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Literature summary for 1.1.1.184 extracted from

  • Ema, T.; Yagasaki, H.; Okita, N.; Takeda, M.; Sakai, T.
    Asymmetric reduction of ketones using recombinant E. coli cells that produce a versatile carbonyl reductase with high enantioselectivity and broad substrate specificity (2006), Tetrahedron, 62, 6143-6149.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
gene Gre2, high level expression in Escherichia coli strain BL21(DE3) Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
gene Gre2 or YOL151w
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,2-dimethylcyclohexanone-1,3-dione + NADPH + H+
-
Saccharomyces cerevisiae (S)-3-hydroxy-2,2-dimethylcyclohexanone + NADP+
-
?
2,4-octanedione + NADPH + H+
-
Saccharomyces cerevisiae (S)-2-hydroxy-4-octanone + NADP+
-
?
alpha-acetoxyacetophenone + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?
carnitine + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?
dihydrokawain + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?
ethyl pyruvate + NADPH + H+
-
Saccharomyces cerevisiae ethyl 2-hydroxypropanoic acid + NADP+
-
?
ethyl pyruvate + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?
fluoxetine + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?
additional information high enantioselectivity and broad substrate specificity, overview Saccharomyces cerevisiae ?
-
?
pyrenophorin + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?
xestospongin A + NADPH + H+
-
Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
SCR
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Saccharomyces cerevisiae