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Literature summary for 1.1.1.19 extracted from
- Human kidney aldose and aldehyde reductases (1993), J. Diabetes Complicat., 7, 179-187.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Al 1576 | - |
Canis lupus familiaris |  |
| Al 1576 | - |
Homo sapiens | |
| Al 1576 | - |
Rattus norvegicus | |
| ponalrestat | - |
Canis lupus familiaris | |
| ponalrestat | - |
Homo sapiens | |
| ponalrestat | - |
Rattus norvegicus | |
| Tolrestat | - |
Canis lupus familiaris | |
| Tolrestat | - |
Homo sapiens | |
| Tolrestat | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.6 | - |
D-glucuronate | - |
Canis lupus familiaris | |
| 2.1 | - |
L-gulonate | - |
Canis lupus familiaris | |
| 3.1 | - |
D-glucuronate | - |
Homo sapiens | |
| 4.8 | - |
L-gulonate | - |
Homo sapiens | |
| 6.2 | - |
D-glucuronate | - |
Rattus norvegicus | |
| 7.6 | - |
L-gulonate | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
gel filtration | Homo sapiens |
| 39000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Rattus norvegicus | - |
L-gulonate + NADP+ | - |
r | |
| L-gulonate + NADP+ | Homo sapiens | - |
D-glucuronate + NADPH | - |
r | |
| L-gulonate + NADP+ | Rattus norvegicus | - |
D-glucuronate + NADPH | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Canis lupus familiaris | - |
| kidney | cortex | Homo sapiens | - |
| kidney | cortex | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1.339 | - |
highly purified enzyme, substrate NADPH | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-aldose + NADPH | - |
Rattus norvegicus | L-alditol + NADP+ | - |
r | |
| D-aldose + NADPH | i.e. D-xylose, D-glucose, D-galactose are reduced with 100fold less active than D-glucuronate | Homo sapiens | L-alditol + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Rattus norvegicus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH + H+ | - |
Canis lupus familiaris | L-gulonate + NADP+ | - |
r | |
| L-gulonate + NADP+ | - |
Homo sapiens | D-glucuronate + NADPH | - |
r | |
| L-gulonate + NADP+ | - |
Rattus norvegicus | D-glucuronate + NADPH | - |
r | |
| L-gulonate + NADP+ | - |
Canis lupus familiaris | D-glucuronate + NADPH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 39000, SDS-PAGE | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Homo sapiens | |
| NADP+ | - |
Rattus norvegicus | |
| NADP+ | - |
Canis lupus familiaris | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
| NADPH | - |
Canis lupus familiaris | |
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Release 2023.1 (January 2023)
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