Application | Comment | Organism |
---|---|---|
medicine | antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion in liver. Menadione and 18beta-glycyrrhetinic acid are inhibitory | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
18beta-glycyrrhetinic acid | inhibits the reduction of bupropion in liver microsomes | Homo sapiens | |
menadione | inhibits the reduction of bupropion in liver cytosol | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bupropion + NADPH + H+ | - |
Homo sapiens | erythrohydrobupropion + NADP+ | in liver cytosol, antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion | ? | |
bupropion + NADPH + H+ | - |
Homo sapiens | threohydrobupropion + NADP+ | in liver cytosol, antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion | ? |