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Literature summary for 1.1.1.189 extracted from

  • Kankofer, M.; Wiercinski, J.
    Prostaglandin E2 9-keto reductase from bovine term placenta (1999), Prostaglandins Leukot. Essent. Fatty Acids, 61, 29-32.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
17beta-estradiol equimolar to substrate inhibits 80% of enzyme activity Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.006
-
9,10-phenanthrenequinone
-
Bos taurus
0.022
-
20alpha-hydroxy-pregn-4-en-3-one
-
Bos taurus
0.117
-
prostaglandin E2
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Bos taurus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ Bos taurus can influence the processes of luteolysis and can be involved in parturition and retention of fetal membranes (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Bos taurus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ can influence the processes of luteolysis and can be involved in parturition and retention of fetal membranes Bos taurus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?
20alpha-hydroxy-pregn-4-en-3-one + NADP+
-
Bos taurus progesterone + NADPH
-
?
9,10-phenanthrenequinone + NADPH
-
Bos taurus ?
-
?

Subunits

Subunits Comment Organism
monomer alpha, 1 * 45000, SDS-PAGE Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Bos taurus
NADPH
-
Bos taurus