BRENDA - Enzyme Database show
show all sequences of 1.1.1.179

Identity of dimeric dihydrodiol dehydrogenase as NADP+-dependent D-xylose dehydrogenase in pig liver

Aoki, S.; Ishikura, S.; Asada, Y.; Usami, N.; Hara, A.; Chem. Biol. Interact. 130-132, 775-784 (2001)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
KCl
increase in activity about 2fold
Sus scrofa
MgCl2
increase in activity about 4fold
Sus scrofa
additional information
-
Macaca fuscata
additional information
higher salt concentration elevates the activity
Sus scrofa
Engineering
Amino acid exchange
Commentary
Organism
H79Q
large increase in Km for coenzyme and substrates
Macaca fuscata
Y180F
-
Macaca fuscata
Inhibitors
Inhibitors
Commentary
Organism
Structure
High salt concentration
recombinant H79Q mutant
Macaca fuscata
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0011
-
NADP+
+ 20 mM MgCl2
Sus scrofa
1.3
-
D-xylose
25 mM Tris + 20 mM MgCl2
Sus scrofa
6.4
-
D-xylose
-
Macaca fuscata
6.5
-
D-xylose
-
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-xylose + NADP+
Homo sapiens
-
D-xylono-1,5-lactone + NADPH + H+
-
Homo sapiens
?
D-xylose + NADP+
Sus scrofa
-
D-xylono-1,5-lactone + NADPH + H+
-
Sus scrofa
?
D-xylose + NADP+
Oryctolagus cuniculus
-
D-xylono-1,5-lactone + NADPH + H+
-
Oryctolagus cuniculus
?
D-xylose + NADP+
Canis lupus familiaris
-
D-xylono-1,5-lactone + NADPH + H+
-
Canis lupus familiaris
?
D-xylose + NADP+
Macaca fuscata
-
D-xylono-1,5-lactone + NADPH + H+
-
Macaca fuscata
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Macaca fuscata
-
-
-
Oryctolagus cuniculus
-
-
-
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
-
Canis lupus familiaris
-
Macaca fuscata
-
Oryctolagus cuniculus
-
Sus scrofa
Reaction
Reaction
Commentary
Organism
D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH + H+
ordered bi-bi mechanism
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
intestine
exclusively
Homo sapiens
-
kidney
exclusively
Macaca fuscata
-
lens
-
Canis lupus familiaris
-
lens
-
Oryctolagus cuniculus
-
lens
-
Sus scrofa
-
liver
-
Canis lupus familiaris
-
liver
-
Sus scrofa
-
additional information
enzyme activity is found in almost all tissues
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.6
-
-
Sus scrofa
9
-
-
Macaca fuscata
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-xylose + NADP+
-
286128
Homo sapiens
D-xylono-1,5-lactone + NADPH + H+
-
286128
Homo sapiens
?
D-xylose + NADP+
-
286128
Sus scrofa
D-xylono-1,5-lactone + NADPH + H+
-
286128
Sus scrofa
?
D-xylose + NADP+
-
286128
Oryctolagus cuniculus
D-xylono-1,5-lactone + NADPH + H+
-
286128
Oryctolagus cuniculus
?
D-xylose + NADP+
-
286128
Canis lupus familiaris
D-xylono-1,5-lactone + NADPH + H+
-
286128
Canis lupus familiaris
?
D-xylose + NADP+
-
286128
Macaca fuscata
D-xylono-1,5-lactone + NADPH + H+
-
286128
Macaca fuscata
?
additional information
-
286128
Sus scrofa
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Homo sapiens
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Oryctolagus cuniculus
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Canis lupus familiaris
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Macaca fuscata
?
-
-
-
-
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Sus scrofa
?
-
-
-
?
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Oryctolagus cuniculus
?
-
-
-
?
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Canis lupus familiaris
?
-
-
-
?
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Macaca fuscata
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Sus scrofa
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Oryctolagus cuniculus
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Canis lupus familiaris
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Macaca fuscata
?
-
-
-
?
