BRENDA - Enzyme Database show
show all sequences of 1.1.1.184

Further characterization of chinese hamster carbonyl reductases (CHCRs)

Terada, T.; Sugihara, Y.; Nakamura, K.; Mizobuchi, H.; Maeda, M.; Chem. Biol. Interact. 143-144, 373-381 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of isozymes CHCR1-3 as His-tagged proteins in Escherichia coli strain BL21(DE3)
Cricetulus griseus
Inhibitors
Inhibitors
Commentary
Organism
Structure
Acetylsalicylate
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
cibacron
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
Ethacrynic acid
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
indomethacin
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
megestrol acetate
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
methyltestosterone
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
Norethindrone
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
pyrazole
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
pyruvate
inactivation of isozyme CHCR2, not of isozymes CHCR1 and 3
Cricetulus griseus
quercitrin
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
warfarin
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
31000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
32000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
34000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cricetulus griseus
-
3 isozymes CHCR1-3
-
Purification (Commentary)
Commentary
Organism
recombinant His-tagged isozymes CHCR1-3 from Escherichia coli strain BL21(DE3)
Cricetulus griseus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
strong expression of isozyme CHCR1, weaker expression of isozyme CHCR2, no expression of isozyme CHCR3
Cricetulus griseus
-
kidney
strong expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3
Cricetulus griseus
-
liver
moderate expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3
Cricetulus griseus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-benzoylpyridine + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
(S)-alpha-phenyl-4-pyridylmethanol + NADP+
-
-
-
ir
4-pregnen-3,20-dione + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5alpha-androstan-17beta-ol-3-one + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5alpha-androstane-3,17-dione + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5alpha-androstane-3alpha,17beta-diol + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
r
5beta-androstane-3,17-dione + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5beta-pregnan-3beta-ol-20-one + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
r
daunorubicin + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
DELTA4-androstan-17beta-ol-3-one + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
r
isatin + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
additional information
substrate specificities of the 3 isozymes, overview, no activity with 5alpha-androstan-3beta-ol-17-one
655213
Cricetulus griseus
?
-
-
-
-
prostaglandin A1 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin A2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin B2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin D2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin E2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin F2alpha + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
Subunits
Subunits
Commentary
Organism
?
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Cricetulus griseus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
-
assay at
Cricetulus griseus
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Cricetulus griseus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of isozymes CHCR1-3 as His-tagged proteins in Escherichia coli strain BL21(DE3)
Cricetulus griseus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Cricetulus griseus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Acetylsalicylate
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
cibacron
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
Ethacrynic acid
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
indomethacin
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
megestrol acetate
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
methyltestosterone
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
Norethindrone
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
pyrazole
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
pyruvate
inactivation of isozyme CHCR2, not of isozymes CHCR1 and 3
Cricetulus griseus
quercitrin
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
warfarin
IC50 for the 3 isozymes CHCR1-3, overview
Cricetulus griseus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
31000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
32000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
34000
-
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His-tagged isozymes CHCR1-3 from Escherichia coli strain BL21(DE3)
Cricetulus griseus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
strong expression of isozyme CHCR1, weaker expression of isozyme CHCR2, no expression of isozyme CHCR3
Cricetulus griseus
-
kidney
strong expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3
Cricetulus griseus
-
liver
moderate expression of all 3 isozyme in descending order CHCR1, CHCR2, CHCR3
Cricetulus griseus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4-benzoylpyridine + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
(S)-alpha-phenyl-4-pyridylmethanol + NADP+
-
-
-
ir
4-pregnen-3,20-dione + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5alpha-androstan-17beta-ol-3-one + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5alpha-androstane-3,17-dione + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5alpha-androstane-3alpha,17beta-diol + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
r
5beta-androstane-3,17-dione + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
5beta-pregnan-3beta-ol-20-one + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
r
daunorubicin + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
DELTA4-androstan-17beta-ol-3-one + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
r
isatin + NADPH
isozymes CHCR1-3
655213
Cricetulus griseus
?
