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Literature summary for 1.1.1.150 extracted from

  • Keller, B.; Adamski, J.
    RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism (2007), J. Steroid Biochem. Mol. Biol., 104, 190-194.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cell and 293T cell Mus musculus
expression in HeLa cell and 293T cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
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endoplasmic reticulum isoform RDH12 Homo sapiens 5783
-
mitochondrion isoform RDH13 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 retinol dehydrogenase isoforms RDH12 and RDH13
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Mus musculus
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 retinol dehydrogenase isoform RDH12
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrotestosterone + NADH substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13 Homo sapiens androstanediol + NAD+
-
 ?
additional information contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12 Mus musculus ?
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 ?