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Canis lupus familiaris
7.5
-
assay at
Macaca fuscata
7.5
-
assay at
Oryctolagus cuniculus
7.5
-
assay at
Sus scrofa
10
-
dihydrodiol dehydrogenase activity assay at
Canis lupus familiaris
10
-
dihydrodiol dehydrogenase activity assay at
Macaca fuscata
10
-
dihydrodiol dehydrogenase activity assay at
Oryctolagus cuniculus
10
-
dihydrodiol dehydrogenase activity assay at
Sus scrofa
Cofactor
Cofactor
Commentary
Organism
Structure
additional information
Tyr71, His79, Lys97 involved in coenzyme binding
Macaca fuscata
additional information
-
Sus scrofa
NADP+
-
Canis lupus familiaris
NADP+
-
Homo sapiens
NADP+
Tyr71, His79, Lys97 involved in coenzyme binding
Macaca fuscata
NADP+
-
Oryctolagus cuniculus
NADP+
-
Sus scrofa
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
KCl
increase in activity about 2fold
Sus scrofa
MgCl2
increase in activity about 4fold
Sus scrofa
additional information
-
Macaca fuscata
additional information
higher salt concentration elevates the activity
Sus scrofa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
additional information
Tyr71, His79, Lys97 involved in coenzyme binding
Macaca fuscata
additional information
-
Sus scrofa
NADP+
-
Canis lupus familiaris
NADP+
-
Homo sapiens
NADP+
Tyr71, His79, Lys97 involved in coenzyme binding
Macaca fuscata
NADP+
-
Oryctolagus cuniculus
NADP+
-
Sus scrofa
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
H79Q
large increase in Km for coenzyme and substrates
Macaca fuscata
Y180F
-
Macaca fuscata
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
High salt concentration
recombinant H79Q mutant
Macaca fuscata
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0011
-
NADP+
+ 20 mM MgCl2
Sus scrofa
1.3
-
D-xylose
25 mM Tris + 20 mM MgCl2
Sus scrofa
6.4
-
D-xylose
-
Macaca fuscata
6.5
-
D-xylose
-
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-xylose + NADP+
Homo sapiens
-
D-xylono-1,5-lactone + NADPH + H+
-
Homo sapiens
?
D-xylose + NADP+
Sus scrofa
-
D-xylono-1,5-lactone + NADPH + H+
-
Sus scrofa
?
D-xylose + NADP+
Oryctolagus cuniculus
-
D-xylono-1,5-lactone + NADPH + H+
-
Oryctolagus cuniculus
?
D-xylose + NADP+
Canis lupus familiaris
-
D-xylono-1,5-lactone + NADPH + H+
-
Canis lupus familiaris
?
D-xylose + NADP+
Macaca fuscata
-
D-xylono-1,5-lactone + NADPH + H+
-
Macaca fuscata
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Canis lupus familiaris
-
Macaca fuscata
-
Oryctolagus cuniculus
-
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
intestine
exclusively
Homo sapiens
-
kidney
exclusively
Macaca fuscata
-
lens
-
Canis lupus familiaris
-
lens
-
Oryctolagus cuniculus
-
lens
-
Sus scrofa
-
liver
-
Canis lupus familiaris
-
liver
-
Sus scrofa
-
additional information
enzyme activity is found in almost all tissues
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
7.6
-
-
Sus scrofa
9
-
-
Macaca fuscata
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-xylose + NADP+
-
286128
Homo sapiens
D-xylono-1,5-lactone + NADPH + H+
-
286128
Homo sapiens
?
D-xylose + NADP+
-
286128
Sus scrofa
D-xylono-1,5-lactone + NADPH + H+
-
286128
Sus scrofa
?
D-xylose + NADP+
-
286128
Oryctolagus cuniculus
D-xylono-1,5-lactone + NADPH + H+
-
286128
Oryctolagus cuniculus
?
D-xylose + NADP+
-
286128
Canis lupus familiaris
D-xylono-1,5-lactone + NADPH + H+
-
286128
Canis lupus familiaris
?
D-xylose + NADP+
-
286128
Macaca fuscata
D-xylono-1,5-lactone + NADPH + H+
-
286128
Macaca fuscata
?
additional information
-
286128
Sus scrofa
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Homo sapiens
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Oryctolagus cuniculus
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Canis lupus familiaris
?
-
-
-
-
additional information
catalyzing oxidation of trans-dihydrodiols of aromatic hydrocarbons to corresponding catechols, probably identical with dimeric dihydrodiol dehydrogenase EC 1.3.1.20
286128
Macaca fuscata
?
