BRENDA - Enzyme Database show
show all sequences of 1.1.1.188

Prostaglandin F synthase

Watanabe, K.; Prostaglandins 68-69, 401-407 (2002)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
GSH
dependent on
Ovis aries
additional information
4fold activation by heat treatment
Ovis aries
Engineering
Amino acid exchange
Commentary
Organism
Y55F
complete elimination of PGD2, and PQ reductase activities, 27fold stimulation of PGH2 reductase activity
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
9,10-phenanthrenequinone
competitive inhibition of the PGD2 11-ketoreductase activity, not of PGH2 9-,11-endoperoxide reductase activity
Rattus norvegicus
additional information
no inhibition by 9,10-phenanthrenequinone
Trypanosoma brucei
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Trypanosoma brucei
5829
-
membrane
associated
Ovis aries
16020
-
microsome
-
Ovis aries
-
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
16000
-
1 * 16000
Ovis aries
17000
-
-
Ovis aries
33000
-
-
Trypanosoma brucei
36666
-
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
36670
-
lung enzyme, sequence calculation
Rattus norvegicus
37000
-
lung and liver isozymes
Bos taurus
37000
-
lung isozyme
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
prostaglandin D2 + NADPH + H+
Homo sapiens
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin D2 + NADPH + H+
Rattus norvegicus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin D2 + NADPH + H+
Bos taurus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin D2 + NADPH + H+
Oryctolagus cuniculus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin H2 + NADPH
Homo sapiens
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Rattus norvegicus
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Bos taurus
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Oryctolagus cuniculus
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Ovis aries
-
prostaglandin F2alpha + NADP+
-
-
?
prostaglandin H2 + NADPH
Trypanosoma brucei
-
prostaglandin F2alpha + NADP+
-
-
?
prostaglandin H2 + NADPH
Bos taurus
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
prostaglandin F2alpha + NADP+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
to isozymes in lung and liver
-
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-
Ovis aries
-
-
-
Rattus norvegicus
-
two isozymes in lung and liver
-
Trypanosoma brucei
-
-
-
Purification (Commentary)
Commentary
Organism
enzyme from lung, to homogeneity
Rattus norvegicus
Reaction
Reaction
Commentary
Organism
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
Tyr55 is critical for the reaction, the reactions with different substrates might follow different mechanisms
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Bos taurus
-
liver
liver-type isozyme
Oryctolagus cuniculus
-
liver
-
Rattus norvegicus
-
lung
; PGH2 9-,11-endoperoxide reductase activity lung-type isozyme
Bos taurus
-
lung
lung-type isozyme
Homo sapiens
-
lung
-
Rattus norvegicus
-
seminal vesicle
-
Ovis aries
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Homo sapiens
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Rattus norvegicus
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Bos taurus
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Oryctolagus cuniculus
?
-
-
-
?
additional information
enzyme does not reduce prostaglandins D2 and E2
657211
Trypanosoma brucei
?
-
-
-
-
additional information
enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase
657211
Ovis aries
?
-
-
-
-
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin H2 + NADPH
-
657211
Homo sapiens
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Rattus norvegicus
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Bos taurus
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Oryctolagus cuniculus
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Ovis aries
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
no stereochemic determination/identification of the product
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Homo sapiens
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Rattus norvegicus
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Bos taurus
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NADP+
-
-
-
?
Subunits
Subunits
Commentary
Organism
monomer
1 * 16000
Ovis aries
monomer
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
dependent on
Bos taurus
NADPH
dependent on
Oryctolagus cuniculus
NADPH
dependent on
Ovis aries
NADPH
dependent on
Rattus norvegicus
NADPH
dependent on
Trypanosoma brucei
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
GSH
dependent on
Ovis aries
additional information
4fold activation by heat treatment
Ovis aries
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
dependent on
Bos taurus
NADPH
dependent on
Oryctolagus cuniculus
NADPH
dependent on
Ovis aries
NADPH
dependent on
Rattus norvegicus
NADPH
dependent on
Trypanosoma brucei
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
Y55F
complete elimination of PGD2, and PQ reductase activities, 27fold stimulation of PGH2 reductase activity
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
9,10-phenanthrenequinone
competitive inhibition of the PGD2 11-ketoreductase activity, not of PGH2 9-,11-endoperoxide reductase activity
Rattus norvegicus
additional information
no inhibition by 9,10-phenanthrenequinone
Trypanosoma brucei
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Bos taurus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Oryctolagus cuniculus
5829
-
cytosol
-
Rattus norvegicus
5829
-
cytosol
-
Trypanosoma brucei
5829
-
membrane
associated
Ovis aries
16020
-
microsome
-
Ovis aries
-
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
16000
-
1 * 16000
Ovis aries
17000
-
-
Ovis aries
33000
-
-
Trypanosoma brucei
36666
-
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
36670
-
lung enzyme, sequence calculation
Rattus norvegicus
37000
-
lung and liver isozymes
Bos taurus
37000
-
lung isozyme
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
prostaglandin D2 + NADPH + H+
Homo sapiens
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin D2 + NADPH + H+
Rattus norvegicus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin D2 + NADPH + H+
Bos taurus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin D2 + NADPH + H+
Oryctolagus cuniculus
-
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
?
