BRENDA - Enzyme Database show
show all sequences of 1.1.1.19

Vitamin C. Biosynthesis, recycling and degradation in mammals

Linster, C.L.; Van Schaftingen, E.; FEBS J. 274, 1-22 (2007)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
sorbinil
-
Homo sapiens
sorbinil
-
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.33
-
D-glucuronate
-
Homo sapiens
0.69
-
D-glucuronolactone
-
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum membrane
-
Homo sapiens
5789
-
endoplasmic reticulum membrane
-
Rattus norvegicus
5789
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-glucuronate + NADPH
Homo sapiens
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Rattus norvegicus
a step in ascorbic acid biosynthesis, overview
L-gulonate + NADP+
-
-
r
D-glucuronolactone + NADPH
Homo sapiens
-
L-gulonolactone + NADP+
-
-
r
D-glucuronolactone + NADPH
Rattus norvegicus
-
L-gulonolactone + NADP+
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-glucuronate + NADPH
-
686647
Homo sapiens
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
686647
Rattus norvegicus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
a step in ascorbic acid biosynthesis, overview
686647
Rattus norvegicus
L-gulonate + NADP+
-
-
-
r
D-glucuronolactone + NADPH
-
686647
Homo sapiens
L-gulonolactone + NADP+
-
-
-
r
D-glucuronolactone + NADPH
-
686647
Rattus norvegicus
L-gulonolactone + NADP+
-
-
-
r
Subunits
Subunits
Commentary
Organism
monomer
-
Homo sapiens
monomer
-
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
NADP+
dependent on
Homo sapiens
NADP+
dependent on
Rattus norvegicus
NADPH
dependent on
Homo sapiens
NADPH
dependent on
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADP+
dependent on
Homo sapiens
NADP+
dependent on
Rattus norvegicus
NADPH
dependent on
Homo sapiens
NADPH
dependent on
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
sorbinil
-
Homo sapiens
sorbinil
-
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.33
-
D-glucuronate
-
Homo sapiens
0.69
-
D-glucuronolactone
-
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum membrane
-
Homo sapiens
5789
-
endoplasmic reticulum membrane
-
Rattus norvegicus
5789
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-glucuronate + NADPH
Homo sapiens
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Rattus norvegicus
a step in ascorbic acid biosynthesis, overview
L-gulonate + NADP+
-
-
r
D-glucuronolactone + NADPH
Homo sapiens
-
L-gulonolactone + NADP+
-
-
r
D-glucuronolactone + NADPH
Rattus norvegicus
-
L-gulonolactone + NADP+
-
-
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-glucuronate + NADPH
-
686647
Homo sapiens
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
686647
Rattus norvegicus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
a step in ascorbic acid biosynthesis, overview
686647
Rattus norvegicus
L-gulonate + NADP+
-
-
-
r
D-glucuronolactone + NADPH
-
686647
Homo sapiens
L-gulonolactone + NADP+
-
-
-
r
D-glucuronolactone + NADPH
-
686647
Rattus norvegicus
L-gulonolactone + NADP+
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
-
Homo sapiens
monomer
-
Rattus norvegicus
Other publictions for EC 1.1.1.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
711916
Sahoo
Synthesis and biological evalu ...
Rattus norvegicus
Eur. J. Med. Chem.
45
909-914
2010
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
686647
Linster
Vitamin C. Biosynthesis, recyc ...
Homo sapiens, Rattus norvegicus
FEBS J.
274
1-22
2007
-
-
-
-
-
-
2
2
2
-
-
4
-
2
-
-
-
-
-
2
-
-
5
2
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
-
-
-
2
-
2
2
-
-
4
-
-
-
-
-
2
-
-
5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667168
Barski
Developmental expression and f ...
Homo sapiens, Mus musculus
Am. J. Physiol. Renal Physiol.
289
F200-F207
2005
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286150
Shinoda
Inhibition of human aldehyde r ...
Homo sapiens
Biol. Pharm. Bull.
22
741-744
1999
-
-
-
-
-
-
5
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286146
Goode
Accumulation of xylitol in the ...
Bos taurus, Homo sapiens, Rattus norvegicus
FEBS Lett.
395
174-178
1996
-
-
-
-
-
-
6
2
-
-
4
6
-
6
-
-
2
-
-
3
2
-
6
2
2
-
-
-
2
-
2
6
-
-
-
-
-
-
6
-
-
-
-
6
-
2
-
-
4
6
-
-
-
2
-
3
2
-
6
2
2
-
-
-
2
-
2
-
-
-
-
-
-
-
286148
Sato
Human kidney aldose and aldehy ...
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
J. Diabetes Complicat.
7
179-187
1993
-
-
-
-
-
-
9
6
-
-
2
4
-
3
-
-
1
-
-
3
1
-
6
1
-
-
-
-
-
-
-
6
-
-
-
-
-
-
6
-
-
-
-
9
-
6
-
-
2
4
-
-
-
1
-
3
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286147
Kaufman
An overview of gamma-hydroxybu ...
Homo sapiens, Mesocricetus auratus, Rattus norvegicus
Neurochem. Res.
16
965-974
1991
-
-
-
-
-
-
16
3
-
-
-
5
-
3
-
-
1
-
-
7
-
-
6
-
-
-
-
-
4
3
-
6
-
-
-
-
-
-
6
-
-
-
-
16
-
3
-
-
-
5
-
-
-
1
-
7
-
-
6
-
-
-
-
-
4
3
-
-
-
-
-
-
-
-
286149
Bhatnagar
Human liver aldehyde reductase ...
Homo sapiens
Arch. Biochem. Biophys.
287
329-336
1991
-
-
-
-
-
-
3
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
1
1
1
1
2
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
286145
Poulsom
Inhibition of hexonate dehydro ...
Bos taurus
Biochem. Pharmacol.
35
2955-2959
1986
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286139
Flynn
Aldehyde reductase (L-hexonate ...
Sus scrofa
Methods Enzymol.
89
501-506
1982
-
-
-
-
-
-
9
7
-
-
2
-
-
1
-
-
1
-
-
1
1
-
6
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
9
-
7
-
-
2
-
-
-
-
1
-
1
1
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286142
Kaufman
Kinetics of coupled gamma-hydr ...
Mesocricetus auratus
J. Biol. Chem.
256
6890-6894
1981
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286143
Tulsiani
Resolution and partial charact ...
Mus musculus
J. Biol. Chem.
252
2545-2550
1977
-
-
-
-
-
-
6
13
-
-
2
1
-
2
-
-
1
-
-
1
1
-
5
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
13
-
-
2
1
-
-
-
1
-
1
1
-
5
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
286140
Bublitz
-
Ascorbic acid synthesis in ani ...
Sus scrofa
Methods Enzymol.
6
334-337
1963
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
1
-
-
1
1
1
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
1
1
1
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
286141
York
TPN-L-gulonate dehydrogenase ...
Sus scrofa
Biochim. Biophys. Acta
47
298-306
1961
-
-
-
-
-
2
1
2
-
-
-
-
2
1
-
-
1
-
-
1
-
1
3
-
-
-
2
-
1
-
1
2
-
-
-
-
-
-
2
-
-
2
-
1
-
2
-
-
-
-
2
-
-
1
-
1
-
1
3
-
-
-
2
-
1
-
1
-
-
-
-
-
-
-
286144
Sivak
Enzymes of meso-inositol catab ...
Schwanniomyces occidentalis
Biochim. Biophys. Acta
53
426-428
1961
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
-
-
-
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-
-
2
-
-
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-
2
-
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-
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