Literature summary for 1.1.1.188 extracted from

Yoda, T.; Kikuchi, K.; Miki, Y.; Onodera, Y.; Hata, S.; Takagi, K.; Nakamura, Y.; Hirakawa, H.; Ishida, T.; Suzuki, T.; Ohuchi, N.; Sasano, H.; McNamara, K.M.
11beta-Prostaglandin F2alpha, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancer (2015), Mol. Cell. Endocrinol., 413, 236-247.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene AKR1C3, expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+	Homo sapiens	-	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+	-	?
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+	Homo sapiens	-	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	-	-
Homo sapiens	P42330	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	of invasive ductal carcinoma of the breast, immunohistochemical analysis	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MDA-MB-231 cell	high expression level	Homo sapiens	-
MDA-MB-453 cell	-	Homo sapiens	-
additional information	AKR1B1 shows decreased expression in neoplastic disease, with decreased AKR1B1 immunoreactivity in carcinoma cells compared with nonneoplastic ductal cells, suggesting that AKR1B1 activity might be suppressed in tumor cells in breast cancer tissues	Homo sapiens	-
SK-BR-3 cell	-	Homo sapiens	-
SUM-185PE cell	high expression level	Homo sapiens	-
T-47D cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+	-	Homo sapiens	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+	-	?
(5Z,13E)-(15S)-9alpha,11beta,15-trihydroxyprosta-5,13-dienoate + NADP+	-	Homo sapiens	(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
17beta-hydroxysteroid dehydrogenase type 5	-	Homo sapiens
17betaHSD5	-	Homo sapiens
AKR1B1	-	Homo sapiens
AKR1C3	-	Homo sapiens
More	cf. 1.1.1.21	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	AKR1B1 shows decreased expression in neoplastic disease, AKR1B1 activity might be suppressed in tumor cells in breast cancer tissues	down

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the aldo-keto reductase family 1	Homo sapiens
malfunction	administration of an AKR1C3 inhibitor significantly decreases 11beta-PGF2alpha concentrations in culture media of breast cancer cells	Homo sapiens
metabolism	AKR1C3 is an enzyme responsible for the metabolism of steroid hormones such as androgens, progesterones and estrogens in addition to the reduction of PGD2 to 11beta-PGF2alpha	Homo sapiens
physiological function	in breast cancer, the status of the 11alpha-PGF2alpha and 11beta-PGF2alpha cognate FP receptor is associated with adverse clinical outcome only in the AKR1C3 positive cases, immunohistochemical analysis. FP receptor-mediated functions of 11beta-PGF2alpha using FP receptor expressed MCF-7 cell line shows that 11beta-PGF2alpha treatment phosphorylates ERK and CREB and induces Slug expression through FP receptor in MCF-FP, and MCF-FP cells demonstrate decreased chemosensitivity compared to parental controls. The actions of AKR1C3, but not of AKR1B1, can produce FP receptor ligands whose activation results in carcinoma cell survival in breast cancer. 11beta-PGF2alpha stimulates phosphorylation of ERK and CREB via FP receptor. AKR1C3-dependent signaling performs through 11beta-PGF2alpha and the FP receptor, overview	Homo sapiens
physiological function	in breast cancer, the status of the 11alpha-PGF2alpha and 11beta-PGF2alpha cognate FP receptor is associated with adverse clinical outcome only in the AKR1C3 positive cases, while there are no significant correlations between FP receptor status and any of the clinicathological parameters in AKR1B1 positive cases. AKR1B1 does not induce Slug expression	Homo sapiens

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Release 2023.1 (January 2023)