-
-
-
ir
additional information
substrate specificities of the 3 isozymes, overview, no activity with 5alpha-androstan-3beta-ol-17-one
655213
Cricetulus griseus
?
-
-
-
-
prostaglandin A1 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin A2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin B2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin D2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin E2 + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
prostaglandin F2alpha + NADPH
isozymes CHCR1 and 2, no activity with isozyme CHCR3
655213
Cricetulus griseus
?
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 31000, isozyme CHCR1, SDS-PAGE, x * 32000, isozyme CHCR2, SDS-PAGE, x * 34000, isozyme CHCR3, SDS-PAGE
Cricetulus griseus
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Cricetulus griseus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.5
-
assay at
Cricetulus griseus
Other publictions for EC 1.1.1.184
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735405
Hou
Crystallographic analysis of a ...
Thermotoga maritima, Thermotoga maritima DSM 3109
Acta Crystallogr. Sect. F
71
847-855
2015
-
-
1
1
-
-
-
-
-
-
2
-
-
5
-
-
-
-
-
-
-
-
2
1
1
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
721912
Ma
Characterization of an aldo-ke ...
Thermotoga maritima, Thermotoga maritima DSM 3109
Biotechnol. Lett.
35
757-762
2013
1
1
1
-
-
-
3
3
-
1
1
-
5
5
-
-
1
-
-
-
1
-
17
1
1
1
2
3
1
-
-
3
-
-
-
1
1
1
3
-
-
-
-
3
-
3
-
1
1
-
5
-
-
1
-
-
1
-
17
1
1
1
2
3
1
-
-
-
-
2
2
-
-
-
724575
Gao
Production of (3S)-acetoin fro ...
Gluconobacter oxydans, Gluconobacter oxydans DSM 2003
Biores. Technol.
137
111-115
2013
-
1
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724718
Hartmanova
S-nitrosoglutathione covalentl ...
Homo sapiens
Chem. Biol. Interact.
202
136-145
2013
-
-
-
-
-
-
1
14
-
-
-
-
-
2
-
-
-
-
-
-
-
-
7
-
-
-
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
14
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
14
-
-
-
-
-
-
-
-
14
14
726512
Li
-
Highly enantioselective double ...
Komagataella pastoris, Komagataella pastoris GS115
Tetrahedron
69
3561-3564
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
7
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
721234
Suwa
Expression, purification, crys ...
Candida magnoliae, Candida magnoliae AKU4643
Acta Crystallogr. Sect. F
68
540-542
2012
-
1
1
1
-
-
-
-
-
-
-
2
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
724831
Tang
Carbonyl reduction of mequindo ...
Gallus gallus, Sus scrofa
Drug Metab. Dispos.
40
788-795
2012
-
1
2
-
2
-
-
6
4
-
4
-
-
5
-
-
-
-
-
2
-
-
6
2
-
-
-
6
-
-
-
-
-
-
-
-
1
2
-
-
2
-
-
-
-
6
4
-
4
-
-
-
-
-
-
2
-
-
6
2
-
-
-
6
-
-
-
-
-
-
-
-
6
6
726540
Molnari
Carbonyl reduction of bupropio ...
Homo sapiens
Xenobiotica
42
550-561
2012
-
1
-
-
-
-
2
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
722137
Richter
Biochemical characterisation o ...
Neurospora crassa, Neurospora crassa DSM 894
Enzyme Microb. Technol.
48
472-479
2011
-
-
1
-
-
-
-
-
-
-
3
-
-
4
-
-
1
-
-
-
4
3
27
1
3
1
-
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
4
3
27
1
3
1
-
-
1
-
-
-
-
1
1
-
-
-
724049
Ni
Biocatalytic properties of a r ...
Bacillus sp., Bacillus sp. ECU0013
Appl. Microbiol. Biotechnol.
89
1111-1118
2011
-
-
-
-
-
-
-
-
-
6
-
-
-
2
-
-
-
-
-
-
-
-
13
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
13
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
724714
Staab
Studies on reduction of S-nitr ...
