Literature summary for 1.1.1.188 extracted from

Lee, E.S.; Rasmussen, C.A.; Filla, M.S.; Slauson, S.R.; Kolb, A.W.; Peters, D.M.; Kaufman, P.L.; Gabelt, B.T.; Brandt, C.R.
Prospects for lentiviral vector mediated prostaglandin F synthase gene delivery in monkey eyes in vivo (2014), Curr. Eye Res., 39, 859-870.

Search for more literature for 1.1.1.188

Application

Application	Comment	Organism
medicine	lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene resultes in long-term reduction of intraocular pressure and may eliminate off-target tissue effects and the need for daily topical PGF2alpha self-administration	Bos taurus

Cloned(Commentary)

Cloned (Comment)	Organism
expression of myc-tagged GFP-PGFS in non-human primate eyes via FIV vector leading to a significant reduction of intraocular pressure, IOP, the GFP-tag can still be detected after 48-52 weeks, the decrease in IOP lasted for 5 months, method evaluation	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
additional information	lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene to the eye. Expression of myc-tagged GFP-PGFS in non-human primate eyes via FIV vector leads to a significant reduction of intraocular pressure, IOP, the GFP-tag can still be detected after 48-52 weeks, the decrease in IOP lasts for 5 months. The IOP decrease is not as much as seen with topical prostaglandin therapy in monkey eyes, method evaluation. In human eye a single injection of lentiviral vectors into either the anterior or posterior chambers can induce a transient uveitis. Following transcorneal injection of vector into the living monkey eyes, biomicroscopic examination initially reveal cells and flare in the anterior chamber and some corneal haze that is largely resolved by 3 weeks post injection. This is not due to bacterial endotoxin contamination of the vector preparations and is likely the result of activation of innate viral sensors in the eye	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
PGFS	-	Bos taurus
prostaglandin F synthase	-	Bos taurus

General Information

General Information	Comment	Organism
physiological function	lentiviral vector-mediated delivery of the prostaglandin F synthase (PGFS) gene resultes in long-term reduction of intraocular pressure and may eliminate off-target tissue effects and the need for daily topical PGF2alpha self-administration	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)