Cloned (Comment) | Organism |
---|---|
gene Nsdhl, located on the X-chromosome, genotyping in 233 mice from a F2 cross between KK/HlJ and I/LnJ | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ | Mus musculus | - |
a 3-oxosteroid + CO2 + NAD(P)H | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9R1J0 | I/LnJ and KK/HlJ inbred strains and cross breeds between KK/HlJ and I/LnJ | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ | - |
Mus musculus | a 3-oxosteroid + CO2 + NAD(P)H | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NSDHL | - |
Mus musculus |
sterol-4-alpha-carboxylate 3-dehydrogenase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | a I/LnJ-specific nonsynonymous polymorphism in X-linked Nsdhl, which codes for sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway, causes reduced HDL cholesterol levels in plasma | Mus musculus |
metabolism | the enzyme sterol-4-alpha-carboxylate 3-dehydrogenase is important in the cholesterol synthesis pathway | Mus musculus |
additional information | HDL and non-HDL lipid contents in different mouse genotypes and correlation to gene Nsdhl, overview | Mus musculus |