chenodeoxycholic acid + NAD+
656301
Pseudomonas sp.
3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
chenodeoxycholic acid + NAD+
656301
Pseudomonas sp. B-0831
3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
cholic acid + NAD+
656301
Pseudomonas sp.
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
cholic acid + NAD+
656301
Pseudomonas sp. B-0831
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
additional information
catalyzes the oxido-reduction of 7alpha-hydroxy bile acids including glycine and taurine conjugates
656301
Pseudomonas sp.
?
additional information
catalyzes the oxido-reduction of 7alpha-hydroxy bile acids including glycine and taurine conjugates
656301
Pseudomonas sp. B-0831
?
chenodeoxycholic acid + NAD+
656301
Pseudomonas sp.
3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
chenodeoxycholic acid + NAD+
656301
Pseudomonas sp. B-0831
3alpha-hydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
cholic acid + NAD+
656301
Pseudomonas sp.
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
cholic acid + NAD+
656301
Pseudomonas sp. B-0831
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholan-24-oic acid + NADH
?
additional information
catalyzes the oxido-reduction of 7alpha-hydroxy bile acids including glycine and taurine conjugates
656301
Pseudomonas sp.
?
additional information
catalyzes the oxido-reduction of 7alpha-hydroxy bile acids including glycine and taurine conjugates
656301
Pseudomonas sp. B-0831
?
740787
Eggert
Enzymatic routes for the synth ...
Acinetobacter calcoaceticus, Bacteroides fragilis, Clostridium sardiniense, Escherichia coli, Pseudomonas sp., Stenotrophomonas maltophilia
J. Biotechnol.
191
11-21
2014
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4
1
1
6
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3
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5
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6
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1
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4
-
12
1
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1
3
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7
-
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4
1
7
1
6
-
-
-
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3
-
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5
-
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1
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-
4
-
12
1
-
-
1
3
-
-
-
-
-
3
3
-
3
3
740971
Ji
Cloning, expression and charac ...
Comamonas testosteroni, Comamonas testosteroni ATCC 11996
Microbiol. Res.
169
148-154
2014
-
-
1
-
1
-
-
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2
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3
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1
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1
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2
1
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1
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1
1
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1
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-
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-
-
-
-
-
2
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
3
3
-
-
-
741371
Lou
Carboxyl-terminal and Arg38 ar ...
Clostridium sardiniense
Protein Pept. Lett.
21
894-900
2014
-
-
1
-
2
-
-
-
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3
-
1
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3
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-
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1
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1
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1
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1
1
-
2
-
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-
-
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3
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
3
3
-
-
-
697994
Fukiya
Conversion of cholic acid and ...
Bacteroides fragilis, Bacteroides fragilis NCTC 9343, Bacteroides intestinalis, Bacteroides intestinalis am-1, Escherichia coli HB101
FEMS Microbiol. Lett.
293
263-270
2009
6
-
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-
-
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-
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13
-
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-
-
-
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10
-
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6
-
-
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-
-
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-
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-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701240
Giovannini
7alpha- and 12alpha-Hydroxyste ...
Acinetobacter lwoffii
Steroids
73
1385-1390
2008
1
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670898
Pedrini
Xanthomonas maltophilia CBS 89 ...
Stenotrophomonas maltophilia, Stenotrophomonas maltophilia CBS 897.97
Steroids
71
189-198
2006
-
1
-
-
-
-
-
2
-
-
-
1
-
3
-
-
1
-
-
-
2
1
7
-
1
-
-
-
1
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
2
-
-
-
1
-
-
-
1
-
-
2
1
7
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670926
Zhu
-
Enzymatic enantioselective red ...
Bacteroides fragilis
Tetrahedron
62
4535-4539
2006
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
-
16
-
1
-
1
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
16
-
1
-
1
-
1
-
-
-
-
-
-
-
-
-
656301
Ueda
-
Molecular and enzymatic proper ...
Pseudomonas sp., Pseudomonas sp. B-0831
J. Biol. Macromol.
4
33-38
2004
-
-
-
-
-
-
-
1
-
-
2
-
-
6
-
-
1
-
-
-
-
-
6
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
2
-
-
-
-
1
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655302
Bennett
Cloning and characterization o ...
Bacteroides fragilis, Clostridium scindens, Escherichia coli, Paeniclostridium sordellii
Curr. Microbiol.
47
475-484
2003
-
-
1
-
-
-
2
4
-
-
2
-
-
6
-
-
1
-
-
-
1
-
8
1
-
-
4
-
2
1
-
5
-
-
-
-
-
1
5
-
-
-
-
2
-
4
-
-
2
-
-
-
-
1
-
-
1
-
8
1
-
-
4
-
2
1
-
-
-
-
-
-
-
-
286083
Tanabe
Roles of the Ser146, Tyr159, a ...
Escherichia coli
J. Biochem.
124
634-641
1998
-
-
1
1
6
-
-
12
-
-
2
-
-
2
-
-
1
1
-
-
-
-
-
1
-
-
-
6
1
1
-
1
-
-
-
-
-
1
1
1
6
-
-
-
-
12
-
-
2
-
-
-
-
1
-
-
-
-
-
1
-
-
-
6
1
1
-
-
-
-
-
-
-
-
286081
Tanaka
Crystal structures of the bina ...
Escherichia coli
Biochemistry
35
7715-7730
1996
-
-
-
1
-
-
-
-
-
-
-
1
-
2
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286084
Coleman
Characterization and regulatio ...
Paeniclostridium sordellii
J. Bacteriol.
176
4865-4874
1994
-
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
1
1
-
-
1
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286082
Baron
Cloning, sequencing, and expre ...
Eubacterium sp., Eubacterium sp. VPI 12708
J. Bacteriol.
173
4558-4569
1991
-
-
1
-
-
-
-
-
-
-
1
4
-
12
-
-
1
-
-
-
2
-
8
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
1
4
-
-
-
1
-
-
2
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286085
Yoshimoto
Cloning and sequencing of the ...
Escherichia coli
J. Bacteriol.
173
2173-2179
1991
-
-
1
1
-
-
12
5
-
-
2
-
-
3
-
-
1
-
-
-
-
-
6
1
-
-
-
5
1
-
1
1
-
-
-
-
-
1
1
1
-
-
-
12
-
5
-
-
2
-
-
-
-
1
-
-
-
-
6
1
-
-
-
5
1
-
1
-
-
-
-
-
-
-
286072
Prabha
Purification of 7alpha-hydroxy ...
Escherichia coli
Can. J. Microbiol.
36
131-135
1990
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
-
1
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
286073
Prabha
Kinetic properties of 7alpha-h ...
Escherichia coli
Can. J. Microbiol.
35
1076-1080
1989
2
-
-
-
-
-
18
-
-
4
-
-
-
1
-
-
-
-
-
-
8
-
6
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
18
-
-
-
4
-
-
-
-
-
-
-
-
8
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286074
Ottolina
Enzymatic synthesis of [4R-2H] ...
Escherichia coli
Biochim. Biophys. Acta
998
173-178
1989
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286075
Kinoshita
-
Purification and properties of ...
Brevibacterium fuscum
J. Ferment. Technol.
66
145-152
1988
-
-
-
-
-
-
-
8
-
-
2
-
-
1
-
-
1
-
-
-
4
-
8
1
1
1
2
-
3
-
2
1
-
-
-
-
-
-
1
-
-
-
-
-
-
8
-
-
2
-
-
-
-
1
-
-
4
-
8
1
1
1
2
-
3
-
2
-
-
-
-
-
-
-
286076
MacDonald
Bile induction of 7alpha- and ...
Clostridium sardiniense
Biochim. Biophys. Acta
665
262-269
1981
-
-
-
-
-
-
-
3
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
286077
Haslewood
The specificity of a 7alpha-hy ...
Escherichia coli
Biochem. J.
157
207-210
1976
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
286078
Hylemon
Multiple forms of 7-alpha-hydr ...
Bacteroides fragilis
J. Bacteriol.
122
418-424
1975
-
-
-
-
-
-
2
-
-
2
2
1
-
1
-
-
1
-
-
-
-
-
7
-
-
-
2
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
2
2
1
-
-
-
1
-
-
-
-
7
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
286079
MacDonald
NAD- and NADP-dependent 7alpha ...
Bacteroides fragilis
Biochim. Biophys. Acta
384
12-24
1975
-
-
-
-
-
1
-
7
-
-
-
-
-
3
-
-
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
2
-
-
1
-
-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
286080
MacDonald
7alpha-hydroxysteroid dehydrog ...
Escherichia coli
Biochim. Biophys. Acta
309
243-253
1973
-
-
-
-
-
2
3
6
-
-
-
1
-
2
-
-
-
-
-
-
-
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7
-
-
-
-
-
1
-
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1
-
-
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-
1
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-
2
-
3
-
6
-
-
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1
-
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-
-
-
-
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7
-
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-
-
1
-
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-
-
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-
-
-