BRENDA - Reference to 1.1.1.153; Id = 667828

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum

-

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum AX2

-

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum

-

L-erythro-tetrahydrobiopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum AX2

-

L-erythro-tetrahydrobiopterin + NADP+

-

?

6-pyruvoyltetrahydropterin + NADPH

Dictyostelium discoideum

-

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

no synthesis of the D-isomer

-

?

additional information

Dictyostelium discoideum

quantitative in vivo assay and product determination

?

-

additional information

Dictyostelium discoideum AX2

quantitative in vivo assay and product determination

?

-

Dictyostelium discoideum

-

strain AX2

-

Dictyostelium discoideum AX2

-

strain AX2

-

additional information

SR gene expression and activity in different developmental stages

Dictyostelium discoideum

-

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

preferred substrate

667828

Dictyostelium discoideum

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum AX2

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

preferred substrate

667828

Dictyostelium discoideum AX2

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum

L-erythro-tetrahydrobiopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum AX2

L-erythro-tetrahydrobiopterin + NADP+

-

?

6-pyruvoyltetrahydropterin + NADPH

-

667828

Dictyostelium discoideum

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

no synthesis of the D-isomer

-

?

additional information

product determination

667828

Dictyostelium discoideum

?

-

additional information

quantitative in vivo assay and product determination

667828

Dictyostelium discoideum

?

-

additional information

product determination

667828

Dictyostelium discoideum AX2

?

-

additional information

quantitative in vivo assay and product determination

667828

Dictyostelium discoideum AX2

?

-

22

-

assay at

Dictyostelium discoideum

6.5

-

assay at

Dictyostelium discoideum

NADPH

-

Dictyostelium discoideum

NADPH

-

Dictyostelium discoideum

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum

-

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum AX2

-

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum

-

L-erythro-tetrahydrobiopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

Dictyostelium discoideum AX2

-

L-erythro-tetrahydrobiopterin + NADP+

-

?

6-pyruvoyltetrahydropterin + NADPH

Dictyostelium discoideum

-

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

no synthesis of the D-isomer

-

?

additional information

Dictyostelium discoideum

quantitative in vivo assay and product determination

?

-

additional information

Dictyostelium discoideum AX2

quantitative in vivo assay and product determination

?

-

additional information

SR gene expression and activity in different developmental stages

Dictyostelium discoideum

-

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

preferred substrate

667828

Dictyostelium discoideum

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum AX2

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH

preferred substrate

667828

Dictyostelium discoideum AX2

tetrahydrodictyopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum

L-erythro-tetrahydrobiopterin + NADP+

-

?

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH

-

667828

Dictyostelium discoideum AX2

L-erythro-tetrahydrobiopterin + NADP+

-

?

6-pyruvoyltetrahydropterin + NADPH

-

667828

Dictyostelium discoideum

1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+

no synthesis of the D-isomer

-

?

additional information

product determination

667828

Dictyostelium discoideum

?

-

additional information

quantitative in vivo assay and product determination

667828

Dictyostelium discoideum

?

-

additional information

product determination

667828

Dictyostelium discoideum AX2

?

-

additional information

quantitative in vivo assay and product determination

667828

Dictyostelium discoideum AX2

?

-

22

-

assay at

Dictyostelium discoideum

6.5

-

assay at

Dictyostelium discoideum

739887

Tang

Expression and enzyme activity ...

Musca domestica

Appl. Biochem. Biotechnol.

181

604-612

2016

-

1

-

1

-

3

-

1

-

8

-

1

-

1

-

1

-

1

-

1

-

1

-

8

-

1

-

1

-

1

2

1

-

740231

Yco

Effect of sulfasalazine on hum ...

Homo sapiens

BMC Cancer

15

477

2015

-

1

-

1

-

4

-

2

-

2

-

4

-

3

1

-

1

-

1

-

1

-

4

-

2

-

4

-

3

1

-

1

3

1

-

740892

Yang

Sulfa drugs inhibit sepiapteri ...