Homo sapiens
Chem. Biol. Interact.
191
95-103
2011
-
-
1
-
4
-
1
7
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
7
-
-
-
1
1
-
-
-
-
2
1
-
4
-
-
1
1
7
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
7
-
-
-
-
-
-
-
-
7
7
724046
Schweiger
Characterization of two aldo-k ...
Gluconobacter oxydans, Gluconobacter oxydans 621H
Appl. Microbiol. Biotechnol.
87
1415-1426
2010
-
-
1
-
-
-
1
6
2
-
2
-
-
6
-
-
-
-
-
-
17
-
29
1
1
-
-
4
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
6
2
-
4
-
-
-
-
-
-
-
17
-
29
2
2
-
-
4
2
-
-
-
-
-
-
-
4
4
725727
Li
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Purification and characterizat ...
Pichia kudriavzevii, Pichia kudriavzevii SW 2026
J. Mol. Catal. B
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2010
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-
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-
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-
13
1
-
-
2
-
-
2
-
-
-
-
-
-
1
-
13
1
1
1
-
-
1
1
1
1
-
-
-
-
-
-
1
-
-
-
-
13
-
1
-
-
2
-
-
-
-
-
-
-
1
-
13
1
1
1
-
-
1
1
1
-
-
-
-
-
-
-
695711
Zhang
Improved production of (R)-1-p ...
Candida parapsilosis, Candida parapsilosis CCTCC M203011
Appl. Biochem. Biotechnol.
160
868-878
2009
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1
1
-
1
-
-
-
-
-
-
-
-
4
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695766
Zhang
Ser67Asp and His68Asp substitu ...
Candida parapsilosis, Candida parapsilosis CCTCC M203011
Appl. Environ. Microbiol.
75
2176-2183
2009
-
1
1
-
6
-
-
14
-
-
1
-
-
5
-
-
1
-
-
-
-
-
4
1
-
-
-
14
-
-
-
1
-
-
-
-
1
1
1
-
6
-
-
-
-
14
-
-
1
-
-
-
-
1
-
-
-
-
4
1
-
-
-
14
-
-
-
-
-
-
-
-
-
-
696788
Kansal
Enhancing the biocatalytic pot ...
Candida viswanathii, Candida viswanathii MTCC 5158
Biores. Technol.
100
1041-1047
2009
3
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
696909
Ye
A novel carbonyl reductase fro ...
Scheffersomyces stipitis
Biotechnol. Lett.
31
537-542
2009
-
1
1
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697262
Miura
Chinese hamster monomeric carb ...
Cricetulus griseus
Chem. Biol. Interact.
178
110-116
2009
-
-
1
-
-
-
1
14
-
-
8
-
-
4
-
-
1
-
-
8
-
-
11
1
-
-
-
9
-
-
-
1
-
-
2
-
-
3
3
-
-
-
3
3
-
14
-
-
8
-
-
-
-
3
-
13
-
-
11
3
-
-
-
9
-
-
-
-
-
-
-
-
-
-
697269
Miura
Investigation of the role of t ...
Cricetulus griseus, Homo sapiens, Rattus norvegicus
Chem. Biol. Interact.
178
211-214
2009
-
-
3
-
3
-
-
11
-
-
-
-
-
8
-
-
3
-
-
1
-
-
18
3
-
-
-
10
-
-
-
3
-
-
-
-
-
3
3
-
3
-
-
-
-
11
-
-
-
-
-
-
-
3
-
1
-
-
18
3
-
-
-
10
-
-
-
-
-
-
-
-
-
-
697272
El-Hawari
Analysis of the substrate-bind ...
Homo sapiens
Chem. Biol. Interact.
178
234-241
2009
-
-
1
-
3
-
-
15
1
-
-
-
-
2
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
15
2
-
-
-
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697584
Bains
Two nonsynonymous single nucle ...
Homo sapiens
Drug Metab. Dispos.
