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Literature summary for 1.1.1.17 extracted from

  • Sand, M.; Rodrigues, M.; Gonzalez, J.M.; de Crecy-Lagard, V.; Santos, H.; Mueller, V.; Averhoff, B.
    Mannitol-1-phosphate dehydrogenases/phosphatases: a family of novel bifunctional enzymes for bacterial adaptation to osmotic stress (2015), Environ. Microbiol., 17, 711-719.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene mtlD, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis Acinetobacter baylyi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-mannitol 1-phosphate + NADP+ Acinetobacter baylyi
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D-fructose 6-phosphate + NADPH + H+
-
r
D-mannitol 1-phosphate + NADP+ Acinetobacter baylyi ATCC 33305
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D-fructose 6-phosphate + NADPH + H+
-
r
additional information Acinetobacter baylyi MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain ?
-
?
additional information Acinetobacter baylyi ATCC 33305 MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain ?
-
?

Organism

Organism UniProt Comment Textmining
Acinetobacter baylyi Q6FBP5
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-
Acinetobacter baylyi ATCC 33305 Q6FBP5
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-mannitol 1-phosphate + NADP+
-
Acinetobacter baylyi D-fructose 6-phosphate + NADPH + H+
-
r
D-mannitol 1-phosphate + NADP+
-
Acinetobacter baylyi ATCC 33305 D-fructose 6-phosphate + NADPH + H+
-
r
additional information MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain Acinetobacter baylyi ?
-
?
additional information MtlD is a bifunctional enzyme of mannitol biosynthesis that combines mannitol-1-phosphate dehydrogenase and phosphatase activities in a single polypeptide chain Acinetobacter baylyi ATCC 33305 ?
-
?

Synonyms

Synonyms Comment Organism
mannitol-1-phosphate dehydrogenase
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Acinetobacter baylyi
Mtl-1-P dehydrogenase
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Acinetobacter baylyi
MtlD
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Acinetobacter baylyi

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Acinetobacter baylyi
NADPH
-
Acinetobacter baylyi

General Information

General Information Comment Organism
evolution the C-terminus of MtlD from Acinetobacter baylyi is similar to dehydrogenase domains found in other dehydrogenases with a glycine-rich conserved domain (Rossmann-fold) starting at position 247 for cosubstrate binding (GIHGFGAIGGG). The N-terminal domain of MtlD is similar to members of the HAD (haloacid dehalogenase) superfamily Acinetobacter baylyi
metabolism mannitol-1-phosphate dehydrogenase MtlD is essential for mannitol biosynthesis and catalyses the first step in mannitol biosynthesis, the reduction of fructose-6-phosphate to the intermediate mannitol-1-phosphate Acinetobacter baylyi
physiological function the nutritionally versatile soil bacterium Acinetobacter baylyi ADP1 copes with salt stress by the accumulation of compatible solutes. The bacterium synthesizes the sugar alcohol mannitol de novo in response to osmotic stress. THe enzyme is essential for mannitol 1-phosphate biosynthesis, and it also possesses a unique sequence among known mannitol-1-phosphate dehydrogenases with a haloacid dehalogenase (HAD)-like phosphatase domain at the N-terminus. This domain has phosphatase activity Acinetobacter baylyi