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Literature summary for 1.1.1.170 extracted from

  • Bautz, D.J.; Broman, K.W.; Threadgill, D.W.
    Identification of a novel polymorphism in X-linked sterol-4-alpha-carboxylate 3-dehydrogenase (Nsdhl) associated with reduced high-density lipoprotein cholesterol levels in I/LnJ mice (2013), G3 (Bethesda), 3, 1819-1825.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene Nsdhl, located on the X-chromosome, genotyping in 233 mice from a F2 cross between KK/HlJ and I/LnJ Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ Mus musculus
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a 3-oxosteroid + CO2 + NAD(P)H
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9R1J0 I/LnJ and KK/HlJ inbred strains and cross breeds between KK/HlJ and I/LnJ
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+
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Mus musculus a 3-oxosteroid + CO2 + NAD(P)H
-
?

Synonyms

Synonyms Comment Organism
NSDHL
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Mus musculus
sterol-4-alpha-carboxylate 3-dehydrogenase
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Mus musculus

General Information

General Information Comment Organism
malfunction a I/LnJ-specific nonsynonymous polymorphism in X-linked Nsdhl, which codes for sterol-4-alpha-carboxylate 3-dehydrogenase in the cholesterol synthesis pathway, causes reduced HDL cholesterol levels in plasma Mus musculus
metabolism the enzyme sterol-4-alpha-carboxylate 3-dehydrogenase is important in the cholesterol synthesis pathway Mus musculus
additional information HDL and non-HDL lipid contents in different mouse genotypes and correlation to gene Nsdhl, overview Mus musculus