37
1107-1114
2009
-
1
1
-
-
-
-
8
-
-
1
-
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
9
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
8
-
-
1
-
-
-
-
1
-
-
-
-
4
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
697589
Gonzalez-Covarrubias
Pharmacogenetics of human carb ...
Homo sapiens
Drug Metab. Dispos.
37
400-407
2009
-
-
-
-
-
-
-
-
1
-
1
-
-
3
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711440
Zimmermann
Discovery of a potent and sele ...
Homo sapiens
Bioorg. Med. Chem.
17
530-536
2009
-
-
1
-
-
-
6
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
7
-
7
-
-
1
-
-
-
-
7
6
7
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711492
Ye
A new member of the short-chai ...
Scheffersomyces stipitis
Biores. Technol.
100
6022-6027
2009
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1
-
-
1
3
-
-
-
1
-
3
1
-
-
1
-
-
-
1
-
11
1
1
1
1
-
1
1
1
1
-
-
-
-
-
1
1
-
-
1
-
3
-
-
-
-
1
-
3
-
-
1
-
-
1
-
11
1
1
1
1
-
1
1
1
-
-
-
-
-
-
-
684196
Zhang
Crystallization and preliminar ...
Candida parapsilosis
Acta Crystallogr. Sect. F
64
252-254
2008
-
-
1
1
7
-
-
10
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
1
-
-
4
10
-
-
-
3
-
-
-
-
-
1
3
1
7
-
-
-
-
10
-
-
-
-
-
-
-
1
-
-
-
-
2
1
-
-
4
10
-
-
-
-
-
-
-
-
-
-
685640
Bhattacharyya
Production of carbonyl reducta ...
Geotrichum candidum, Geotrichum candidum NCIM
Biores. Technol.
99
8765-8770
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686056
Carlquist
Flavonoids as inhibitors of hu ...
Homo sapiens
Chem. Biol. Interact.
174
98-108
2008
-
-
1
1
-
-
8
1
-
-
-
-
-
3
-
-
1
-
-
-
2
-
6
-
-
-
-
-
-
-
-
-
-
-
8
-
-
1
-
1
-
-
8
8
-
1
-
-
-
-
-
-
-
1
-
-
2
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688169
Soni
Optimization of process parame ...
Candida viswanathii
J. Ind. Microbiol. Biotechnol.
35
167-173
2008
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1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688959
Miura
Different functions between hu ...
Homo sapiens
Mol. Cell. Biochem.
315
113-121
2008
-
-
1
-
-
-
-
4
1
-
1
-
-
2
-
-
-
-
-
5
-
-
3
1
-
-
-
3
1
2
-
4
-
-
-
-
-
1
4
-
-
-
-
-
-
4
1
-
1
-
-
-
-
-
-
5
-
-
3
1
-
-
-
3
1
2
-
-
-
-
-
-
-
-
689309
Zhu
Inverting the enantioselectivi ...
Sporidiobolus salmonicolor
Org. Lett.
10
525-528
2008
-
-
-
1
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
23
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
23
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690091
Tanaka
Molecular basis for peroxisoma ...
Sus scrofa
Structure
16
388-397
2008
-
-
1
1
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
1
-
2
-
-
-
-
-
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697582
Kassner
Carbonyl reductase 1 is a pred ...
Homo sapiens
Drug Metab. Dispos.
36
2113-2120
2008
-
1
1
-
-
-
1
8
1
-
-
-
-
2
-
-
1
-
-
8
-
-
4
-
-
-
-
1
-
-
-
1
1
-
1
-
1
1
1
-
-
-
1
1
1
8
1
-
-
-
-
-
-
1
-
8
-
-
4
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
700598
Gonzalez-Covarrubias
Inhibition of polymorphic huma ...
Homo sapiens
Pharm. Res.
25
1730-1734
2008
-
1
1
-
-
-
3
-
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-
-
-
-
2
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
4
-
12
-
1
1
1
-
-
-
12
3
4
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701097
Zhang
Crystal structure of a carbony ...