prostaglandin H2 + NADPH
Homo sapiens
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Rattus norvegicus
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Bos taurus
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Oryctolagus cuniculus
-
prostaglandin D2 + NADP+
-
-
?
prostaglandin H2 + NADPH
Ovis aries
-
prostaglandin F2alpha + NADP+
-
-
?
prostaglandin H2 + NADPH
Trypanosoma brucei
-
prostaglandin F2alpha + NADP+
-
-
?
prostaglandin H2 + NADPH
Bos taurus
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
prostaglandin F2alpha + NADP+
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
enzyme from lung, to homogeneity
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Bos taurus
-
liver
liver-type isozyme
Oryctolagus cuniculus
-
liver
-
Rattus norvegicus
-
lung
; PGH2 9-,11-endoperoxide reductase activity lung-type isozyme
Bos taurus
-
lung
lung-type isozyme
Homo sapiens
-
lung
-
Rattus norvegicus
-
seminal vesicle
-
Ovis aries
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Homo sapiens
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Rattus norvegicus
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Bos taurus
?
-
-
-
?
9,10-phenanthrenequinone + NADPH
i.e. PQ
657211
Oryctolagus cuniculus
?
-
-
-
?
additional information
enzyme does not reduce prostaglandins D2 and E2
657211
Trypanosoma brucei
?
-
-
-
-
additional information
enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase
657211
Ovis aries
?
-
-
-
-
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Homo sapiens
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Rattus norvegicus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Bos taurus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin D2 + NADPH + H+
-
657211
Oryctolagus cuniculus
prostaglandin 9alpha,11beta-F2 + NADP+
i.e. 11-epi PGF2alpha
-
-
?
prostaglandin H2 + NADPH
-
657211
Homo sapiens
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Rattus norvegicus
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Bos taurus
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Oryctolagus cuniculus
prostaglandin D2 + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Ovis aries
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
-
657211
Trypanosoma brucei
prostaglandin F2alpha + NADP+
no stereochemic determination/identification of the product
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Homo sapiens
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Rattus norvegicus
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Bos taurus
prostaglandin F2alpha + NADP+
-
-
-
?
prostaglandin H2 + NADPH
enzyme also shows PGH2 9-,11-endoperoxide reductase activity
657211
Oryctolagus cuniculus
prostaglandin F2alpha + NADP+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
monomer
1 * 16000
Ovis aries
monomer
1 * 36666, lung enzyme, sequence calculation
Rattus norvegicus
Other publictions for EC 1.1.1.188
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
724504
Gram
Biosynthesis and degradation o ...
Canis lupus familiaris
Biol. Reprod.
89
002
2013
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4
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1
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1
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725674
Liedtke
Development of potent and sele ...
Homo sapiens
J. Med. Chem.
56
2429-2446
2013
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3
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726469
Siemieniuch
Prostaglandin endoperoxide syn ...
Felis catus
Reprod. Domest. Anim.
48
72-78
2013
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655139
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Prostaglandin F synthase ...
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Detection and regulation of th ...
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cDNA cloning, expression and c ...
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Watanabe
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Watanabe
Structural similarity of bovin ...
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Goh
Content and formation of prost ...
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Watanabe
Enzymatic formation of prostag ...
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Wong
Purification of PGD2 11-ketore ...
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1982
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Wong
Purification and partial chara ...
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Reingold
A novel prostaglandin 11-keto ...
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Watanabe
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