-
-
-
-
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Sus scrofa
?
-
-
-
?
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Oryctolagus cuniculus
?
-
-
-
?
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Canis lupus familiaris
?
-
-
-
?
trans-benzene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Macaca fuscata
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Sus scrofa
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Oryctolagus cuniculus
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Canis lupus familiaris
?
-
-
-
?
trans-naphthalene dihydrodiol + NADP+
dihydrodiol dehydrogenase activity, probably identical with EC 1.3.1.20
286128
Macaca fuscata
?
-
-
-
?
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
assay at
Canis lupus familiaris
7.5
-
assay at
Macaca fuscata
7.5
-
assay at
Oryctolagus cuniculus
7.5
-
assay at
Sus scrofa
10
-
dihydrodiol dehydrogenase activity assay at
Canis lupus familiaris
10
-
dihydrodiol dehydrogenase activity assay at
Macaca fuscata
10
-
dihydrodiol dehydrogenase activity assay at
Oryctolagus cuniculus
10
-
dihydrodiol dehydrogenase activity assay at
Sus scrofa
Other publictions for EC 1.1.1.179
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
723749
Mihasan
Evidence of a plasmid-encoded ...
Paenarthrobacter nicotinovorans
Res. Microbiol.
164
22-30
2013
-
-
1
-
-
-
-
3
-
1
1
-
-
1
-
-
-
-
-
-
-
-
3
1
-
-
-
3
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
3
-
1
1
-
-
-
-
-
-
-
-
-
3
1
-
-
-
3
-
-
-
-
-
-
-
-
3
3
724150
Ahmed
-
Oxidation and reduction of D-x ...
Ogataea angusta
Aust. J. Basic Appl. Sci.
5
95-100
2011
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725867
Nygard
Bioconversion of d-xylose to d ...
Trichoderma reesei
Metab. Eng.
13
383-391
2011
-
1
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
698940
Johnsen
D-xylose degradation pathway i ...
Haloferax volcanii, Haloferax volcanii DS2, Haloferax volcanii GR501
J. Biol. Chem.
284
27290-27303
2009
1
-
1
-
1
-
-
6
-
-
3
2
-
4
-
-
1
-
-
1
3
-
12
1
-
-
-
-
-
-
-
2
-
-
-
1
-
2
2
-
1
-
-
-
-
6
-
-
3
2
-
-
-
1
-
1
3
-
12
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684150
Carbone
Structure of monkey dimeric di ...
Macaca fascicularis
Acta Crystallogr. Sect. D
64
532-542
2008
-
-
1
1
15
-
2
13
-
-
-
2
-
2
-
-
1
-
-
-
-
-
2
1
-
-
-
8
1
-
-
1
-
-
-
-
-
1
1
1
15
-
-
2
-
13
-
-
-
2
-
-
-
1
-
-
-
-
2
1
-
-
-
8
1
-
-
-
-
-
-
-
-
-
686797
Berghaell
Identification in the mould Hy ...
Trichoderma reesei
FEMS Microbiol. Lett.
277
249-253
2007
-
-
1
-
-
-
-
4
-
1
1
1
-
1
-
-
1
-
-
-
1
-
6
1
1
-
-
2
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
4
-
1
1
1
-
-
-
1
-
-
1
-
6
1
1
-
-
2
1
-
-
-
-
-
-
-
-
-
655884
Johnsen
Novel xylose dehydrogenase in ...
Haloarcula marismortui
J. Bacteriol.
186
6198-6207
2004
-
-
1
-
-
-
-
3
-
3
2
1
-
1
-
-
1
-
-
1
1
-
5
1
2
1
-
3
1
1
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
3
-
3
2
1
-
-
-
1
-
1
1
-
5
1
2
1
-
3
1
1
-
-
-
-
-
-
3
3
286128
Aoki
Identity of dimeric dihydrodio ...
Canis lupus familiaris, Homo sapiens, Macaca fuscata, Oryctolagus cuniculus, Sus scrofa
Chem. Biol. Interact.
130-132
775-784
2001
4
-
-
-
2
-
1
4
-
-
-
5
-
10
-
-
4
1
-
8
2
-
18
-
-
-
-
-
8
-
-
7
-
-
-
4
-
-
7
-
2
-
-
1
-
4
-
-
-
5
-
-
-
4
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