Candida parapsilosis, Candida parapsilosis CCTCC M203011
Protein Sci.
17
1412-1423
2008
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-
1
1
7
-
-
10
-
-
3
-
-
6
-
-
1
-
-
-
-
-
2
2
-
-
-
10
-
-
-
1
-
-
-
-
-
1
1
1
7
-
-
-
-
10
-
-
3
-
-
-
-
1
-
-
-
-
2
2
-
-
-
10
-
-
-
-
-
-
-
-
-
-
685454
Endo
Characterization of an oligome ...
Canis lupus familiaris
Biol. Pharm. Bull.
30
1787-1791
2007
-
-
1
-
-
-
10
22
1
-
2
-
-
4
-
-
-
-
-
2
-
-
20
1
-
-
-
22
-
-
-
-
-
-
10
-
-
1
-
-
-
-
10
10
-
22
1
-
2
-
-
-
-
-
-
2
-
-
20
1
-
-
-
22
-
-
-
-
-
-
-
-
-
-
686356
Gonzalez-Covarrubias
A functional genetic polymorph ...
Homo sapiens
Drug Metab. Dispos.
35
973-980
2007
-
-
1
-
1
-
-
8
-
-
1
-
-
2
-
-
-
-
-
1
-
-
3
1
-
-
-
8
-
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
8
-
-
1
-
-
-
-
-
-
1
-
-
3
1
-
-
-
8
-
-
-
-
-
-
-
-
-
-
687870
Hoffmann
Understanding oligomerization ...
Comamonas testosteroni
J. Biotechnol.
129
131-139
2007
-
-
-
1
1
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-
-
-
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-
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1
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688022
Imamura
Inhibition of carbonyl reducta ...
Sus scrofa
J. Enzyme Inhib. Med. Chem.
22
105-109
2007
-
-
-
-
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5
5
1
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1
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
5
1
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689311
Zhu
Asymmetric reduction of beta-k ...
Candida magnoliae
Org. Lett.
9
2561-2563
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667076
Aoki
Crystallization and preliminar ...
Sus scrofa
Acta Crystallogr. Sect. F
62
1037-1040
2006
-
-
1
1
-
-
-
-
1
-
1
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-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
1
1
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
667427
Maser
Neuroprotective role for carbo ...
Drosophila melanogaster, Homo sapiens
Biochem. Biophys. Res. Commun.
340
1019-1022
2006
1
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1
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1
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-
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6
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2
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1
-
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11
-
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-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
1
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669975
Zhu
Stereoselective enzymatic synt ...
Candida magnoliae
J. Org. Chem.
71
4202-4205
2006
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669976
Zhu
Enantioselective enzymatic red ...
Sporidiobolus salmonicolor
J. Org. Chem.
71
9484-9486
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
1
1
-
-
-
-
5
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
670264
Maser
11beta-Hydroxysteroid dehydrog ...
Homo sapiens
Mol. Cell. Endocrinol.
248
34-37
2006
-
-
-
-
-
-
1
1
2
-
2
3
-
1
-
-
1
-
-
2
-
-
5
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
1
2
-
2
3
-
-
-
1
-
2
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670459
Zhu
Stereoselective ketone reducti ...
Sporidiobolus salmonicolor
Org. Biomol. Chem.
4
2690-2695
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
-
6
-
12
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
12
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670927
Ema
-
Asymmetric reduction of ketone ...
Saccharomyces cerevisiae
Tetrahedron
62
6143-6149
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655067
Kizaki
Purification and characterizat ...
Rhodotorula glutinis
Biosci. Biotechnol. Biochem.
69
79-86
2005
-
1
-
-
-
-
11
-
-
3
2
-
-
3
-
-
1
-
-
-
1
-
36
1
1
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
11
-
-
-
3
2
-
-
-
-
1
-
-
1
-
36
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667891
Imamura
Differential pharmacokinetics ...
Rattus norvegicus
Biol. Pharm. Bull.
