Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ag+ | complete inhibition of NAD dehydrogenase II at 0.018 mM | Ovis aries aries | |
Hg2+ | 40% inhibition of NAD dehydrogenase II at 0.004 mM | Ovis aries aries | |
NAD+ | NAD dehydrogenase II, competitive inhibition | Ovis aries aries | |
NADP+ | NAD dehydrogenase II, competitive inhibition | Ovis aries aries | |
p-mercuribenzoate | 79% inhibition of NAD dehydrogenase II at 0.014 mM | Ovis aries aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
NADH | NAD dehydrogenase I | Ovis aries aries | |
0.048 | - |
NADH | NAD dehydrogenase II | Ovis aries aries | |
0.105 | - |
11beta-hydroxy-pregn-4-ene-3,20,21-trione | NAD dehydrogenase II | Ovis aries aries | |
0.111 | - |
17-hydroxy-pregn-4-ene-3,20,21-trione | NAD dehydrogenase II | Ovis aries aries | |
0.172 | - |
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione | NAD dehydrogenase II | Ovis aries aries | |
0.174 | - |
pregn-4-ene-3,20,21-trione | NAD dehydrogenase II | Ovis aries aries | |
0.182 | - |
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione | - |
Ovis aries aries | |
0.221 | - |
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone | - |
Ovis aries aries |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries aries | - |
sheep | - |
Purification (Comment) | Organism |
---|---|
to homogeneity, gel filtration, starch block electrophoresis | Ovis aries aries |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | 2 isoenzymes: NAD dehydrogenase I and II | Ovis aries aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,17-dihydroxy-pregn-4,11-diene-3,20,21-trione + NADH | i.e. 21-dehydro-delta1-cortisol, only NAD dehydrogenase II | Ovis aries aries | 11beta,17,21-trihydroxy-pregn-4,11-diene-3,20-dione + NAD+ | i.e. 21-hydroxy-delta1-cortisol | ? | |
11beta,17-dihydroxy-pregn-4-ene-3,20,21-trione + NADH | - |
Ovis aries aries | 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. cortisol | ? | |
11beta-hydroxy-pregn-4-ene-3,20,21-trione + NADH | i.e. 21-dehydrocorticosterone, only NAD dehydrogenase II | Ovis aries aries | 11beta,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. 21-hydroxycorticosterone | ? | |
17-hydroxy-pregn-4-ene-3,11,20,21-tetraone + NADH | i.e. 21-dehydrocortisone | Ovis aries aries | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NAD+ | i.e. cortisone | ? | |
17-hydroxy-pregn-4-ene-3,20,21-trione + NADH | i.e. 21-dehydro-11-deoxycortisol, only NAD dehydrogenase II | Ovis aries aries | 17,21-dihydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. 21-hydroxy-11-deoxycortisol | ? | |
pregn-4-ene-3,20,21-trione + NADH | i.e. 21-dehydro-11-deoxycorticosterone, only NAD dehydrogenase II | Ovis aries aries | 21-hydroxy-pregn-4-ene-3,20-dione + NAD+ | i.e. 21-hydroxy-11-deoxycorticosterone | ? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
56 | - |
30% loss of activity in 5 min, NAD dehydrogenase I more heat resistant than NAD dehydrogenase II | Ovis aries aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
NAD dehydrogenase II | Ovis aries aries |
6.9 | - |
NAD dehydrogenase I | Ovis aries aries |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Ovis aries aries |