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show all sequences of 1.1.1.150

RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism

Keller, B.; Adamski, J.; J. Steroid Biochem. Mol. Biol. 104, 190-194 (2007)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in HeLa cell and 293T cell
Homo sapiens
expression in HeLa cell and 293T cell
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
isoform RDH12
Homo sapiens
5783
-
endoplasmic reticulum
-
Mus musculus
5783
-
mitochondrion
isoform RDH13
Homo sapiens
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
retinol dehydrogenase isoforms RDH12 and RDH13
-
Mus musculus
-
retinol dehydrogenase isoform RDH12
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dihydrotestosterone + NADH
substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13
688677
Homo sapiens
androstanediol + NAD+
-
-
-
?
additional information
contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12
688677
Mus musculus
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in HeLa cell and 293T cell
Homo sapiens
expression in HeLa cell and 293T cell
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum
isoform RDH12
Homo sapiens
5783
-
endoplasmic reticulum
-
Mus musculus
5783
-
mitochondrion
isoform RDH13
Homo sapiens
5739
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dihydrotestosterone + NADH
substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13
688677
Homo sapiens
androstanediol + NAD+
-
-
-
?
additional information
contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12
688677
Mus musculus
?
-
-
-
-
Other publictions for EC 1.1.1.150
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
688677
Keller
RDH12, a retinol dehydrogenase ...
Homo sapiens, Mus musculus
J. Steroid Biochem. Mol. Biol.
104
190-194
2007
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286007
Holland
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Stereochemistry of hydrogen lo ...
Bos taurus, Eggerthella lenta
Can. J. Chem.
67
1590-1595
1989
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286005
Orr
The stereospecificity of the e ...
Ovis aries aries
J. Biol. Chem.
250
7547-7553
1975
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286006
Orr
The stereochemistry of enzymat ...
Ovis aries aries
J. Steroid Biochem.
6
297-299
1975
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286004
Monder
The 21-hydroxysteroid dehydrog ...
Ovis aries aries
J. Biol. Chem.
240
71-77
1965
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5
8
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6
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5
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