Homo sapiens, Rattus norvegicus

J. Pharmacol. Exp. Ther.

352

529-540

2015

-

16

-

2

-

3

-

2

-

4

-

2

-

5

-

2

-

14

-

2

-

14

16

-

2

-

2

-

4

-

2

-

5

-

3

-

741390

Kim

-

Functional analysis of sepiapt ...

Drosophila melanogaster

Pteridines

26

63-68

2015

-

1

-

3

-

728158

Lange

Novel interaction of ornithine ...

Homo sapiens

J. Mol. Biol.

426

332-346

2014

-

1

-

1

-

2

-

2

-

2

-

2

-

1

-

1

-

1

-

2

-

2

-

2

-

2

-

725527

Yang

Sepiapterin Reductase Mediates ...

Homo sapiens

J. Biol. Chem.

288

19221-19237

2013

-

1

-

10

-

7

21

-

1

-

3

-

1

-

6

-

1

-

24

1

-

4

-

7

-

1

-

10

-

7

4

21

-

1

-

1

-

6

-

1

-

24

1

-

695487

Gao

Sepiapterin reductase regulati ...

Bos taurus

Am. J. Physiol. Heart Circ. Physiol.

297

H331-H339

2009

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

698671

Hirakawa

Expression analysis of the ald ...

Homo sapiens, Mus musculus

J. Biochem.

146

51-60

2009

-

2

-

5

-

2

-

4

-

2

-

2

-

2

-

2

-

4

-

698883

Meng

The silkworm mutant lemon (lem ...

Bombyx mori

J. Biol. Chem.

284

11698-11705

2009

-

1

-

2

1

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

700603

McHugh

Polymorphisms of sepiapterin r ...

Homo sapiens

Pharmacogenet. Genomics

19

330-337

2009

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

684899

Takazawa

A brain-specific decrease of t ...

Mus musculus

Biochem. Biophys. Res. Commun.

367

787-792

2008

-

1

-

2

-

4

-

1

-

2

-

1

-

2

-

1

-

2

-

689027

Sawabe

Cellular uptake of sepiapterin ...

Homo sapiens

Mol. Genet. Metab.

94

410-416

2008

-

1

-

1

-

3

-

1

-

1

-

4

-

1

-

1

-

3

-

1

-

4

-

695294

Supangat

Role of Phe-99 and Trp-196 of ...

Chlorobaculum tepidum

Acta Biochim. Biophys. Sin. (Shanghai)

40

513-518

2008

-

1

-

2

-

3

-

3

-

1

-

2

-

1

-

1

-

1

-

2

-

3

-

1

-

2

-

1

-

685875

Tobin

Sepiapterin reductase expressi ...

Homo sapiens

Brain Res.

1139

42-47

2007

-

1

-

1

-

3

-

2

-

2

-

4

-

1

-

1

-

3

-

2

-

4

-

686117

Widder

Regulation of tetrahydrobiopte ...

Homo sapiens

Circ. Res.

101

830-838

2007

1

-

1

-

3

-

2

-

1

-

3

-

2

-

1

-

2

-

1

-

3

-

1

-

3

-

686747

Kim

Tetrahydropteridine deficiency ...

Dictyostelium discoideum

FEBS Lett.

581

5430-5434

2007

-

1

-

3

-

3

-

4

-

1

-

3

-

4

-

667828

Choi

Functional role of sepiapterin ...

Dictyostelium discoideum, Dictyostelium discoideum AX2

Biochim. Biophys. Acta

1760

877-882

2006

-

7

-

11

-

1

-

11

-

1

-

1

-

1

-

1

-

7

-

1

-

11

-

1

-

1

-

668883

Thoeny

Mutations in the BH4-metaboliz ...

Homo sapiens

Hum. Mutat.

27

870-878

2006

-

1

-

6

-

1

-

2

-

1

-

1

-

6

-

1

-

1

-

669482

Supangat

Structure of Chlorobium tepidu ...

Chlorobaculum tepidum

J. Biol. Chem.

281

2249-2256

2006

-

1

-

1

-

5

-

1

-

2

1

-

1

-

1

-

1

-

2

1

-

655640

Choi

Sepiapterin reductases from Ch ...

Chlorobaculum tepidum, Chlorobium limicola

FEMS Microbiol. Lett.