28
185-187
2005
-
-
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
668014
Morikawa
Highly active mutants of carbo ...
Candida magnoliae, Candida magnoliae AKU4643
Biosci. Biotechnol. Biochem.
69
544-552
2005
-
-
1
-
3
-
-
7
-
-
-
-
-
3
-
-
1
-
-
-
3
-
4
-
1
-
-
3
1
-
-
2
-
-
-
-
-
1
2
-
3
-
-
-
-
7
-
-
-
-
-
-
-
1
-
-
3
-
4
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
668135
Takenaka
Carbonyl reductase expression ...
Homo sapiens
Cancer Epidemiol. Biomarkers Prev.
14
1972-1975
2005
-
1
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668177
Slupe
Reduction of 13-deoxydoxorubic ...
Homo sapiens
Cardiovasc. Toxicol.
5
365-376
2005
-
-
1
-
-
-
1
1
-
-
-
5
-
1
-
-
1
1
-
1
-
-
11
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
1
-
-
-
5
-
-
-
1
-
1
-
-
11
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
668238
Oginuma
Involvement of carbonyl reduct ...
Sus scrofa
Chem. Biol. Interact.
155
148-154
2005
-
-
-
-
-
-
2
3
1
-
-
3
-
1
-
-
-
-
-
1
-
-
5
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
3
1
-
-
3
-
-
-
-
-
1
-
-
5
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
668391
Lakhman
Functional significance of a n ...
Homo sapiens
Drug Metab. Dispos.
33
254-257
2005
-
-
1
-
1
-
-
4
-
-
-
-
-
4
-
-
-
-
-
-
1
-
1
1
1
-
-
4
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
-
1
1
1
-
-
4
1
-
-
-
-
-
-
-
-
-
669865
Kamitori
X-ray structures of NADPH-depe ...
Sporidiobolus salmonicolor
J. Mol. Biol.
352
551-558
2005
-
-
1
1
-
-
-
-
-
-
-
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3
-
-
1
1
-
-
-
-
3
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654129
Teartasin
Expression, purification and p ...
Streptomyces coelicolor
Acta Crystallogr. Sect. D
D60
1137-1138
2004
-
-
1
1
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
654729
Doorn
Human carbonyl reductase catal ...
Homo sapiens
Biochemistry
43
13106-13114
2004
-
-
1
-
-
-
2
3
-
-
-
-
-
1
-
-
1
-
-
1
-
-
4
-
1
-
-
3
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
2
-
3
-
-
-
-
-
-
-
1
-
1
-
-
4
-
1
-
-
3
1
-
-
-
-
-
-
-
-
-
656548
Sgraja
Structural insights into the n ...
Drosophila melanogaster
J. Mol. Biol.
342
1613-1624
2004
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-
1
1
-
-
-
-
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-
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3
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-
1
1
-
-
-
-
5
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655040
Saratani
Purification and properties of ...
Cylindrocarpon sclerotigenum
Biosci. Biotechnol. Biochem.
67
1417-1420
2003
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1
-
-
-
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9
-
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2
-
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2
-
-
1
-
-
-
1
-
7
1
1
-
-
-
1
-
-
2
-
-
-
-
1
-
2
-
-
-
-
9
-
-
-
-
2
-
-
-
-
1
-
-
1
-
7
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
655212
Usami
Cloning, expression and tissue ...
Sus scrofa
Chem. Biol. Interact.
143-144
353-361
2003
-
-
1
-
-
-
4
19
-
-
2
-
-
1
-
-
1
-
-
5
1
-
22
1
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
4
-
19
-
-
2
-
-
-
-
1
-
5
1
-
22
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
655213
Terada
Further characterization of ch ...
Cricetulus griseus
Chem. Biol. Interact.
143-144
373-381
2003
-
-
1
-
-
-
11
-
-
-
3
-
-
3
-
-
1
-
-
3
-
-
17
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
11
-
-
-
-
3
-
-
-
-
1
-
3
-
-
17
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
656385
Imamura
Inactivation of rabbit liver c ...
