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Literature summary for 1.1.1.185 extracted from

  • Prieto, J.G.; Sarmiento, R.M.; Burgos, J.
    Kinetics of alpha-dicarbonyls reduction by L-glycol dehydrogenase from hen muscle (1983), Arch. Biochem. Biophys., 224, 372-377.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetone pI 7.2 form Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0022
-
NADPH with 2,3-pentanedione Gallus gallus
0.0024
-
NADPH with glyoxal Gallus gallus
0.0028
-
NADPH with methylglyoxal Gallus gallus
0.0031
-
NADPH with diacetyl Gallus gallus
0.035
-
2,3-Pentanedione
-
Gallus gallus
0.09
-
methylglyoxal pI 7.2 form Gallus gallus
0.12
-
diacetyl pI 7.2 form Gallus gallus
0.41
-
Glyoxal pI 7.2 form Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
hen
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus gallus

Reaction

Reaction Comment Organism Reaction ID
an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+ glyoxal reduction by enzyme form pI 7.2 follows ordered bi-bi mechanism in which the coenzyme is the first substrate to bind to the enzyme Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,3-pentanedione + NADH
-
Gallus gallus L-acetylethylcarbinol + NAD+
-
?
diacetyl + NADH
-
Gallus gallus L-acetoin + NAD+
-
?
glyoxal + NADPH + H+
-
Gallus gallus ?
-
r
methylglyoxal + NADH
-
Gallus gallus L-lactaldehyde
-
?
R1-CO-CO-R2 + NAD(P)H methylglyoxal, diacetyl, 2,3-pentanedione Gallus gallus R1-CO-CHOH-R2 + NAD(P)+
-
?
R1-CO-CO-R2 + NAD(P)H vicinal dicarbonyl: e.g. glyoxal Gallus gallus R1-CO-CHOH-R2 + NAD(P)+
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Gallus gallus
NADPH
-
Gallus gallus