BRENDA - Enzyme Database show
show all sequences of 1.1.1.197

Glutathione mixed disulfide inhibitors of the human placental NADP-linked 15-hydroxyprostaglandin dehydrogenase

Chung, H.; Fried, J.; Williams-Ashman, E.; Jarabak, J.; Prostaglandins 33, 383-390 (1987)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
beta-mercaptoacetate
-
Homo sapiens
beta-mercaptolactate
-
Homo sapiens
beta-Mercaptopyruvate
-
Homo sapiens
GSSG
-
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
human
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
beta-mercaptoacetate
-
Homo sapiens
beta-mercaptolactate
-
Homo sapiens
beta-Mercaptopyruvate
-
Homo sapiens
GSSG
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
placenta
-
Homo sapiens
-
Other publictions for EC 1.1.1.197
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
348015
Fujimori
Expression of NADP(+)-Dependen ...
Macaca fascicularis
J. Biochem.
131
383-389
2002
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
5
-
4
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
5
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347836
Krook
Three-dimensional model of NAD ...
Homo sapiens
FEBS Lett.
322
139-142
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
348018
Krook
Carboxyethyllysine in a protei ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
90
502-506
1993
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347835
Wermuth
NADP-dependent 15-hydroxyprost ...
Homo sapiens
Prostaglandins
44
5-9
1992
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347833
Chung
Glutathione mixed disulfide in ...
Homo sapiens
Prostaglandins
33
383-390
1987
-
-
-
-
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347834
Chung
Polycyclic aromatic hydrocarbo ...
Homo sapiens
J. Biol. Chem.
262
12448-12451
1987
-
-
-
-
-
-
2
10
-
-
-
-
-
1
-
-
1
-
-
1
1
-
13
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
10
-
-
-
-
-
-
-
1
-
1
1
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347832
Tai
Purification of NADP+/NADPH-de ...
Sus scrofa
Methods Enzymol.
86
142-147
1982
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347831
Chang
Prostaglandin-9-ketoreductase ...
Homo sapiens, Sus scrofa
Biochem. Biophys. Res. Commun.
99
745-751
1981
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
3
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347830
Levasseur
Prostaglandin metabolism in th ...
Homo sapiens, Platyrrhini, Rattus norvegicus
Biochem. Biophys. Res. Commun.
95
236-242
1980
-
-
-
-
-
-
1
1
-
-
-
-
-
3
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
5
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347829
Jarabak
Comparison of substrate specif ...
Homo sapiens
Prostaglandins
18
241-246
1979
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347827
Westbrook
NADP-linked 15-hydroxyprostagl ...
Homo sapiens
Biochem. Biophys. Res. Commun.
76
943-949
1977
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347828
Wong
Detection of 15-hydroxyprostag ...
Bos taurus
Biochim. Biophys. Acta
500
436-439
1977
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-