BRENDA - Enzyme Database show
show all sequences of 1.1.1.19

Aldehyde reductase (L-hexonate: NADP dehydrogenase) from pig kidney

Flynn, T.G.; Cromlish, J.A.; Davidson, W.S.; Methods Enzymol. 89, 501-506 (1982)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2,3-Butanedione
-
Sus scrofa
diethyldicarbonate
-
Sus scrofa
hydroxylamine
-
Sus scrofa
iodoacetic acid
-
Sus scrofa
NaF
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Phenobarbital
-
Sus scrofa
Phenylglyoxal
-
Sus scrofa
pyridoxal 5'-phosphate
-
Sus scrofa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.009
-
NADPH
-
Sus scrofa
0.02
-
NADP+
uncoupled reaction
Sus scrofa
0.35
-
4-Nitrobenzaldehyde
-
Sus scrofa
2.6
-
Pyridine-3-aldehyde
-
Sus scrofa
4.8
-
D-glyceraldehyde
-
Sus scrofa
7.3
-
L-gulonate
-
Sus scrofa
8.4
-
D-glucuronate
-
Sus scrofa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
33000
-
SDS-PAGE, gel filtration
Sus scrofa
36700
-
1 * 36700, SDS-PAGE
Sus scrofa
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
-
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
5.45
-
-
Sus scrofa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitrobenzaldehyde + NADPH
-
286139
Sus scrofa
4-nitrobenzyl alcohol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286139
Sus scrofa
glycerol + NADP+
-
-
-
r
L-gulonate + NADP+
-
286139
Sus scrofa
D-glucuronate + NADPH
-
-
-
-
additional information
broad specificity
286139
Sus scrofa
?
-
-
-
-
additional information
reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde
286139
Sus scrofa
?
-
-
-
-
pyridine-3-aldehyde + NADPH
-
286139
Sus scrofa
3-hydroxypyridine + NADP+
-
-
-
r
Subunits
Subunits
Commentary
Organism
monomer
1 * 36700, SDS-PAGE
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde
Sus scrofa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde
Sus scrofa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,3-Butanedione
-
Sus scrofa
diethyldicarbonate
-
Sus scrofa
hydroxylamine
-
Sus scrofa
iodoacetic acid
-
Sus scrofa
NaF
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Phenobarbital
-
Sus scrofa
Phenylglyoxal
-
Sus scrofa
pyridoxal 5'-phosphate
-
Sus scrofa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.009
-
NADPH
-
Sus scrofa
0.02
-
NADP+
uncoupled reaction
Sus scrofa
0.35
-
4-Nitrobenzaldehyde
-
Sus scrofa
2.6
-
Pyridine-3-aldehyde
-
Sus scrofa
4.8
-
D-glyceraldehyde
-
Sus scrofa
7.3
-
L-gulonate
-
Sus scrofa
8.4
-
D-glucuronate
-
Sus scrofa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
33000
-
SDS-PAGE, gel filtration
Sus scrofa
36700
-
1 * 36700, SDS-PAGE
Sus scrofa
Purification (Commentary) (protein specific)
Commentary
Organism
-
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
5.45
-
-
Sus scrofa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-nitrobenzaldehyde + NADPH
-
286139
Sus scrofa
4-nitrobenzyl alcohol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286139
Sus scrofa
glycerol + NADP+
-
-
-
r
L-gulonate + NADP+
-
286139
Sus scrofa
D-glucuronate + NADPH
-
-
-
-
additional information
broad specificity
286139
Sus scrofa
?
-
-
-
-
additional information
reduction of D-glyceraldehyde: pro-4R hydrogen is transferred from NADPH, i.e. A-specific, attacks re face of carbonyl group of the D-glyceraldehyde
286139
Sus scrofa
?
-
-
-
-
pyridine-3-aldehyde + NADPH
-
286139
Sus scrofa
3-hydroxypyridine + NADP+
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 36700, SDS-PAGE
Sus scrofa
Other publictions for EC 1.1.1.19
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
711916
Sahoo
Synthesis and biological evalu ...
Rattus norvegicus
Eur. J. Med. Chem.
45
909-914
2010
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-
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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-
-
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-
-
-
-
686647
Linster
Vitamin C. Biosynthesis, recyc ...