Oryctolagus cuniculus
J. Enzyme Inhib. Med. Chem.
18
35-39
2003
-
-
-
-
-
-
3
4
1
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-
-
-
1
-
-
-
1
-
2
-
-
6
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
4
1
-
-
-
-
-
-
-
-
2
-
-
6
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
656568
Shimada
-
Stereoselective reduction of 4 ...
Sus scrofa
J. Mol. Catal. B
23
29-35
2003
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1
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15
1
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1
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-
-
-
-
1
-
-
16
1
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
15
1
-
-
-
-
-
-
-
-
1
-
-
16
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
655017
Yamamoto
Purification and properties of ...
Kluyveromyces lactis
Biosci. Biotechnol. Biochem.
66
1775-1778
2002
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1
-
-
-
-
12
-
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2
1
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2
-
-
1
-
-
-
1
-
7
1
1
-
1
-
1
1
-
2
-
-
-
-
1
-
2
-
-
-
-
12
-
-
-
-
2
1
-
-
-
1
-
-
1
-
7
1
1
-
1
-
1
1
-
-
-
-
-
-
-
-
655090
Cha
-
Stereochemical control in dias ...
Kluyveromyces marxianus
Biotechnol. Lett.
24
1695-1698
2002
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-
-
-
-
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1
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1
-
-
-
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-
11
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
11
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
347760
Ghosh
Porcine carbonyl reductase: st ...
Sus scrofa
J. Biol. Chem.
276
18457-18463
2001
-
-
-
-
-
-
-
-
-
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1
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-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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347767
Imamura
Inhibitory effects of flavonoi ...
Oryctolagus cuniculus
J. Biochem.
127
653-658
2000
-
-
-
-
-
-
1
4
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1
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-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347773
Yasohara
Molecular cloning and overexpr ...
Candida magnoliae
Biosci. Biotechnol. Biochem.
64
1430-1436
2000
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-
1
-
-
-
-
-
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2
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-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347774
Forrest
Carbonyl reductase ...
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Chem. Biol. Interact.
129
21-40
2000
-
-
5
-
-
-
-
-
-
-
-
-
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5
-
-
-
-
-
5
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
5
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347766
Imamura
Purification and catalytic pro ...
Oryctolagus cuniculus
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125
41-47
1999
-
-
-
-
-
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2
9
-
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2
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1
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1
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-
1
-
-
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
9
-
-
2
-
-
-
-
1
-
1
-
-
9
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347771
Okamoto
Microsomal carbonyl reductase ...
Rattus norvegicus
IUBMB Life
48
543-547
1999
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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347772
Wada
Purification and characterizat ...
Candida magnoliae
Biosci. Biotechnol. Biochem.
62
280-285
1998
-
-
-
-
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2
10
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3
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3
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1
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-
-
-
-
6
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
2
-
10
-
-
3
-
-
-
-
1
-
-
-
-
6
1
1
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-
-
1
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-
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-
-
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-
347761
Nakanishi
Switch of coenzyme specificity ...
Mus musculus
J. Biol. Chem.
272
2218-2222
1997
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1
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1
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-
-
-
-
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-
1
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-
-
-
-
-
-
-
-
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Cloning and expression of carb ...
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Characterization of multiple f ...
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A novel NADH-dependent carbony ...
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Purification and characterizat ...
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Activation of carbonyl reducta ...
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347763
Inazu
Carbonyl reductase from human ...
Homo sapiens
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Matsuura
Kinetic mechanism of pulmonary ...
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Bohren
Inactivation of carbonyl reduc ...
Homo sapiens
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Bohren
Kinetics of carbonyl reductase ...
Homo sapiens
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Nakayama
Characterization of pulmonary ...
Cavia porcellus, Mus musculus
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Wermuth
Carbonyl reductase provides th ...
Homo sapiens
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Usui
Purification and characterizat ...
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Nakayama
Purification and characterizat ...
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Wermuth
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