242

95-99

2005

-

2

-

2

-

6

-

2

-

6

-

2

-

2

-

2

-

2

-

6

-

667067

Supangat

Expression, purification, crys ...

Chlorobaculum tepidum

Acta Crystallogr. Sect. F

61

202-204

2005

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

1

-

2

-

668611

Choi

D-threo-tetrahydrobiopterin is ...

Dictyostelium discoideum, Dictyostelium discoideum AX2

FEBS Lett.

579

3085-3089

2005

-

1

-

7

-

10

-

12

-

2

-

2

-

1

-

7

-

12

-

655225

Fujimoto

Effect of antisense oligodeoxy ...

Rattus norvegicus

Chem. Biol. Interact.

143-144

583-586

2003

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

656958

Negishi

Localization of sepiapterin re ...

Oryzias latipes, Rattus norvegicus

Pigment Cell Res.

16

501-503

2003

-

1

-

2

-

8

-

1

-

2

-

2

-

2

-

1

-

2

-

1

-

2

-

655138

Ikemoto

Localization of sepiapterin re ...

Homo sapiens, Mus musculus

Brain Res.

954

237-246

2002

-

1

-

2

-

4

-

1

-

13

-

4

-

2

-

1

2

-

2

-

1

-

13

-

4

-

286028

Fujimoto

Role of the conserved Ser-Tyr- ...

Rattus norvegicus

Chem. Biol. Interact.

130-132

825-832

2001

-

1

-

4

-

1

-

1

-

7

-

1

-

4

-

1

-

7

-

286030

Kim

Characterization of recombinan ...

Dictyostelium discoideum, Phycomyces sp.

Mol. Cells

10

405-410

2000

-

1

-

2

-

3

1

-

5

-

1

-

1

-

1

-

2

-

2

-

3

1

-

1

-

1

-

286026

Cho

-

Sepiapterin reductase producin ...

Chlorobaculum tepidum

Biochem. J.

340

497-503

1999

-

3

-

2

1

-

1

-

1

-

1

8

1

-

1

-

1

-

1

-

1

-

3

-

3

-

2

1

-

1

-

1

8

1

-

1

-

1

-

286032

Auerbach

The 1.25 A crystal structure o ...

Mus musculus

EMBO J.

16

7219-7230

1997

-

1

-

4

-

1

-

2

-

1

-

1

-

1

-

1

-

4

-

1

-

1

-

1

-

286029

Ruiz-Vazquez

Characterization of sepiapteri ...

Drosophila melanogaster, Drosophila melanogaster Oregon R

Comp. Biochem. Physiol. B

113

131-136

1996

-

3

1

-

2

-

7

-

1

-

2

-

1

-

3

-

1

-

2

-

1

-

2

-

1

-

286025

Maier

Purification and properties of ...

Homo sapiens

Adv. Exp. Med. Biol.

338

199-202

1993

-

2

-

3

1

-

2

-

1

-

2

1

-

1

-

2

-

3

1

-

1

-

2

1

-

1

-

286031

Yoon

-

Isolation and characterization ...

Drosophila melanogaster, Drosophila melanogaster Oregon R

Pteridines

4

43-50

1993

-

6

2

-

2

-

5

-

1

-

1

12

1

-

1

-

1

-

6

-

2

-

2

-

1

-

1

12

1

-

1

-

1

-

286033

Dowling

Sepiapterin reductase and ALR2 ...

Bos taurus

Adv. Exp. Med. Biol.

328

313-324

1993

-

2

1

-

2

-

1

-

2

1

-

2

1

-

1

-

2

1

-

286027

Smith

New inhibitors of sepiapterin ...

Bos taurus

J. Biol. Chem.

267

5599-5607

1992

-

11

-

1

-

1

-

3

-

1

-

2

-

1

-

11

-

1

-

1

-

1

-

2

-

1

-

286010

Citron

Isolation and expression of ra ...

Rattus norvegicus

Proc. Natl. Acad. Sci. USA

87

6436-6440

1990

-

1

-

1

-

3

-

1

-

2

1

-

2

-

1

-

1

-

1

-

1

-

2

1

-

2

-

286017

Werner

Tetrahydrobiopterin biosynthet ...

