua
artemisia ketone + NADH + H+
-
-
-
?
(-)-borneol + NAD+
-
726116
Artemisia annua
(+)-camphor + NADH + H+
-
-
-
?
(-)-cis-carveol + NAD+
-
726116
Artemisia annua
(-)-carvone + NADH + H+
-
-
-
?
(-)-trans-carveol + NAD+
-
726116
Artemisia annua
(-)-carvone + NADH + H+
-
-
-
?
(-)-trans-pinocarveol + NAD+
-
726116
Artemisia annua
(-)-pinocarvone + NADH + H+
-
-
-
?
additional information
no substrates: citronellol, lavandulol, myrtenol, and (S)-(-)-perillyl alcohol, artemisinic alcohol, farnesol, khusinol, and santalol, secoisolariciresinol, larixol, phytol, retinol, benzyl alcohol, cinnamyl alcohol, 2-cyclohexen-1-ol, and 3-methyl-2-buten-1-ol
726116
Artemisia annua
?
-
-
-
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
10
-
-
Artemisia annua
Other publictions for EC 1.1.1.198
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724125
Sarker
Molecular cloning and function ...
Lavandula x intermedia
Arch. Biochem. Biophys.
528
163-170
2012
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
2
-
-
2
1
-
-
-
1
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
2
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
726116
Polichuk
A glandular trichome-specific ...
Artemisia annua
Phytochemistry
71
1264-1269
2010
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
1
6
-
7
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
6
-
7
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286162
Dehal
Metabolism of monoterpenes: Sp ...
Salvia officinalis
Arch. Biochem. Biophys.
258
287-291
1987
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286163
Croteau
Biosynthesis of monoterpenes. ...
Salvia officinalis
Arch. Biochem. Biophys.
188
182-193
1978
-
-
-
-
-
-
15
3
-
-
1
1
-
1
-
-
1
-
-
1
-
1
12
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
2
-
-
-
-
15
-
3
-
-
1
1
-
-
-
1
-
1
-
1
12
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-