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Literature summary for 1.1.1.188 extracted from

  • Gram, A.; Buechler, U.; Boos, A.; Hoffmann, B.; Kowalewski, M.P.
    Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2?-synthase (PGFS, AKR1C3) and 15-hydroxyprostaglandin dehydrogenase (HPGD) (2013), Biol. Reprod., 89, 2-2.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PGFS, quantitative expression analysis, recombinant expression of His-tagged canine-specific PGFS (AKR1C3) in Escherichia coli Canis lupus familiaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin H2 + NADP+ Canis lupus familiaris
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prostaglandin F2alpha + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris Q5FYA7
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged canine-specific PGFS (AKR1C3) from Escherichia coli Canis lupus familiaris

Source Tissue

Source Tissue Comment Organism Textmining
additional information quantitative enzyme expression analysis during pregnancy and prepartum Canis lupus familiaris
-
trophoblast
-
Canis lupus familiaris
-
uterus utero/placental expression of PGFS (AKR1C3) is identified in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation. Colocalization of 15-hydroxyprostaglandin dehydrogenase (HPGD) with PGFS (AKR1C3) expression. Uterine PGFS (AKR1C3) is up-regulated postimplantation and declined prepartum Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity towards prostaglandin E2 synthesis Canis lupus familiaris ?
-
?
prostaglandin H2 + NADP+
-
Canis lupus familiaris prostaglandin F2alpha + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
AKR1C3
-
Canis lupus familiaris
PGF2alpha-synthase
-
Canis lupus familiaris
PGFS
-
Canis lupus familiaris
prostaglandin F synthase UniProt Canis lupus familiaris
prostaglandin F2alpha-synthase
-
Canis lupus familiaris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Canis lupus familiaris

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Canis lupus familiaris

General Information

General Information Comment Organism
metabolism availability of prostaglandins can be regulated by changes in 15-hydroxyprostaglandin dehydrogenase, HPGD, an enzyme that catabolizes prostaglandin E2 and prostaglandin F2alpha to their inactive metabolites 13,14-dihydro-15keto-PGF2alpha and 13,14-dihydro-15-keto prostaglandin E2 (PGEM) Canis lupus familiaris
physiological function the utero/placental expression of PGFS (AKR1C3) is identified in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation, suggesting a possible role for PGFS (AKR1C3) in the trophoblast invasion Canis lupus familiaris