Drosophila melanogaster, Drosophila melanogaster Oregon R, Homo sapiens

J. Biol. Chem.

265

3189-3192

1990

-

3

-

7

-

1

-

6

-

4

-

1

-

1

-

3

-

1

-

6

-

4

-

286018

Kerler

Analysis of the tetrahydrobiop ...

Mus musculus

J. Cell. Physiol.

142

268-271

1990

-

1

-

3

-

4

-

1

2

-

1

-

1

-

1

-

4

-

1

2

-

286016

Fere

Sepiapterin reductase in cultu ...

Homo sapiens

Biochem. Biophys. Res. Commun.

148

1475-1481

1987

-

1

2

-

1

-

2

-

6

-

2

-

1

-

1

-

1

-

2

-

1

-

6

-

2

-

286019

Katoh

Isomerization of 6-lactoyl tet ...

Rattus norvegicus

J. Biochem.

101

275-278

1987

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

286024

Smith

On the role of sepiapterin red ...

Rattus norvegicus

Arch. Biochem. Biophys.

255

254-266

1987

-

2

5

-

2

-

3

-

1

-

12

-

11

2

1

-

1

-

1

-

1

-

2

-

5

-

2

-

1

-

12

-

11

2

1

-

1

-

286021

Sueoka

Carbonyl reductase activity of ...

Rattus norvegicus

Biochim. Biophys. Acta

843

193-198

1985

-

13

14

-

1

-

2

-

1

-

2

-

16

-

2

-

13

-

2

-

13

-

14

-

1

-

1

-

2

-

16

-

286022

Curtius

Tetrahydrobiopterin biosynthes ...

Homo sapiens

Eur. J. Biochem.

148

413-419

1985

-

1

-

3

-

1

-

5

-

2

-

1

-

1

-

1

-

1

-

5

-

2

-

286020

Katoh

Sepiapterin reductase exhibits ...

Rattus norvegicus

Biochem. Biophys. Res. Commun.

118

859-866

1984

-

4

-

2

-

1

-

1

-

3

1

-

14

-

2

-

2

-

1

-

1

-

4

-

2

-

1

-

3

1

-

14

-

2

-

2

-

286015

Sueoka

Purification and characterizat ...

Rattus norvegicus

Biochim. Biophys. Acta

717

265-271

1982

-

5

2

-

2

-

2

-

1

-

2

1

2

1

-

1

-

1

-

1

-

1

-

1

5

-

2

-

2

-

1

-

2

1

2

1

-

1

-

286023

Katoh

Direct inhibition of brain sep ...

Rattus norvegicus, Rattus norvegicus Sprague-Dawley

Biochem. Biophys. Res. Commun.

105

75-81

1982

-

9

-

6

-

161

-

1

-

2

-

8

-

1

-

1

-

1

8

-

1

-

9

8

-

6

-

1

-

2

-

8

-

1

-

1

-

286014

Katoh

Sepiapterin reductase in blood ...

Canis lupus familiaris, Cavia porcellus, Gallus gallus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Donryu, Rattus norvegicus Sprague-Dawley, Sus scrofa

Biochim. Biophys. Acta

370

378-388

1974

-

9

-

176

-

25

-

9

-

7

-

7

-

9

-

25

-

9

-

286013

Katoh

Sepiapterin reductase from hor ...

Equus caballus, Rattus norvegicus

Arch. Biochem. Biophys.

146

202-214

1971

-

2

55

9

2

-

5

-

3

-

1

-

13

1

2

19

-

2

-

6

-

2

7

-

6

-

7

-

2

6

55

-

9

2

-

5

-

1

-

13

1

2

19

-

2

-

6

-

2

-

286011

Nagai

Studies on sepiapterin reducta ...

Rattus norvegicus

Arch. Biochem. Biophys.

126

426-435

1968

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

667296

Nagai

-

Studies on sepiapterin reducta ...

Rattus norvegicus

Arch. Biochem. Biophys.

126

420-435

1968

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

286012

Matsubara

Sepiapterin reductase ...

Rattus norvegicus

Biochim. Biophys. Acta

122

202-212

1966

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

2

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2

Data extracted from this reference: