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show all sequences of 1.1.1.170

NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets

Caldas, H.; Herman, G.E.; Hum. Mol. Genet. 12, 2981-91 (2003)

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Homo sapiens
5783
-
lipid droplet
surface of
Homo sapiens
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
-
-
?
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
-
-
?
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
-
Homo sapiens
5783
-
lipid droplet
surface of
Homo sapiens
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
-
-
?
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+
enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
722377
Homo sapiens
5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects
Homo sapiens
Other publictions for EC 1.1.1.170
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
656813
Lucas
Identification of two novel mu ...
Mus musculus
Mol. Genet. Metab.
80
227-233
2003
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722377
Caldas
NSDHL, an enzyme involved in c ...
Homo sapiens
Hum. Mol. Genet.
12
2981-91
2003
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723668
Gachotte
Characterization of the Saccha ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
95
13794-9
1998
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286111
Rahimtula
Investigation of the component ...
Rattus sp.
J. Biol. Chem.
247
9-15
1972
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