Homo sapiens, Rattus norvegicus
FEBS J.
274
1-22
2007
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-
-
-
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-
2
2
2
-
-
4
-
2
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-
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-
2
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-
5
2
-
-
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4
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-
4
-
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-
2
-
2
2
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4
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2
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5
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667168
Barski
Developmental expression and f ...
Homo sapiens, Mus musculus
Am. J. Physiol. Renal Physiol.
289
F200-F207
2005
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
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-
-
4
-
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2
-
-
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-
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-
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-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286150
Shinoda
Inhibition of human aldehyde r ...
Homo sapiens
Biol. Pharm. Bull.
22
741-744
1999
-
-
-
-
-
-
5
-
-
-
-
2
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
5
-
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-
-
-
2
-
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-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286146
Goode
Accumulation of xylitol in the ...
Bos taurus, Homo sapiens, Rattus norvegicus
FEBS Lett.
395
174-178
1996
-
-
-
-
-
-
6
2
-
-
4
6
-
6
-
-
2
-
-
3
2
-
6
2
2
-
-
-
2
-
2
6
-
-
-
-
-
-
6
-
-
-
-
6
-
2
-
-
4
6
-
-
-
2
-
3
2
-
6
2
2
-
-
-
2
-
2
-
-
-
-
-
-
-
286148
Sato
Human kidney aldose and aldehy ...
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
J. Diabetes Complicat.
7
179-187
1993
-
-
-
-
-
-
9
6
-
-
2
4
-
3
-
-
1
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-
3
1
-
6
1
-
-
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-
-
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-
6
-
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-
6
-
-
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-
9
-
6
-
-
2
4
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1
-
3
1
-
6
1
-
-
-
-
-
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-
-
-
-
-
-
-
286147
Kaufman
An overview of gamma-hydroxybu ...
Homo sapiens, Mesocricetus auratus, Rattus norvegicus
Neurochem. Res.
16
965-974
1991
-
-
-
-
-
-
16
3
-
-
-
5
-
3
-
-
1
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-
7
-
-
6
-
-
-
-
-
4
3
-
6
-
-
-
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-
-
6
-
-
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-
16
-
3
-
-
-
5
-
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-
1
-
7
-
-
6
-
-
-
-
-
4
3
-
-
-
-
-
-
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286149
Bhatnagar
Human liver aldehyde reductase ...
Homo sapiens
Arch. Biochem. Biophys.
287
329-336
1991
-
-
-
-
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-
3
-
-
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-
2
-
1
-
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1
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2
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1
1
1
1
2
-
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2
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3
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2
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1
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2
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1
1
1
1
-
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-
-
-
-
-
286145
Poulsom
Inhibition of hexonate dehydro ...
Bos taurus
Biochem. Pharmacol.
35
2955-2959
1986
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-
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3
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2
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1
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3
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1
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286139
Flynn
Aldehyde reductase (L-hexonate ...
Sus scrofa
Methods Enzymol.
89
501-506
1982
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-
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-
9
7
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-
2
-
-
1
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1
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1
1
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6
1
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1
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1
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9
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7
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2
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1
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1
1
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6
1
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286142
Kaufman
Kinetics of coupled gamma-hydr ...
Mesocricetus auratus
J. Biol. Chem.
256
6890-6894
1981
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2
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1
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286143
Tulsiani
Resolution and partial charact ...
Mus musculus
J. Biol. Chem.
252
2545-2550
1977
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6
13
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2
1
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2
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1
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1
1
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5
1
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2
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6
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13
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2
1
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1
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1
1
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5
1
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2
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286140
Bublitz
-
Ascorbic acid synthesis in ani ...
Sus scrofa
Methods Enzymol.
6
334-337
1963
-
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1
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1
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1
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1
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1
1
1
3
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1
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1
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1
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1
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1
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1
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1
1
1
3
-
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1
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286141
York
TPN-L-gulonate dehydrogenase ...
Sus scrofa
Biochim. Biophys. Acta
47
298-306
1961
-
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2
1
2
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-
-
2
1
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1
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1
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1
3
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2
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1
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1
2
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1
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1
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1
3
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2
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1
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1
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286144
Sivak
Enzymes of meso-inositol catab ...
Schwanniomyces occidentalis
Biochim. Biophys. Acta
53
426-428
1961
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